London: Smoker’s Face a condition where smokers look older than they are, is just one of many negative effects caused by heavy tobacco usage, researchers have warned.

“We searched across thousands of traits to identify those that may be affected by how heavily someone smokes. As well as identifying several known adverse effects such as on lung health, we also identified an adverse effect of heavier smoking on facial aging,” said study author Louise Millard from the University of Bristol in UK.

According to the study, published in the journal PLOS Genetics, some people carry one or two copies of a genetic variant that is associated with heavier tobacco use.

To simultaneously identify these two types of effects, the researchers used a novel combination of two data analysis approaches and applied them using data from people in the UK Biobank.

They separated people into two groups. The first contained people who had never smoked, and the second included current and former smokers.

The analysis searched across 18,000 traits and apart from the new finding of more rapid facial aging, also identified several previously reported effects of smoking, confirming the method’s effectiveness.

The known effects of smoking that the analysis identified included worse lung function, and higher risk of chronic obstructive pulmonary disease (COPD) and skin cancer.

Besides emphasising smoking’s many dangers, the study also serves as proof of principle that these data analysis tools can be used to identify effects of other exposures of interest, such as alcohol intake.

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Rajkot, Jan 17: Shikhar Dhawan missed a well-deserved ton by a whisker but laid a solid platform for the aggressive duo of skipper Virat Kohli and KL Rahul to ensure a commanding total of 340 for 6 against Australia in the second ODI here on Friday.

Back in form since the last T20 encounter against Sri Lanka, the senior opener looked solid in his 90-ball-96 while Kohli, back at his familiar one drop position, held the middle-order with a 78 off 76 balls and Rahul (80 off 52 balls) provided the final flourish in what was much improved batting performance from the hosts.

While Dhawan added 81 for the opening stand with Rohit Sharma (42) who would regret this missed opportunity on a batting belter after getting set, the southpaw also had a vital 103-run stand with Kohli for the second wicket.

The Kohli-Rahul duo's 78-run partnership off 10.3 overs was also pivotal as it helped the latter to launch a final assault during the end overs.

While Dhawan's innings had 13 fours and a six, Kohli had six hits to the fence including a classic jab-flick off Pat Cummins (0/53 in 10 overs). Rahul's was a stand-out innings with six boundaries and three -maximums, one of which was a lofted cover drive off Mitchell Starc (0/78 in 10 overs), who had a forgettable day.

Adam Zampa (3/50 in 10 overs) was once again the stand-out performer taking Kohli out of equation for the seventh time in limited overs just when he was looking to get his 44th ODI ton.

At the start, Dhawan began with a bowler's bck-drive, giving a glimpse of what was in store. The southpaw completed his sixth fifty versus Australia in 60 balls as he played shots all around the ground.

The last time Dhawan scored successive fifties was in January 2019 against New Zealand. This was his 29th in 50-over cricket.

The left-hander was particularly harsh on left-arm spinner Ashton Agar (0-63 in 8 overs), whom he hammered for two successive fours in the 25th, a sweep and a reverse-sweep, and then in 27th over stuck a four and a six, not allowing him to settle down.

In fact the 77 runs from 10 overs bowled by fifth and sixth bowling option Marnus Labuschagne (0/14 in 2 overs) was the difference from the last game.

However, Dhawan missed out on his 18th ODI hundred by four runs when he pulled a Kane Richardson ball straight to fine leg in 29th over.

Shreyas Iyer (7) fell cheaply. But Kohli was in sublime touch as he ran the singles and doubles with intensity and also it the loose balls for boundary.