New Delhi: The Union health ministry on Friday revised the dosage of anti-viral drug remdesivir to be administered to coronavirus patients in the moderate stage of illness from the earlier six days to five days as it issued an updated 'Clinical Management Protocols for COVID-19'.

The drug, administered in the form of injection, should be given at a dose of 200 mg on day one followed by 100 mg daily for four days (total five days), the new treatment protocols stated.

The Health Ministry on June 13 had allowed the use of remdesivir for restricted emergency use in moderate cases under "investigational therapies".

"Under emergency use authorisation, remdesivir may be considered for patients in moderate stage requiring oxygen support," the document stated.

It is not recommended for those with severe renal impairment and high level of liver enzymes, pregnant and lactating women, and those below 12 years, it said.

The ministry also okayed off-label application of tocilizumab, a drug that modifies the immune system or its functioning, and convalescent plasma for treating COVID-19 patients in the moderate stage of illness as "investigational therapies".

It also recommended hydroxychloroquine for patients during the early course of the disease and not for critically-ill patients.

On June 27, the ministry had included an inexpensive, widely used steroid dexamethasone in treatment protocols for COVID-19 patients in the moderate to severe stages of their illness among other therapeutic measures.

The ministry advised use of dexamethasone, which is already used in a wide range of conditions for its anti-inflammatory and immunosuppressant effects, as an alternative choice to methylprednisolone for managing moderate to severe cases of coronavirus infection.

India's COVID-19 cases soared by over 20,000 in a day for the first time taking the country's total tally to 6,25,544 on Friday while the death toll climbed to 18,213 with 379 new fatalities, according to the Union Health Ministry data updated at 8 am.

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Hubballi (Karnataka), Apr 18: The daughter of a Congress Corporator was stabbed to death by her acquaintance inside BVB college campus here on Thursday after she allegedly rejected his proposal, police said.

The deceased Neha (23), the daughter of Niranjan Hiremath, was a first-year MCA student, they said.

The accused 23-year-old Fayaz, an MCA dropout, has been arrested in connection with the incident, police said, adding that both of them were batchmates during their BCA course.

The entire incident was caught on CCTV camera.

According to the police, Fayaz went inside the college campus with a knife and stabbed Neha five-six times. During the attack, he too sustained injuries and was shifted to the hospital along with the victim. At the hospital, Neha was declared brought dead.

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"During interrogation, he (Fayaz) claimed that the two of them had been in a relationship and that she had suddenly started avoiding him. It needs to be corroborated and verified, but he was arrested immediately," a senior police officer said.

A case of murder has been registered, police said, adding that further investigation is underway.

Narrating about the incident, Neha's father Hiremath said that his daughter had classes from 8 am. At around 4.30 pm, when she stepped out after completing her classes, this person approached towards her and stabbed her nearly six times inside the college campus and she died on the spot.

"He (the accused) was an old student and he had proposed my daughter but she rejected his proposal. She did not like him and she usually stayed away from all this...She refused him saying they both belonged to different caste and that she did not wish to have any relationship with him. Out of anger, he stabbed my daughter," he told PTI videos.

Demanding justice for her daughter, he said that the accused should he hanged to death only then will his daughter's soul rest in peace.

Meanwhile, Karnataka Chief Minister Siddaramaiah condemned the incident and offered condolences to the family of the deceased.

"An accused has already been arrested in connection with the incident and I have instructed the Director General of Police to conduct a strict investigation and take action to ensure maximum punishment for the accused," he said in a post on 'X'.

He also appealed to people to not take law into their hands.

"In connection with the incident, no one should get agitated and take law into their hands or attempt to disturb peace of the society. It is our duty to get justice for the death of the young woman, in this regard the police department will work hard," he added.

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