Revolutionary Research on Personalized Cancer Treatment Using Zebrafish Avatar discussed at GMU
Ajman (Press Release): Gulf Medical's University and Thumbay Research Institute of Precision Medicine marked the Research Day, sharing insights from leading minds on the region’s first pilot research on personalized precision medicine programme using the Zebrafish Avatars to treat cancer- with the first phase focusing on the care of patients suffering from colorectal and breast cancer. The study’s findings aim to help researchers and oncology healthcare providers to design more tailored and effective treatments based on genetic screening, data on tumor progression and subsequently assessing the need and efficacy of chemotherapy versus other advanced surgical alternatives. In this way, the research further intends to reduce the trial-and-error response in oncology medicine combined with the preservation of organ function and, improve the overall quality of life.
Dr. Rita Fior, PhD, Group Leader Champalimaud Center for the Unknown, elaborated, “The research has been conducted by developing Zebrafish xenografts with a very clear goal of personalized medicine. We live in a world with such amazing technology that helps us to go to the moon, fly planes, zoom over the world, advanced technologies in biology, sequencing of whole genomes, etc. However, once a patient is diagnosed with cancer, they are most likely to be treated with chemo or radiotherapy- although many new amazing targeted therapies are being developed and great advances have been made. By directly challenging the cells and measuring the response to direct perturbation, we have found good predictive analysis that can aid the entire process of diagnostics, therapy, and tailor it to the needs of the specific
individual.”
An avatar is an animal that has been incubated with a person’s cancer cells so that doctors can test drug effectiveness on the animal tumor first. With several avatars, doctors can test several treatments. But obtaining a tumor assay from a mouse avatar could take months. And people fighting cancer don’t have months. In recent times, the Zebrafish has successfully created human cancer avatars where the tumors are ready to be assayed in just four days.
Speaking about the research, Professor Hossam Hamdy, chancellor, Gulf Medical University, said, “As the leading health professions’ education institution in UAE, Gulf Medical University looks forward to playing a central role in the advancement of oncology diseases research landscape, incorporating the rich multi-factorial data to tailor treatment and significantly reduce the risks associated with chemotherapy. We are confident that our work will contribute to UAE’s efforts in spearheading the growth and development of the healthcare sector.”
On similar lines, Prof. Salem Chouaib, Director of the Thumbay Research Institute for Precision Medicine, stated, “In every area of cancer, treatments have largely functioned on a one-size-fits-all basis because we didn’t have tools to do any better. Going forward, the advancements in precision medicine will help in determining whether patients are likely to benefit from a particular therapy, longer survival and fewer toxic effects of chemotherapy.”
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100 stray dogs ''poisoned'' to death near Hyderabad, case booked
Hyderabad (PTI): In yet another incident of stray dog killings, nearly 100 canines were allegedly "poisoned to death" in Yacharam village near here following which a case was registered against a sarpanch and two others for their alleged involvement in the act, police said on Wednesday.
The fresh incident follows killing of nearly 500 stray dogs in different districts of Telangana since January 6.
An animal welfare activist, associated with Stray Animal Foundation of India, in a complaint filed with Yacharam Police Station alleged that the dogs were injected with some poisonous substances on January 19.
A case was registered under relevant sections of BNS and Prevention of Cruelty of Animals Act against the sarpanch, secretary and ward member of Yacharam gram panchayat on Tuesday, a police official said.
As per the complainant, 100 dogs were killed, but based on preliminary investigation and after verifying with villagers around 50 dogs were found to be killed, though further probe is on in this regard, the official said.
An investigation is also underway to find out the carcasses of the dogs, he said.
Earlier, police in Hanamkonda district had booked nine persons, including two women sarpanches and their husbands, in connection with the alleged killing of around 300 stray dogs in Shayampet and Arepally villages.
In another incident, around 200 stray dogs were allegedly killed in Kamareddy district, and a case was booked against six persons, including five village sarpanches, for their alleged involvement in the incident.
It is suspected that some elected representatives, including sarpanches, allegedly carried out the killings to "fulfill promises made to villagers" ahead of gram panchayat elections held in December last year, to tackle the stray dog menace.
