Revolutionary Research on Personalized Cancer Treatment Using Zebrafish Avatar discussed at GMU
Ajman (Press Release): Gulf Medical's University and Thumbay Research Institute of Precision Medicine marked the Research Day, sharing insights from leading minds on the region’s first pilot research on personalized precision medicine programme using the Zebrafish Avatars to treat cancer- with the first phase focusing on the care of patients suffering from colorectal and breast cancer. The study’s findings aim to help researchers and oncology healthcare providers to design more tailored and effective treatments based on genetic screening, data on tumor progression and subsequently assessing the need and efficacy of chemotherapy versus other advanced surgical alternatives. In this way, the research further intends to reduce the trial-and-error response in oncology medicine combined with the preservation of organ function and, improve the overall quality of life.
Dr. Rita Fior, PhD, Group Leader Champalimaud Center for the Unknown, elaborated, “The research has been conducted by developing Zebrafish xenografts with a very clear goal of personalized medicine. We live in a world with such amazing technology that helps us to go to the moon, fly planes, zoom over the world, advanced technologies in biology, sequencing of whole genomes, etc. However, once a patient is diagnosed with cancer, they are most likely to be treated with chemo or radiotherapy- although many new amazing targeted therapies are being developed and great advances have been made. By directly challenging the cells and measuring the response to direct perturbation, we have found good predictive analysis that can aid the entire process of diagnostics, therapy, and tailor it to the needs of the specific
individual.”
An avatar is an animal that has been incubated with a person’s cancer cells so that doctors can test drug effectiveness on the animal tumor first. With several avatars, doctors can test several treatments. But obtaining a tumor assay from a mouse avatar could take months. And people fighting cancer don’t have months. In recent times, the Zebrafish has successfully created human cancer avatars where the tumors are ready to be assayed in just four days.
Speaking about the research, Professor Hossam Hamdy, chancellor, Gulf Medical University, said, “As the leading health professions’ education institution in UAE, Gulf Medical University looks forward to playing a central role in the advancement of oncology diseases research landscape, incorporating the rich multi-factorial data to tailor treatment and significantly reduce the risks associated with chemotherapy. We are confident that our work will contribute to UAE’s efforts in spearheading the growth and development of the healthcare sector.”
On similar lines, Prof. Salem Chouaib, Director of the Thumbay Research Institute for Precision Medicine, stated, “In every area of cancer, treatments have largely functioned on a one-size-fits-all basis because we didn’t have tools to do any better. Going forward, the advancements in precision medicine will help in determining whether patients are likely to benefit from a particular therapy, longer survival and fewer toxic effects of chemotherapy.”
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UP Cong holds statewide protest seeking probe into FIR against Swami Avimukteshwaranand
Lucknow (PTI): The Uttar Pradesh Congress on Wednesday staged a statewide protest demanding a fair and transparent inquiry into the FIR lodged against Swami Avimukteshwaranand Saraswati and those who filed the complaint against him.
In a statement issued here, the party said memorandums addressed to Prime Minister Narendra Modi were submitted through district magistrates in all districts of the state.
Uttar Pradesh Congress spokesperson Manish Hindvi told PTI that the memorandums were handed over through the district administration in all 75 districts.
In the memorandum, the party alleged that Saraswati and his disciples were "unnecessarily harassed and humiliated" by police on the occasion of Amavasya and were prevented from taking a ritual bath (at the Magh Mela). It further alleged that some disciples were manhandled and taken to a police station.
The memorandum also claimed that an FIR was later registered against Saraswati, his disciple Swami Mukundanand Brahmachari and several unidentified persons in a sexual harassment case. It termed the case a "conspiracy" aimed at tarnishing the seer's reputation.
Citing Articles 25 and 26 of the Constitution, the memorandum stated that these provisions guarantee religious freedom and the right of religious denominations to manage their own affairs.
It described the position of shankaracharya held by Saraswati as "one of the highest spiritual posts in Sanatan tradition" and alleged that the entire episode appeared to have been "orchestrated in a planned manner".
"We request that the background of the persons who got the FIR registered be investigated in a transparent manner by a retired high court judge and strict action be taken against them," the memorandum said.
It also sought a "fair and transparent probe" into the allegations levelled against Saraswati so that the truth could be established.
Earlier, Uttar Pradesh Congress president Ajay Rai had told reporters in Varanasi after meeting Saraswati that the party stood firmly with him.
The Congress said it would continue to press for an impartial inquiry into the entire episode.
On February 21, an FIR was lodged in Prayagraj against Saraswati and his disciple Mukundanand Brahmachari on charges of sexually abusing two persons, including a minor, over the past year at a gurukul and religious congregations, including the recently concluded Magh Mela.
Days after he was booked, Saraswati had said on Monday that he would not oppose his arrest and asserted that the "fabricated story" would be exposed sooner or later.
At a press conference on Wednesday, Saraswati alleged that criminals rule in Uttar Pradesh, level allegations and influence investigations, as he denied having any contact with the two persons for whose alleged sexual abuse he has been booked.
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