Revolutionary Research on Personalized Cancer Treatment Using Zebrafish Avatar discussed at GMU
Ajman (Press Release): Gulf Medical's University and Thumbay Research Institute of Precision Medicine marked the Research Day, sharing insights from leading minds on the region’s first pilot research on personalized precision medicine programme using the Zebrafish Avatars to treat cancer- with the first phase focusing on the care of patients suffering from colorectal and breast cancer. The study’s findings aim to help researchers and oncology healthcare providers to design more tailored and effective treatments based on genetic screening, data on tumor progression and subsequently assessing the need and efficacy of chemotherapy versus other advanced surgical alternatives. In this way, the research further intends to reduce the trial-and-error response in oncology medicine combined with the preservation of organ function and, improve the overall quality of life.
Dr. Rita Fior, PhD, Group Leader Champalimaud Center for the Unknown, elaborated, “The research has been conducted by developing Zebrafish xenografts with a very clear goal of personalized medicine. We live in a world with such amazing technology that helps us to go to the moon, fly planes, zoom over the world, advanced technologies in biology, sequencing of whole genomes, etc. However, once a patient is diagnosed with cancer, they are most likely to be treated with chemo or radiotherapy- although many new amazing targeted therapies are being developed and great advances have been made. By directly challenging the cells and measuring the response to direct perturbation, we have found good predictive analysis that can aid the entire process of diagnostics, therapy, and tailor it to the needs of the specific
individual.”
An avatar is an animal that has been incubated with a person’s cancer cells so that doctors can test drug effectiveness on the animal tumor first. With several avatars, doctors can test several treatments. But obtaining a tumor assay from a mouse avatar could take months. And people fighting cancer don’t have months. In recent times, the Zebrafish has successfully created human cancer avatars where the tumors are ready to be assayed in just four days.
Speaking about the research, Professor Hossam Hamdy, chancellor, Gulf Medical University, said, “As the leading health professions’ education institution in UAE, Gulf Medical University looks forward to playing a central role in the advancement of oncology diseases research landscape, incorporating the rich multi-factorial data to tailor treatment and significantly reduce the risks associated with chemotherapy. We are confident that our work will contribute to UAE’s efforts in spearheading the growth and development of the healthcare sector.”
On similar lines, Prof. Salem Chouaib, Director of the Thumbay Research Institute for Precision Medicine, stated, “In every area of cancer, treatments have largely functioned on a one-size-fits-all basis because we didn’t have tools to do any better. Going forward, the advancements in precision medicine will help in determining whether patients are likely to benefit from a particular therapy, longer survival and fewer toxic effects of chemotherapy.”
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House of Nagpur violence key accused likely to be demolished
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Nagpur (PTI): Civic authorities are on Monday likely to demolish the illegal portions of a house of Fahim Khan, a key accused in the Nagpur violence who has been booked for sedition, after he failed to remove the unauthorised structure.
Khan, a leader of the Minority Democratic Party (MDP), is among the over 100 persons arrested for the violence in Maharashtra's Nagpur city on March 17.
A few days back, the Nagpur Municipal Corporation issued a notice to Khan, citing various lapses and lack of the building plan approval (for his house), sources said.
The house, located at Sanjay Bagh Colony in Yashodhara Nagar area here, registered in the name of Khan's wife, they said.
MDP city chief Khan is currently lodged in a jail.
The violence erupted on March 17, after rumours spread that a ‘chadar’ with religious inscriptions had been burnt during protests led by the Vishwa Hindu Parishad (VHP) demanding the removal of Aurangzeb’s tomb in Chhatrapati Sambhajinagar.
The clashes resulted in widespread stone-pelting and arson across several parts of the city, leaving 33 police personnel, including three Deputy Commissioner of Police-rank officers, injured.
Chief Minister Devendra Fadnavis on Saturday said the cost of properties damaged during the violence will be recovered from rioters and the failure to pay up would lead to the seizure and selling of their properties to recover losses.
"My government will not rest until those responsible for attacking the police are found and dealt with sternly," said Fadnavis, who also heads the Home Ministry.
The CM said those who circulated inflammatory content would be charged as co-accused for their role in inciting violence.
Fadnavis also said it was too early to comment on a foreign or Bangladeshi link to the riots as the probe was underway.
"However, the Malegaon connection can be seen (in violence) as one of the accused belongs to a political party from Malegaon who could be seen helping rioters," he said without taking the name of Fahim Khan, arrested for sedition.
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