New York, July 14 : Examining stress and inflammation in the heart may be key to predicting risk of Parkinson's disease, say researchers, as it may help physicians test new therapies and delay the progression of the disorder.

According to researchers, by the time Parkinson's patients are diagnosed -- typically based on the tremors and motor-control symptoms -- about 60 per cent of them also have serious damage to the heart's connections to the sympathetic nervous system.

When healthy, those nerves spur the heart to accelerate its pumping to match quick changes in activity and blood pressure.

"This neural degeneration in the heart means patients' bodies are less prepared to respond to stress and to simple changes like standing up. They have increased risk for fatigue, fainting and falling that can cause injury and complicate other symptoms of the disease," said Marina Emborg, from the University of Wisconsin-Madison, US.

For the study, published in the journal npj Parkinson's Disease, the teams used rhesus macaque monkeys as models for Parkinson's symptoms, who received neurotoxin doses that caused damage to the nerves in their hearts in the same way as Parkinson's affects human patients.

The team found that tracing the progression of nerve damage and the progression of potential causes of that damage, the radioligands can also be used to test the efficacy of new treatments to protect the neurons that regulate the activity of the patients' hearts.

"We know there is damage in the heart in Parkinson's, but we haven't been able to look at exactly what's causing it. Now we can visualize in detail where inflammation and oxidative stress are happening in the heart, and how that relates to how Parkinson's patients lose those neuronal connections in the heart," said lead author Jeanette Metzger, from the varsity.

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Karwar: The District Disaster Management Authority (DDMA) of Uttara Kannada has issued a warning in light of heavy rainfall predicted by the Indian Meteorological Department and the Karnataka State Natural Disaster Management Centre. The coastal part of the state is expected to experience severe weather conditions over the next four days.

A Red Alert has been announced for today, July 14, 2024, and tomorrow, July 15, 2024

Precautionary Measures for the Public:

1. Avoid water bodies: The public and fishermen are advised to stay away from rivers, water bodies, and the sea.
2. Electrical hazards: Children and the public should avoid going near electric poles and stay clear of severed electric wires.
3. Structural safety: Avoid standing near or under trees, and stay away from fragile or old buildings.
4. Evacuation advisory: Residents in low-lying areas or those living in buildings at risk of collapsing due to the weather are advised to move to safe locations. Designated care centers identified by the concerned Tahsildar are available for shelter.

Emergency Contact:
In case of any emergency, residents are urged to contact the District Disaster Emergency Helpline at 1077 or 9483511015.

The DDMA stresses that these precautions must be followed diligently throughout the rainy season to ensure public safety.