Checking for heart damage may predict risk of Pakinson's later
New York, July 14 : Examining stress and inflammation in the heart may be key to predicting risk of Parkinson's disease, say researchers, as it may help physicians test new therapies and delay the progression of the disorder.
According to researchers, by the time Parkinson's patients are diagnosed -- typically based on the tremors and motor-control symptoms -- about 60 per cent of them also have serious damage to the heart's connections to the sympathetic nervous system.
When healthy, those nerves spur the heart to accelerate its pumping to match quick changes in activity and blood pressure.
"This neural degeneration in the heart means patients' bodies are less prepared to respond to stress and to simple changes like standing up. They have increased risk for fatigue, fainting and falling that can cause injury and complicate other symptoms of the disease," said Marina Emborg, from the University of Wisconsin-Madison, US.
For the study, published in the journal npj Parkinson's Disease, the teams used rhesus macaque monkeys as models for Parkinson's symptoms, who received neurotoxin doses that caused damage to the nerves in their hearts in the same way as Parkinson's affects human patients.
The team found that tracing the progression of nerve damage and the progression of potential causes of that damage, the radioligands can also be used to test the efficacy of new treatments to protect the neurons that regulate the activity of the patients' hearts.
"We know there is damage in the heart in Parkinson's, but we haven't been able to look at exactly what's causing it. Now we can visualize in detail where inflammation and oxidative stress are happening in the heart, and how that relates to how Parkinson's patients lose those neuronal connections in the heart," said lead author Jeanette Metzger, from the varsity.
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Regulator DGCA eases flight duty norms for pilots amid IndiGo crisis
Mumbai (PTI): Aviation watchdog DGCA on Friday eased the flight duty norms by allowing substitution of leaves with a weekly rest period amid massive operational disruptions at IndiGo, according to sources.
As per the revised Flight Duty Time Limitations (FDTL) norms, "no leave shall be substituted for weekly rest", which means that weekly rest period and leaves are to be treated separately. The clause was part of efforts to address fatigue issues among the pilots.
Citing IndiGo flight disruptions, sources told PTI that the Directorate General of Civil Aviation (DGCA) has decided to withdraw the provision 'no leave shall be substituted for weekly rest' from the FDTL norms.
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"In view of the ongoing operational disruptions and representations received from various airlines regarding the need to ensure continuity and stability of operations, it has been considered necessary to review the said provision," DGCA said in a communication dated December 5.
The gaps in planning ahead of the implementation of the revised FDTL, the second phase of which came into force from November 1, have resulted in crew shortage at IndiGo and is one of the key reasons for the current disruptions.
#BREAKING: #DGCA relaxes a clause which debarred airlines to club leaves with weekly rest to mitigate #IndiGo crisis
— Economic Times (@EconomicTimes) December 5, 2025
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