Coffee adversely impacts Alzheimer patients.
London, April 4: Regular intake of coffee or caffeine by patients with Alzheimer's disease may deteriorate their neuropsychiatric symptoms, including but not limited to anxiety, say researchers.
While it is well known that memory problems are the hallmarks of Alzheimer's disease, this dementia is also characterized by neuropsychiatric symptoms such as anxiety, apathy, depression, hallucinations, paranoid, sundowning and more known as Behavioral and Psychological Symptoms of Dementia (BPSD) which may be strongly present already in the first stages of the disorder.
The results indicate that caffeine worsened these symptoms in mice with Alzheimer's.
The researchers also discovered significant effects, especially in relation to neophobia -- a fear of everything new -- anxiety-related behaviours, and emotional and cognitive flexibility.
"The mice develop Alzheimer's disease in a very close manner to the human patients with early-onset form of the disease," said lead author Raquel Baeta-Corral from the Autonomous University of Barcelona in Spain.
"They not only exhibit the typical cognitive problems but also a number of Behavioural and Psychological Symptoms of Dementia (BPSD)-like symptoms, so it is a valuable model to address whether the benefits of caffeine will be able to compensate its putative negative effects."
For the study, the team analyzed the effect of caffeine on normal ageing mice and familial Alzheimer’s models.
However, coffee has also been suggested as a strategy to prevent dementia, both in patients with Alzheimer's disease and in normal ageing processes, due to its action in blocking molecules - adenosine receptors - which may cause dysfunctions and diseases in old age.
But "our observations of adverse caffeine effects in an Alzheimer's disease model together with previous clinical observations suggest that an exacerbation of BPSD-like symptoms may partly interfere with the beneficial cognitive effects of caffeine", the researchers said.
Let the Truth be known. If you read VB and like VB, please be a VB Supporter and Help us deliver the Truth to one and all.
3 Indians arrested in Canada for shooting outside home
Ottawa (PTI): Three Indian nationals have been arrested by Canadian police on an anti-extortion patrol and charged after bullets were fired at a home.
Harjot Singh (21), Taranveer Singh (19) and Dayajeet Singh Billing (21) face one count each of discharging a firearm, and all have been remanded in custody until Thursday, the Surrey Police Service (SPS) said in a statement on Monday.
The suspects were arrested by patrol officers after an early morning report of shots fired and a small fire outside a home in Surrey's Crescent Beach neighbourhood, the LakelandToday reported.
On February 1, 2026, the SPS members were patrolling in Surrey’s Crescent Beach neighbourhood when reports came in of shots being fired and a small fire outside a residence near Crescent Road and 132 Street.
The three accused were arrested by SPS officers a short time later, the statement said.
SPS’s Major Crime Section took over the investigation, and the three men have now been charged with Criminal Code offences, it said.
All three have been charged with one count each of discharging a firearm into a place contrary to section 244.2(1)(a) of the Criminal Code.
The investigation is ongoing, and additional charges may be forthcoming. All three have been remanded in custody until February 5, 2026.
The SPS has confirmed they are all foreign nationals and has engaged the Canada Border Services Agency, it said.
One of the suspects suffered injuries, including two black eyes, the media report said.
Surrey police Staff Sgt. Lindsey Houghton said on Monday that the suspect had refused to comply with instructions to get out of the ride-share vehicle and started to "actively resist."
"As we were trained, he was taken to the ground and safely handcuffed," said Houghton.
A second suspect with a black eye was also injured in the arrest after refusing to comply, Houghton said.
The arresting officers were part of Project Assurance, an initiative that patrols neighbourhoods that have been targeted by extortion violence.
Houghton said the Canada Border Services Agency (CBSA) is also involved because the men are foreign nationals, and the trio may face additional charges.
It's not clear if the men are in the country on tourist visas, a study permit, or a work permit, but Houghton said CBSA has started its own investigation into the men's status.
Surrey has seen a number of shootings at homes and businesses over the last several months, but there's been an escalation since the new year.
