Coffee adversely impacts Alzheimer patients.
London, April 4: Regular intake of coffee or caffeine by patients with Alzheimer's disease may deteriorate their neuropsychiatric symptoms, including but not limited to anxiety, say researchers.
While it is well known that memory problems are the hallmarks of Alzheimer's disease, this dementia is also characterized by neuropsychiatric symptoms such as anxiety, apathy, depression, hallucinations, paranoid, sundowning and more known as Behavioral and Psychological Symptoms of Dementia (BPSD) which may be strongly present already in the first stages of the disorder.
The results indicate that caffeine worsened these symptoms in mice with Alzheimer's.
The researchers also discovered significant effects, especially in relation to neophobia -- a fear of everything new -- anxiety-related behaviours, and emotional and cognitive flexibility.
"The mice develop Alzheimer's disease in a very close manner to the human patients with early-onset form of the disease," said lead author Raquel Baeta-Corral from the Autonomous University of Barcelona in Spain.
"They not only exhibit the typical cognitive problems but also a number of Behavioural and Psychological Symptoms of Dementia (BPSD)-like symptoms, so it is a valuable model to address whether the benefits of caffeine will be able to compensate its putative negative effects."
For the study, the team analyzed the effect of caffeine on normal ageing mice and familial Alzheimer’s models.
However, coffee has also been suggested as a strategy to prevent dementia, both in patients with Alzheimer's disease and in normal ageing processes, due to its action in blocking molecules - adenosine receptors - which may cause dysfunctions and diseases in old age.
But "our observations of adverse caffeine effects in an Alzheimer's disease model together with previous clinical observations suggest that an exacerbation of BPSD-like symptoms may partly interfere with the beneficial cognitive effects of caffeine", the researchers said.
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Gujarat HC orders man to deposit Rs 1 lakh for attending virtual proceedings from toilet
Ahmedabad, July 14 (PTI): The Gujarat High Court on Monday directed a man, facing contempt of court for attending a virtual court hearing while relieving himself on a toilet seat, to deposit Rs 1 lakh with the court's registry after observing that he was ready to tender an unconditional apology.
The incident occurred on June 20 when Justice Nirzar S Desai was hearing a case. A video of the man soon went viral, prompting the high court to initiate suo motu contempt proceedings.
On Monday, the division bench of Justices AS Supehia and RT Vachhani directed the man, identified as Samad Abdul Rehman Shah, to deposit Rs 1 lakh in the court registry by July 22, the next date of the hearing.
"The contemnor has admitted to his conduct during the live-streaming proceedings and submitted that he was ready to tender an unconditional apology. Thus, at this stage, we direct the contemnor to deposit the amount of Rs 1 lakh before the registry of this court by the next date of hearing," the court ordered.
According to the report submitted to the court, Shah attended the hearing on June 20 for a total of 74 minutes, during which he was seen sitting on a toilet and relieving himself.
Shah's lawyer told the court that his client would tender an unconditional apology for his behaviour.
When questioned, the lawyer confirmed he had advised Shah to present himself appropriately for the hearing.
The now-infamous video showed Shah using a toilet during the proceedings, sparking outrage and leading the court to order the video’s immediate removal and ban, citing damage to the judiciary’s image.
Since the COVID-19 pandemic, the Gujarat High Court has permitted lawyers and litigants to join hearings virtually. Proceedings are live-streamed via the court's YouTube channel.
After finishing his business, Shah was seen picking up his phone and leaving. Justice Desai appeared unaware of his surroundings at the time.
Wearing wireless earphones, he can be seen logging in again later in the livestream, sitting in a room and waiting for his turn.
After nearly 10 minutes, he identified himself as Abdul Samad Shah, a resident of Kim village in Surat and the complainant in an assault case.
His lawyers told the court that Shah had lodged a complaint against two individuals but that a compromise had been reached between both parties.
While hearing the petition filed by the accused seeking to quash the FIR, Justice Desai asked Shah if he consented to the plea. Upon hearing Shah’s no-objection, the judge approved the petition.
