Coffee adversely impacts Alzheimer patients.
London, April 4: Regular intake of coffee or caffeine by patients with Alzheimer's disease may deteriorate their neuropsychiatric symptoms, including but not limited to anxiety, say researchers.
While it is well known that memory problems are the hallmarks of Alzheimer's disease, this dementia is also characterized by neuropsychiatric symptoms such as anxiety, apathy, depression, hallucinations, paranoid, sundowning and more known as Behavioral and Psychological Symptoms of Dementia (BPSD) which may be strongly present already in the first stages of the disorder.
The results indicate that caffeine worsened these symptoms in mice with Alzheimer's.
The researchers also discovered significant effects, especially in relation to neophobia -- a fear of everything new -- anxiety-related behaviours, and emotional and cognitive flexibility.
"The mice develop Alzheimer's disease in a very close manner to the human patients with early-onset form of the disease," said lead author Raquel Baeta-Corral from the Autonomous University of Barcelona in Spain.
"They not only exhibit the typical cognitive problems but also a number of Behavioural and Psychological Symptoms of Dementia (BPSD)-like symptoms, so it is a valuable model to address whether the benefits of caffeine will be able to compensate its putative negative effects."
For the study, the team analyzed the effect of caffeine on normal ageing mice and familial Alzheimer’s models.
However, coffee has also been suggested as a strategy to prevent dementia, both in patients with Alzheimer's disease and in normal ageing processes, due to its action in blocking molecules - adenosine receptors - which may cause dysfunctions and diseases in old age.
But "our observations of adverse caffeine effects in an Alzheimer's disease model together with previous clinical observations suggest that an exacerbation of BPSD-like symptoms may partly interfere with the beneficial cognitive effects of caffeine", the researchers said.
Let the Truth be known. If you read VB and like VB, please be a VB Supporter and Help us deliver the Truth to one and all.
Delhi polls: AAP releases 1st list of 11 candidates, fields BJP, Cong turncoats
New Delhi, Nov 21: The Aam Aadmi Party on Thursday announced its first list of 11 candidates for the Delhi Assembly polls, dropping three sitting MLAs and fielding six leaders who switched over from the BJP and the Congress recently.
Elections in the national capital are due in February to elect 70 members of the Delhi Legislative Assembly. AAP is the first party to release a list of candidates.
Making the announcement at a press conference here, Delhi AAP convener Gopal Rai reasoned that the early declaration of names of candidates was because eight of the 11 constituencies are not held by the party.
Six of these eight constituencies are currently held by the BJP.
He also rebutted suggestions that outsiders who recently joined AAP were given tickets at the cost of party leaders.
The names of candidates were announced after a meeting of the AAP's political affairs committee, headed by party national convener Arvind Kejriwal. AAP, which has been ruling Delhi since 2015, won 62 seats in the 2020 assembly polls.
Talking to reporters, Rai said the tickets were given strictly based on performance, surveys and public opinion as was promised by Kejriwal.
Sitting AAP MLAs who were denied tickets include Rituraj Jha from Kirari, Gulab Singh Yadav from Matiala and Abdul Rahman from Seelampur. Both Jha and Gulab Singh are two-term MLAs.
The party fielded Brahm Singh Tanwar from Chhatarpur, Anil Jha from Kirari and BB Tyagi from Laxmi Nagar. All three recently quit the BJP and joined AAP.
Former Congress leader Choudhary Zubair Ahmed has been fielded from Seelampur, while ex-MLAs Veer Singh Dhingan and Somesh Shokeen have been given tickets from Seemapuri and Matiala respectively. Ahmed, Dhingan and Shokeen joined the Aam Aadmi Party from the Congress.
AAP MLA from Chhatarpur Kartar Singh Tanwar quit the party and joined the BJP. He was disqualified as MLA by the Speaker.
Rajender Pal Gautam, AAP MLA from Seemapuri, resigned from the membership of the Delhi Assembly and the party to join the Congress.
Former AAP MLA Sarita Singh (Rohtas Nagar), Ram Singh Netaji (Badarpur), Gaurav Sharma (Ghonda), Manoj Tyagi (Karawal Nagar) and Deepak Singhal (Vishwas Nagar) are the other candidates whose names figure in the first list.
The party fielded Sarita Singh and Ram Singh Netaji again from Rohtas Nagar and Badarpur, respectively. They lost to their BJP rivals in the 2020 Assembly polls with narrow margins.
Rai said that the party has paced its election campaign with the release of these 11 names, adding that in the coming days, AAP will start a new campaign.
First list of AAP candidates for Delhi Elections is OUT‼️
— AAP (@AamAadmiParty) November 21, 2024
All the best to all the candidates ✌️🏻
फिर लायेंगे केजरीवाल ! 🔥#PhirLayengeKejriwal pic.twitter.com/YTbnqpzqEC
