London, April 4: Regular intake of coffee or caffeine by patients with Alzheimer's disease may deteriorate their neuropsychiatric symptoms, including but not limited to anxiety, say researchers.

 While it is well known that memory problems are the hallmarks of Alzheimer's disease, this dementia is also characterized by neuropsychiatric symptoms such as anxiety, apathy, depression, hallucinations, paranoid, sundowning and more known as  Behavioral and Psychological Symptoms of Dementia (BPSD) which may be strongly present already in the first stages of the disorder.

The results indicate that caffeine worsened these symptoms in mice with Alzheimer's.

The researchers also discovered significant effects, especially in relation to neophobia -- a fear of everything new -- anxiety-related behaviours, and emotional and cognitive flexibility.

"The mice develop Alzheimer's disease in a very close manner to the human patients with early-onset form of the disease," said lead author Raquel Baeta-Corral from the Autonomous University of Barcelona in Spain.

"They not only exhibit the typical cognitive problems but also a number of Behavioural and Psychological Symptoms of Dementia (BPSD)-like symptoms, so it is a valuable model to address whether the benefits of caffeine will be able to compensate its putative negative effects."

For the study, the team analyzed the effect of caffeine on normal ageing mice and familial Alzheimer’s models.

However, coffee has also been suggested as a strategy to prevent dementia, both in patients with Alzheimer's disease and in normal ageing processes, due to its action in blocking molecules - adenosine receptors - which may cause dysfunctions and diseases in old age.

But "our observations of adverse caffeine effects in an Alzheimer's disease model together with previous clinical observations suggest that an exacerbation of BPSD-like symptoms may partly interfere with the beneficial cognitive effects of caffeine", the researchers said.

 

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Bengaluru: The Karnataka Cabinet has approved a formation of separate Dharwad city corporation. Alongside, a 15% hike in fares across the four state transport corporations was also approved. The revised fares will come into effect on January 5.

Law and Parliamentary Affairs Minister H.K. Patil, addressing the media at the Committee Hall of Vidhana Soudha, provided details about the decision. He explained that the last fare revision for BMTC was a decade ago when diesel cost Rs 60.98 per litre. Since then, operational costs have risen significantly.

Diesel expenditure for the four corporations has increased from Rs 9.16 crore to Rs 13.21 crore, and personnel costs have grown from Rs 12.85 crore to Rs 18.36 crore. The daily operational burden now stands at Rs 9.56 crore. The fare hike is expected to generate an additional Rs 74.85 crore in monthly revenue without burdening the state exchequer, as Rs 5,015 crore has already been allocated for the Shakti Yojana this fiscal year.

Minister Patil announced that the Cabinet has decided to bifurcate the Hubballi-Dharwad Municipal Corporation into two independent municipal bodies.

The Cabinet approved the construction of a fishing port in Hejamady village, Udupi, with a revised estimate of Rs 209.13 crore. Additionally, Rs 84.57 crore has been sanctioned for the modernization and dredging of fishing ports.

In a move to strengthen cow shelters, Rs 10.50 crore has been allocated for projects in 14 districts. The Cabinet also approved constructing a building for Visvesvaraya Technical University in Chikkaballapur district at Rs 149.75 crore.

The Cabinet sanctioned a state-of-the-art bus stand in Bannimantap, Mysuru, at a cost of Rs 120 crore. Spread over 14 acres, the facility will include a divisional office, bus units, and commercial shops.

Approval was also granted to utilize Rs 137.85 crore, provided by the Union Finance Ministry under the Special Capital Assistance Scheme, for capital expenditure.

The Kalyana Karnataka Regional Development Board will use Rs 56.92 crore from its SCP/TSP scheme to supply bed sheets, mosquito nets, and clothing to government residential schools and hostels.

The Cabinet approved Rs 100 crore to construct new buildings for 200 veterinary institutions currently housed in rented or dilapidated structures, using NABARD assistance.

In Davangere, a site was allotted to the Karnataka Working Journalists' Association for constructing a civic facility. A plot in Avaragere village was also leased for 30 years at a concessional rate to Nayaka Vidyarthi Nilaya.

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