Coffee adversely impacts Alzheimer patients.
London, April 4: Regular intake of coffee or caffeine by patients with Alzheimer's disease may deteriorate their neuropsychiatric symptoms, including but not limited to anxiety, say researchers.
While it is well known that memory problems are the hallmarks of Alzheimer's disease, this dementia is also characterized by neuropsychiatric symptoms such as anxiety, apathy, depression, hallucinations, paranoid, sundowning and more known as Behavioral and Psychological Symptoms of Dementia (BPSD) which may be strongly present already in the first stages of the disorder.
The results indicate that caffeine worsened these symptoms in mice with Alzheimer's.
The researchers also discovered significant effects, especially in relation to neophobia -- a fear of everything new -- anxiety-related behaviours, and emotional and cognitive flexibility.
"The mice develop Alzheimer's disease in a very close manner to the human patients with early-onset form of the disease," said lead author Raquel Baeta-Corral from the Autonomous University of Barcelona in Spain.
"They not only exhibit the typical cognitive problems but also a number of Behavioural and Psychological Symptoms of Dementia (BPSD)-like symptoms, so it is a valuable model to address whether the benefits of caffeine will be able to compensate its putative negative effects."
For the study, the team analyzed the effect of caffeine on normal ageing mice and familial Alzheimer’s models.
However, coffee has also been suggested as a strategy to prevent dementia, both in patients with Alzheimer's disease and in normal ageing processes, due to its action in blocking molecules - adenosine receptors - which may cause dysfunctions and diseases in old age.
But "our observations of adverse caffeine effects in an Alzheimer's disease model together with previous clinical observations suggest that an exacerbation of BPSD-like symptoms may partly interfere with the beneficial cognitive effects of caffeine", the researchers said.
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Hemant Karkare killed by RSS-linked cop, not Kasab: Maharashtra LoP Vijay Wadettiwar
BJP writes to ECI for action against Cong leader Wadettiwar for 'defaming' Ujjwal Nikam
Mumbai, May 5: The BJP has written to the Election Commission of India seeking action against Congress and the opposition leader, Vijay Wadettiwar, for allegedly peddling lies and defaming its Mumbai North Central nominee and ex-26/11 prosecution lawyer Ujjwal Nikam.
Wadettiwar, the leader of the opposition in the Maharashtra legislative assembly, purportedly called Nikam an "anti-national" and accused him of hiding the information that then Maharashtra ATS chief Hemant Karkare wasn't killed by Kasab's bullet during the 26/11 terror attack, but fell to a bullet of a policeman affiliated to RSS.
His allegations were based on the book "Who Killed Karkare" written by retired police officer SM Mushriff.
"As a responsible leader, the opposition leader should desist from making such comments that can help the enemy nation," Nikam said.
Terming Wadettiwar's statements as "false and not based on facts", Mumbai BJP president Ashish Shekar claimed they were aimed at defaming Ujjwal Nikam and inciting emotions.
"We have written to the Election Commission of India seeking action against Wadettiwar who is a star campaigner (of Congress) and also against the Congress party for peddling lies," he added.
Shelar further said (Ajmal) Kasab was sentenced to death for killing innocent people after following a due process of law.
Kasab was the lone terrorist who was captured alive by Mumbai Police during the 26/11 terror attack by Pakistani terrorists in which at least 166 people were killed and several others were injured.
Shelar wondered whether Shiv Sena (UBT) chief Uddhav Thackeray supported the statement made by the Congress leader.
A former special public prosecutor, Nikam had represented the state in high-profile cases like the Mumbai serial bomb blasts and the 2008 Mumbai terror attack.
He is making his political foray from Mumbai North Central seat on a BJP ticket and is pitted against city Congress chief Varsha Gaikwad.
