Coffee adversely impacts Alzheimer patients.
London, April 4: Regular intake of coffee or caffeine by patients with Alzheimer's disease may deteriorate their neuropsychiatric symptoms, including but not limited to anxiety, say researchers.
While it is well known that memory problems are the hallmarks of Alzheimer's disease, this dementia is also characterized by neuropsychiatric symptoms such as anxiety, apathy, depression, hallucinations, paranoid, sundowning and more known as Behavioral and Psychological Symptoms of Dementia (BPSD) which may be strongly present already in the first stages of the disorder.
The results indicate that caffeine worsened these symptoms in mice with Alzheimer's.
The researchers also discovered significant effects, especially in relation to neophobia -- a fear of everything new -- anxiety-related behaviours, and emotional and cognitive flexibility.
"The mice develop Alzheimer's disease in a very close manner to the human patients with early-onset form of the disease," said lead author Raquel Baeta-Corral from the Autonomous University of Barcelona in Spain.
"They not only exhibit the typical cognitive problems but also a number of Behavioural and Psychological Symptoms of Dementia (BPSD)-like symptoms, so it is a valuable model to address whether the benefits of caffeine will be able to compensate its putative negative effects."
For the study, the team analyzed the effect of caffeine on normal ageing mice and familial Alzheimer’s models.
However, coffee has also been suggested as a strategy to prevent dementia, both in patients with Alzheimer's disease and in normal ageing processes, due to its action in blocking molecules - adenosine receptors - which may cause dysfunctions and diseases in old age.
But "our observations of adverse caffeine effects in an Alzheimer's disease model together with previous clinical observations suggest that an exacerbation of BPSD-like symptoms may partly interfere with the beneficial cognitive effects of caffeine", the researchers said.
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Man arrested with Rs 2.54-crore heroin in Mumbai
Mumbai (PTI): Police have arrested a man and seized over 500 grams of heroin worth Rs 2.54 crore in the illicit market from him in Mumbai, officials said on Friday.
The police's Anti-Narcotics Cell (ANC) made the drug seizure in Santacruz in the western suburbs. The operation was conducted by the Kandivali unit of the ANC on Thursday as part of a special crackdown against drug trafficking in the area, they said.
Acting on specific inputs, an ANC team conducted a raid in Santacruz (East) and intercepted a man. During a search, the team recovered 508 grams of high-grade heroin from his possession, an official said.
The seized contraband, a highly addictive, opioid drug derived from morphine, is estimated to be worth Rs 2.54 crore in the international market, he informed.
Following the seizure, a case was registered against the man under relevant sections of the Narcotic Drugs and Psychotropic Substances (NDPS) Act, 1985, and he was formally placed under arrest in the early hours of Friday.
The police are currently investigating the source of the drug and trying to identify the intended recipients of the consignment, he said.
