How middle-age hypertension raises dementia risk later
London, June 13: A high blood pressure level but still below the usual threshold for treating hypertension can put 50-year-olds at increased risk of developing dementia later, revealed a study led by an Indian-origin researcher.
According to the American Heart Association, normal blood pressure is below 120/80 mmHg.
People with a systolic blood pressure (the top number) of 130 mmHg or more at the age of 50 had a 45 per cent greater risk of developing dementia than those with a lower level at the same age.
The risk was 47 per cent even in people with no heart or blood vessel-related conditions.
"Our work confirms the detrimental effects of midlife hypertension for risk of dementia," said lead author Archana Singh-Manoux, Professor at the French National Institute of Health and Medical Research (INSERM) in Paris.
The reason for the increased risk of dementia includes the fact that high blood pressure is linked to silent or mini strokes (where symptoms often are not noticeable), damage to the white matter in the brain, which contains many of the brain's nerve fibres, and restricted blood supply to the brain.
This damage may underlie the resulting decline in the brain's processes, the researchers explained in the study of nearly 9,000 people, published in the European Heart Journal.
However, the association was not seen at the ages of 60 and 70, and diastolic blood pressure (the bottom number) was not linked to dementia.
"Our analysis suggests that the importance of mid-life hypertension on brain health is due to the duration of exposure," the researcher said.
"So we see an increased risk for people with raised blood pressure at age 50, but not 60 or 70, because those with hypertension at age 50 are likely to be 'exposed' to this risk for longer," she added.
Another study reported in the journal Cardiovascular Research showed that higher risk of developing dementia in hypertensive patients occurs due to significant alterations in three specific white matter fibre-tracts linked to executive functions, processing speed, memory and related learning tasks -- brain areas associated with dementia.
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'Don't trust anybody before marriage': SC advises caution in pre-marital physical relationship
New Delhi (PTI): The Supreme Court on Monday said a boy and a girl before marriage are "total strangers" and they should be cautious while indulging in pre-marital physical relationships.
A bench of Justices B V Nagarathna and Ujjal Bhuyan, which was hearing the bail plea of a man accused of rape on a false promise of marriage, questioned the woman why she travelled all the way to Dubai where they indulged in physical relationship.
"It's consensual. We may be old-fashioned but a boy and girl before marriage are total strangers. They should be circumspect in indulging in physical relationships before marriage," the bench observed.
"Whatever may be the thick and thin of their relationship, we fail to understand how they can be indulging in physical relationship before marriage. Maybe we are old- fashioned but you must be very careful, nobody should believe anybody before marriage," Justice Nagarathna said.
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Counsel for the woman said they met on a matrimonial website in 2022 and he allegedly established physical relations with her on a false promise of marriage on multiple occasions in Delhi and later in Dubai.
Justice Nagarathna questioned the woman about what was the need for her to travel to Dubai and observed that it appears to be a case of consensual relationship.
"She should not have gone before marriage if she was so strict about it. We will send them to mediation. These are not cases which are to be tried and convicted when there is consensual relationship," she said.
Justice Nagarathna asked the counsel for the man to pay some compensation to her and be done with it.
The bench also asked the woman’s counsel to explore the possibility of settlement and posted the matter for hearing on Wednesday to see the views of both the parties. The woman has claimed in her complaint that on his insistence, she travelled to Dubai where he allegedly established physical relations with her on false pretext of marriage and recorded intimate videos without her consent, threatening to circulate them if she resisted.
The woman said that later she learnt that he had married a second woman in January, 2024 in Punjab.
The Delhi High Court and the trial court had dismissed the bail application of the man.
The high court rejected bail, saying the allegations prima facie indicate that the promise of marriage was false from inception, particularly as the petitioner was already married and had married again on January 19, 2024.
Aggrieved by the high court's order, the man approached the top court for bail in the case.
