How social isolation may increase stress
New York, May 18: Researchers have found that long term chronic isolation cause the build-up of a chemical in the brain, that increases stress, aggression and fear.
The mice isolated for two weeks showed behavioural changes like, increased aggressiveness towards unfamiliar mice, persistent fear, and hypersensitivity to threatening stimuli.
When encountering a threatening stimulus, mice that have been socially isolated remain frozen in place long after the threat has passed, whereas normal mice stop freezing soon after the threat is removed, the research said.
Although the study was done in mice, it has potential implications for understanding how chronic stress affects humans and has potential applications for treating mental health disorders, said lead author Moriel Zelikowsky, postdoctoral scholar at the California Institute of Technology in the US.
Previous studies have determined that social isolation for two weeks in mice resulted in the upregulation of the signalling molecule neuropeptide, tachykinin 2 (Tac2)/neurokinin B (NkB) -- a short protein molecule.
In the new study, published in the journal Cell, the team found that chronic isolation leads to an increase in Tac2 gene expression and the production of a neuropeptide called neurokinin B (NkB) throughout the brain.
But, administration of a drug that chemically blocks NkB-specific receptors enabled the stressed mice to behave normally, eliminating the negative effects of social isolation.
On the other hand, artificially increasing Tac2 levels and activating the corresponding neurons in normal, animals led them to behave like isolated and stressed, the research showed.
Suppressing the Tac2 gene in certain different brain parts, increased fear behaviours, or aggression accordingly, implying that it must increase in different brain regions to produce the various effects of social isolation, the researchers said.
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Three minor sisters die after jumping off ninth-floor in Ghaziabad
Ghaziabad (UP) (PTI): Three minor sisters died after allegedly jumping off the balcony of a ninth-floor flat in Ghaziabad early on Wednesday, police said.
Assistant Commissioner of Police (Shalimar Garden) Atul Kumar Singh said the police received information around 2.15 am about three girls jumping off the balcony of the ninth-floor apartment in a tower of Bharat City, located under the Teela Mor police station area.
On reaching the spot, the police found that the girls -- Nishika (16), Prachi (14) and Pakhi (12) -- daughters of Chetan Kumar, had fallen to the ground floor and suffered fatal injuries, the ACP said.
They were rushed by ambulance to a hospital in Loni, where doctors declared them dead on arrival, he added.
The police have initiated legal formalities and are investigating the circumstances leading to the incident, officials said.
