'Magical' royal bee jelly offers promise to combat cancer: Study
New York, July 23 : Royal jelly -- a natural bee product -- long known for its mysterious growth effects on future queen honey bees, while hailed by some as an anti-ageing, cholesterol-lowering super supplement, might also help fight cancer, finds new research.
Royal jelly also called "bee milk", looks like white snot. Besides water, it also contains a combination of proteins and sugars.
The findings showed this "queen magic" affects cell signalling and growth in cancer cells.
However, how this actually happens and its potential benefit to humans, has remained a mystery to scientists.
"The exact structure of the key protein in royal jelly remains unknown. But it is expected to act through the epidermal growth factor (or EGF) receptor -- the main pathway targeted by cancer therapeutics today," Daryl Klein, Assistant Professor at Yale University in Connecticut, US, said in a statement.
Klein's lab studies cell signalling, and how these signals can be "tuned" in different ways.
Using commercial jelly shipped from China, initial studies from Klein's lab have started to resolve the oligomer structure of MRJP-1 (major royal jelly protein).
However, the scientists found that resolution stalled around 11 Angstroms -- not enough to reveal the potential secrets hidden in the jelly.
They fear that the commercially available product may have been the limiting factor.
"We've bought commercial royal jelly, but it goes through a lot of handling -- freezing, thawing and re-freezing -- before it gets to us, which could affect the ultimate resolution we can see in this protein and how we can do functional tests on it," added Tongqing Li, post-doctoral associate at the varsity.
Researchers are now hoping to extract royal jelly from the university's campus to find out "how it modifies cell growth across different species, and how it might modify cancer cell signalling," Klein said.
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Narine stars as KKR beat LSG by 98 runs, go to top of table
Lucknow, May 5: Sunil Narine's sparkling fifty and a collective effort by the bowlers fashioned Kolkata Knight Riders' 98-run win over Lucknow Super Giants in the IPL here on Sunday.
Deciding to bowl first didn't go as per plan for LSG as KKR became the first team to cross the 200-run mark at the Ekana stadium.
Proving his worth with the willow once again, Narine (81 off 38 balls) went on a six-hitting spree, blasting seven maximums and six fours to take the visitors to 235/6.
Chasing an imposing total, LSG batters had to go from the word go but the hosts found it hard to get the big shots and were eventually bundled out for 137 in 16.1 overs.
Within the first 10 overs, LSG had lost half the side including skipper KL Rahul (25), Arshin Kulkarni (9), Deepak Hooda (5) and big hitters Marcus Stoinis (36) and Nicholas Pooran (10).
Ashton Turner hit some lusty blows and looked in mood to showcase his batting prowess but the Australian was supremely unlucky as an inside edge deflected off his boot with Varun Chakravarthy completing a caught and bowled.
With the win KKR moved to the top of the table. They have 16 points, the same as Rajasthan Royals but have played one game more.
LSG, on the other hand, dropped out of the top four to the fifth spot with 12 points from 11 games. Their Net Run Rate also took a massive hit going down from 0.094 to -0.371.
Earlier, the in-form Narine, who was dropped twice in the space of two balls, smoked five boundaries in five balls, setting the tone for the KKR innings.
First, he hammered back-to-back fours off Naveen-ul-Haq in the last two balls of the third over. He then attacked the offside, hitting three boundaries on the trot off Mohsin Khan in the fourth over.
Narine and Phil Salt (32) gave the two-time champions the explosive start they have come to expect from the duo. Together they put up a quick 61-run stand before Naveen-ul Haq took the pace off the ball to send the Englishman packing.
Medium pacer Yash Thakur then stemmed the flow of runs in the final over of the powerplay, giving away only two runs as KKR reached 70/1.
However, the unperturbed Narine continued his onslaught and brought up his fifty off 27 deliveries with a cheeky late dab that sent the ball rolling past short third.
He took a particular liking to Marcus Stoinis, sending the ball over the fence three times in the 11th over.
But Ravi Bishnoi, on whose bowling Narine was dropped twice before, was third time lucky as he put an end to the all-rounder's spectacular innings.
The LSG bowlers were able to rein in the KKR batters as they kept taking wickets.
Naveen-ul Haq got rid of Andre Russell (12) before Yudhvir Singh, who came as a concussion sub for Mohsin Khan, picked up young Angkrish Raghuvanshi's (32) wicket in the next over.
The Afghan pacer swung back into action to account for the big-hitting Rinku Singh (16) while Thakur removed Shreyas Iyer (23).
But Ramandeep Singh's unbeaten 25 off 6 balls took KKR past the 230-run mark.
