'Magical' royal bee jelly offers promise to combat cancer: Study
New York, July 23 : Royal jelly -- a natural bee product -- long known for its mysterious growth effects on future queen honey bees, while hailed by some as an anti-ageing, cholesterol-lowering super supplement, might also help fight cancer, finds new research.
Royal jelly also called "bee milk", looks like white snot. Besides water, it also contains a combination of proteins and sugars.
The findings showed this "queen magic" affects cell signalling and growth in cancer cells.
However, how this actually happens and its potential benefit to humans, has remained a mystery to scientists.
"The exact structure of the key protein in royal jelly remains unknown. But it is expected to act through the epidermal growth factor (or EGF) receptor -- the main pathway targeted by cancer therapeutics today," Daryl Klein, Assistant Professor at Yale University in Connecticut, US, said in a statement.
Klein's lab studies cell signalling, and how these signals can be "tuned" in different ways.
Using commercial jelly shipped from China, initial studies from Klein's lab have started to resolve the oligomer structure of MRJP-1 (major royal jelly protein).
However, the scientists found that resolution stalled around 11 Angstroms -- not enough to reveal the potential secrets hidden in the jelly.
They fear that the commercially available product may have been the limiting factor.
"We've bought commercial royal jelly, but it goes through a lot of handling -- freezing, thawing and re-freezing -- before it gets to us, which could affect the ultimate resolution we can see in this protein and how we can do functional tests on it," added Tongqing Li, post-doctoral associate at the varsity.
Researchers are now hoping to extract royal jelly from the university's campus to find out "how it modifies cell growth across different species, and how it might modify cancer cell signalling," Klein said.
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LoP Ashoka targets CM govt over corruption, says being 'shameless' in public life not forgivable
Bengaluru (PTI): Targeting Chief Minister Siddaramaiah and the Congress government in Karnataka on corruption, BJP leader R Ashoka on Friday said, being foolish was forgivable, but being "shameless" in public life was not.
The Leader of Opposition in the state Assembly claimed that in just 30 months of its tenure, the Congress administration has broken every previous record on corruption-related controversies.
He was responding to Siddaramaiah's post on 'X' on Thursday hitting back at the BJP, stating that Upa Lokayukta Justice Veerappa's claims of "63 per cent corruption" were based on his report in November 2019, when BJP's B S Yediyurappa was the CM.
"But Ashoka, without understanding the Upa Lokayukta's statement properly, has ended up tying the BJP's own bells of sins onto our heads and has effectively shot himself in the foot," the CM had said, as he accused Ashoka of foolishness for trying to twist Veerappa's statement to target the current government.
Responding, Ashoka said, "it is one thing to be called foolish in politics, that can be forgiven."
"But in public life, especially in the Chief Minister's chair, one must never become shameless," Ashoka posted on 'X' on Friday addressing Siddaramaiah.
Noting that the CM himself had admitted on the floor of the Assembly that a Rs 87 crore scam took place in the Valmiki Development Corporation, he said that when a CM acknowledges such a massive irregularity inside the floor of the House, the natural expectation is immediate action and accountability.
"But instead of taking responsibility, you continue in office as if nothing has happened. What should the people of Karnataka call this, if not sheer shamelessness," he asked.
Pointing out that the CM's Economic Advisor and senior Congress MLA Basavaraja Rayareddy had publicly stated that under Congress rule, Karnataka has become No.1 in corruption, Ashoka said, "Yet, you still cling to the Chief Minister's chair without a moment of introspection. What should the people of Karnataka call this, if not sheer shamelessness."
Senior Congress MLA C R Patil had exposed the "money for House" racket in the Housing Department and even warned that the government would collapse if the details he has were made public, Ashoka said.
"Despite such serious allegations from within your own party (Congress), you neither initiated an inquiry nor acted against the concerned minister. What should the people of Karnataka call this, if not sheer shamelessness," Ashoka asked the CM.
Highlighting the "40 percent commission" allegation Congress made against the previous BJP government, the opposition leader said, the commission that the Siddaramaiah government appointed concluded that the accusation was baseless.
"After your own panel demolished your own claim, what moral right do you have to continue repeating that allegation. What should the people of Karnataka call this, if not sheer shamelessness," he asked.
For the last two and a half years, Karnataka has been 'drowning' in corruption, scandals, irregularities and allegations across departments. Ashoka said, "If I begin listing every case that emerged under your government, even 24 hours would not be enough."
"And the most tragic aspect of your administration is this: the unbearable pressure, corruption demands and administrative harassment under your government pushed several officers and contractors into extreme distress - including the suicide of Chandrasekharan which exposed the Valmiki Development Corporation scam - a sign of how deeply broken the system has become under your watch," he said.
Instead of fixing this hopeless environment, the government has tried to bury every complaint and silence every voice, he charged.
"Being foolish is forgivable, but being shameless in public life is definitely not."
"When your own ministers admit scams, when your own advisors certify Karnataka as No.1 in corruption, and when your own MLAs expose rackets inside your departments - clinging to power without accountability is not leadership. It is shamelessness in its purest form." PTI KSU
Earlier on Thursday Ashoka had demanded that the corruption case and allegations in the state against the Congress government be handed over to a CBI investigation, citing a reported statement by Upalokaykta Justice Veerappa alleging "63 per cent corruption", following which Siddaramaiah hit back at the BJP leader.
