'Magical' royal bee jelly offers promise to combat cancer: Study
New York, July 23 : Royal jelly -- a natural bee product -- long known for its mysterious growth effects on future queen honey bees, while hailed by some as an anti-ageing, cholesterol-lowering super supplement, might also help fight cancer, finds new research.
Royal jelly also called "bee milk", looks like white snot. Besides water, it also contains a combination of proteins and sugars.
The findings showed this "queen magic" affects cell signalling and growth in cancer cells.
However, how this actually happens and its potential benefit to humans, has remained a mystery to scientists.
"The exact structure of the key protein in royal jelly remains unknown. But it is expected to act through the epidermal growth factor (or EGF) receptor -- the main pathway targeted by cancer therapeutics today," Daryl Klein, Assistant Professor at Yale University in Connecticut, US, said in a statement.
Klein's lab studies cell signalling, and how these signals can be "tuned" in different ways.
Using commercial jelly shipped from China, initial studies from Klein's lab have started to resolve the oligomer structure of MRJP-1 (major royal jelly protein).
However, the scientists found that resolution stalled around 11 Angstroms -- not enough to reveal the potential secrets hidden in the jelly.
They fear that the commercially available product may have been the limiting factor.
"We've bought commercial royal jelly, but it goes through a lot of handling -- freezing, thawing and re-freezing -- before it gets to us, which could affect the ultimate resolution we can see in this protein and how we can do functional tests on it," added Tongqing Li, post-doctoral associate at the varsity.
Researchers are now hoping to extract royal jelly from the university's campus to find out "how it modifies cell growth across different species, and how it might modify cancer cell signalling," Klein said.
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Fire in coach of New Delhi-Chennai express train; no casualty
Nagpur (PTI): A coach of the New Delhi-Chennai Grant Trunk Express caught fire in Maharashtra's Wardha district on Tuesday morning, railway officials said.
There were no casualties, they said.
Train 12616 New Delhi-Chennai (Tambaram) Grant Trunk Express left from Nagpur in the morning. While it was heading towards Sindi railway station in Wardha, smoke was detected in the last guard coach of the train at 11.09 am, Central Railway spokesperson Sanjay Muley told PTI.
The train was stopped on the Sindi-Tuljapur section, the affected coach was detached immediately, and the fire brigade was called, he said.
All passengers in the train and the coach concerned were safe, the official said.
The cause of the fire will be known after a detailed investigation.
The train will resume its journey in some time without the affected coach, the official added.
