Nano bubbles filled with drug may kill cancer cells: Study
Sydney, July 16 : In a step further to identify range of cancer treatments available to patients, scientists have developed drug-filled nano bubbles triggered in the body by X-rays which may help kill the malignant cells.
The tiny bubbles, known as liposomes, are commonly used in pharmacology to encapsulate drugs, making them more effective in the treatment of disease and researchers have now been able to engineer these liposomes to discharge their drug cargo on-demand, once activated by standard X-rays. Initial testing has shown this technique to be highly efficient in killing bowel cancer cells.
"The development and application of various nanomaterial designs for drug delivery is currently a key focus area in nanomedicine," said lead author Wei Deng, fro ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP), Australia.
"Liposomes are already well established as an extremely effective drug-delivery system. Made out of similar material as cell membranes, these 'bubbles' are relatively simple to prepare, can be filled with appropriate medications and then injected into specific parts of the body. The issue however, is in controlling the timely release of the drug from the liposome," Deng added.
For the study, published in the journal Nature Communications, the team embeded gold nanoparticles and the photo-sensitive molecule verteporfin into the wall of the liposome, in a laboratory setting
The X-ray radiation caused the verteporfin to react and produce highly reactive singlet oxygen which destabilisesdthe liposomal membrane, causing the release of the drug, Deng explained.
"The gold nanoparticles are added into the mix as they focus the X-ray energy. This enhances the singlet oxygen generation and hence improves the speed of the membrane breakup," she added.
The liposomes were filled with chemotherapy drug called doxorubicin, which killed the cancer cells far more effectively than without X-ray triggering
Thus, controlling the timely release of the drug from the bubble is very crucial, Deng said.
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Mangaluru: Nigerian national arrested for alleged drug trafficking
Mangaluru: The Mangaluru CCB police have successfully tracked down a Nigerian national residing in Goa, who was supplying cocaine from Goa to Mangaluru city, and seized 30 grams of cocaine.
The arrested accused has been identified as Michael Okfar Odikpo (44), a Nigerian national.
In March 2024, the Mangaluru CCB police arrested Sadaqat Shan Nawaz and Ashfaq, residents of Amblamogaru, who were illegally selling cocaine on a two-wheeler near Yeliarpadav Maidan in Amblamogaru village, Ullal. It was revealed that they had procured the cocaine from Goa. 34 grams of cocaine and other items worth ₹2,72,000 were seized from the duo, and a case was registered at the CEN Crime Police Station.
In connection with this case, the Mangaluru CCB police gathered information about the Goan drug supplier and successfully arrested him from Calangute in North Goa.
From the possession of the accused, the police seized 30 grams of cocaine, a car used for transportation, two mobile phones, ₹4,500 in cash, and a digital weighing scale. The total value of the seized items is estimated at ₹11,25,000. The accused has been handed over to the CEN Crime Police Station for further action.
The investigation revealed that the accused came to India in 2012 on a business visa and stayed in Mumbai for about one and a half years before moving to Goa, where he was allegedly involved in drug trafficking. A total of three cases of drug trafficking have been registered against him in Goa.
The operation was led by ACP Manoj Kumar Naik, with the team comprising Police Inspector Shyam Sundar HM, PSI Sharanappa Bhandary, and CCB personnel.
