New smart bandage may monitor, medicate chronic wounds
New York, July 7: Researchers have developed a prototype bandage designed to actively monitor the condition of chronic wounds and deliver appropriate drug treatments to improve the chances of healing.
While the lab-tested bandages remain to be assessed in a clinical context, a study, published in the journal Small, said the aim is to transform bandaging from a traditionally passive treatment into a more active paradigm to address a persistent and difficult medical challenge.
According to the researchers, chronic skin wounds from burns, diabetes and other medical conditions can overwhelm the regenerative capabilities of the skin and often lead to persistent infections and amputations.
"We have been able to take a new approach to bandages because of the emergence of flexible electronics," said co-author Sameer Sonkusale, Professor at Tufts University in the US.
The researchers designed the bandages with heating elements and thermoresponsive drug carriers that can deliver tailored treatments in response to embedded pH and temperature sensors that track infection and inflammation.
They said that pH of a chronic wound is one of the key parameters for monitoring its progress. Normal healing wounds fall within the range of pH 5.5 to 6.5, whereas non-healing infected wounds can have pH well above 6.5.
Temperature is also an important parameter, providing information on the level of inflammation in and around the wound, they added.
While the smart bandages in this study combine pH and temperature sensors, the team have also developed flexible sensors for oxygenation -- another marker of healing -- which can be integrated into the bandage.
Inflammation could also be tracked not just by heat, but by specific biomarkers as well, the researchers said.
A microprocessor reads the data from the sensors and can release drug on demand from its carriers by heating the gel.
The entire construct is attached to a transparent medical tape to form a flexible bandage less than 3 mm thick. Components were selected to keep the bandage cheap and disposable, except for the microprocessor, which can be re-used.
The researchers noted that smart bandages could provide real time monitoring and delivery of treatment with limited intervention from the patient or caregivers.
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Karnataka: Forest Minister Eshwar Khandre unveils plan for scientific disposal of plastic bottles
Bengaluru: In a bid to address the mounting plastic waste problem, Eshwar B. Khandre, Minister for Forests, Ecology, and Environment, has directed the additional chief secretary of the department to formulate regulations that will require packaged water bottle manufacturers to take responsibility for the scientific disposal of plastic bottles.
As part of the proposed plan, Khandre has suggested introducing a minimum price for each water bottle, which would be refunded when the bottle is returned to any establishment selling packaged water, as reported by Deccan Herald on Monday.
Under this initiative, when a person buys a new water bottle, the minimum price for each returned bottle would be discounted from the bill for the new one.
The goal is to ensure that empty bottles are returned to the shops where they were purchased, preventing them from being discarded in public spaces or ending up in the environment. Under the plan, these establishments would then return the empty bottles to manufacturers, who would be responsible for the scientific disposal of the plastic.
Khandre emphasised that the proposed regulations are aimed at tackling plastic pollution more effectively. Although the central government has already banned the manufacture, storage, sale, and use of certain single-use plastics, and the state government has enacted similar regulations, plastic waste continues to be a significant environmental challenge.
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