New smart bandage may monitor, medicate chronic wounds
New York, July 7: Researchers have developed a prototype bandage designed to actively monitor the condition of chronic wounds and deliver appropriate drug treatments to improve the chances of healing.
While the lab-tested bandages remain to be assessed in a clinical context, a study, published in the journal Small, said the aim is to transform bandaging from a traditionally passive treatment into a more active paradigm to address a persistent and difficult medical challenge.
According to the researchers, chronic skin wounds from burns, diabetes and other medical conditions can overwhelm the regenerative capabilities of the skin and often lead to persistent infections and amputations.
"We have been able to take a new approach to bandages because of the emergence of flexible electronics," said co-author Sameer Sonkusale, Professor at Tufts University in the US.
The researchers designed the bandages with heating elements and thermoresponsive drug carriers that can deliver tailored treatments in response to embedded pH and temperature sensors that track infection and inflammation.
They said that pH of a chronic wound is one of the key parameters for monitoring its progress. Normal healing wounds fall within the range of pH 5.5 to 6.5, whereas non-healing infected wounds can have pH well above 6.5.
Temperature is also an important parameter, providing information on the level of inflammation in and around the wound, they added.
While the smart bandages in this study combine pH and temperature sensors, the team have also developed flexible sensors for oxygenation -- another marker of healing -- which can be integrated into the bandage.
Inflammation could also be tracked not just by heat, but by specific biomarkers as well, the researchers said.
A microprocessor reads the data from the sensors and can release drug on demand from its carriers by heating the gel.
The entire construct is attached to a transparent medical tape to form a flexible bandage less than 3 mm thick. Components were selected to keep the bandage cheap and disposable, except for the microprocessor, which can be re-used.
The researchers noted that smart bandages could provide real time monitoring and delivery of treatment with limited intervention from the patient or caregivers.
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Three minor sisters die after jumping off ninth floor of apartment in Ghaziabad
Ghaziabad (UP) (PTI): Three minor sisters died after allegedly jumping off the balcony of a ninth-floor flat in Ghaziabad early on Wednesday, police said.
Assistant Commissioner of Police (Shalimar Garden) Atul Kumar Singh said the police received information around 2.15 am about three girls jumping off the balcony of the ninth-floor apartment in a tower of Bharat City, located under the Teela Mor police station area.
On reaching the spot, the police found that the girls - Nishika (16), Prachi (14) and Pakhi (12) - daughters of Chetan Kumar, had fallen to the ground floor and suffered fatal injuries, the ACP said.
They were rushed by ambulance to a hospital in Loni, where doctors declared them dead on arrival, he added.
The police have initiated legal formalities and are investigating the circumstances leading to the incident, officials said.
(Assistance for overcoming suicidal thoughts is available on the state’s health helpline 104, Tele-MANAS 14416.)
