Novel regenerative bandage may heal diabetics' wounds faster
New York, June 12: Your painful, hard-to-treat sores may soon be a thing of the past as scientists have developed a regenerative bandage that may quickly heal them without using drugs, an advance which may help make healing of wounds in diabetics faster.
The study, published in the journal Proceedings of the National Academy of Sciences, showed that the bandage healed diabetic wounds 33 per cent faster than one of the most popular bandages currently on the market.
"The novelty is that we identified a segment of a protein in skin that is important to wound healing, made the segment and incorporated it into an antioxidant molecule that self-aggregates at body temperature to create a scaffold that facilitates the body's ability to regenerate tissue at the wound site," said lead author Guillermo Ameer from the Northwestern University in Illinois, US.
The logic behind the regenerative bandage is laminin -- a protein found in most of the body's tissues including the skin.
Laminin sends signals to cells, encouraging them to differentiate, migrate and adhere to one another. The team identified a segment of laminin -- 12 amino acids in length -- called A5G81 that is critical for the wound-healing process.
They incorporated A5G81 into an antioxidant hydrogel bandage that it previously developed in the laboratory. The antioxidant nature also helps counters inflammation.
Hydrogel liquid can form the exact shape of the wound which makes this bandage better than others.
"Wounds have irregular shapes and depths. Our liquid can fill any shape and then stay in place. Other bandages are mostly based on collagen films or sponges that can move around and shift away from the wound site," Ameer said.
The team also used animal models to test the effectiveness and found no adverse effects of the bandage on the animals.
Ameer also added that their bandage can be rinsed off with cool saline, so the regenerating tissue remains undisturbed.
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Man dies after 'assault' following bar brawl in Alappuzha; five held
Alappuzha (PTI): A 30-year-old man died after being allegedly assaulted by a group following a brawl at a bar in Ezhupunna here, police said on Friday.
The deceased has been identified as Nidhin, a native of Kumbalangi in Ernakulam district.
Police said five persons have been taken into custody and are being interrogated at the Aroor police station.
According to the FIR, a brawl broke out between Nidhin and three persons at a bar in Ezhupunna on Thursday night.
After coming out of the bar, Nidhin, who was sitting on his motorcycle by the roadside, was allegedly manhandled and kicked by the accused, the FIR said.
He soon lost consciousness and collapsed on the road.
People noticing Nidhin lying on the roadside, rushed him to a hospital in Kumbalangi, where he was declared dead, police said.
A case of murder has been registered on Friday and further investigation is underway.
Police said detailed statements of those in custody are being recorded, after which their arrests will be formally registered.
The body will be handed over to relatives after the post-mortem examination.
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