Pregnancy history may be tied to Alzheimer's disease
Seoul, July 22 : Women, take note. Your history of pregnancy may affect the risk of Alzheimer's disease decades later, a new study has found.
The study, published in journal Neurology, found that women who give birth to five or more children may be more likely to develop Alzheimer's disease than women who have fewer births.
"Estrogen levels double by the eighth week of pregnancy before climbing to up to 40 times the normal peak level," said co-author Ki Woong Kim frrom the Seoul National University.
"If these results are confirmed in other populations, it is possible that these findings could lead to the development of hormone-based preventive strategies for Alzheimer's disease based on the hormonal changes in the first trimester of pregnancy," Kim added.
For the study, the researchers combined the data from two independent population-based studies with a total of 3,549 women.
Women -- who were an average age of about 71 at the start of the study -- provided information on their reproductive history. They took the diagnostic examination after an average of 46 years from their first childbirth.
During that time, the participants took tests of their memory and thinking skills to see whether they had developed Alzheimer's disease or its precursor, mild cognitive impairment.
The study found that a total of 118 women developed Alzheimer's disease and 896 women developed mild cognitive impairment.
The researchers also found that women who had given birth to five or more children were 70 per cent more likely to develop Alzheimer's disease than women who gave birth to fewer children.
Women who had experienced an incomplete pregnancy were about half as likely to develop Alzheimer's disease as women who had never had an incomplete pregnancy.
Of the 2,375 women who had an incomplete pregnancy, 47 developed Alzheimer's disease, compared to 71 of the 1,174 women who never had an incomplete pregnancy, they added.
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Another North Goa nightclub sealed; Kejriwal says corruption led to fire tragedy
Panaji (PTI): As part of a crackdown against tourist establishments violating laws and safety norms in the aftermath of the Arpora fire tragedy, Goa authorities on Saturday sealed a renowned club at Vagator and revoked the fire department NOC of another club.
Cafe CO2 Goa, located on a cliff overlooking the Arabian Sea at Vagator beach in North Goa, was sealed. The move came two days after Goya Club, also in Vagator, was shut down for alleged violations of rules.
Elsewhere, campaigning for local body polls, AAP leader Arvind Kejriwal said the fire incident at Birch by Romeo Lane nightclub at Arpora, which claimed 25 lives on December 6, happened because the BJP government in the state was corrupt.
An inspection of Cafe CO2 Goa by a state government-appointed team revealed that the establishment, with a seating capacity of 250, did not possess a no-objection certificate (NOC) of the Fire and Emergency Services Department. The club, which sits atop Ozrant Cliff, also did not have structural stability, the team found.
The Fire and Emergency Services on Saturday also revoked the NOC issued to Diaz Pool Club and Bar at Anjuna as the fire extinguishers installed in the establishment were found to be inadequate, said divisional fire officer Shripad Gawas.
A notice was issued to Nitin Wadhwa, the partner of the club, he said in the order.
Campaigning at Chimbel village near Panaji in support of his party's Zilla Panchayat election candidate, Aam Aadmi Party leader Kejriwal said the nightclub fire at Arpora happened because of the "corruption of the Pramod Sawant-led state government."
"Why this fire incident happened? I read in the newspapers that the nightclub had no occupancy certificate, no building licence, no excise licence, no construction licence or trade licence. The entire club was illegal but still it was going on," he said.
"How could it go on? Couldn't Pramod Sawant or anyone else see it? I was told that hafta (bribe) was being paid," the former Delhi chief minister said.
A person can not work without bribing officials in the coastal state, Kejriwal said, alleging that officers, MLAs and even ministers are accepting bribes.
