TB vaccine may help people with Type-1 diabetes
New York, June 24 : A vaccine primarily used for treating tuberculosis (TB) may be effective in reducing high blood sugar among people with Type - 1 diabetes, results from a clinical trial has revealed.
Type - 1 diabetes is a chronic condition in which the pancreas produce little or no insulin.
The findings showed that, three years after receiving two administrations of the Bacillus Calmette-Guerin (BCG) vaccine four weeks apart, people with longstanding Type-1 diabetes showed an improvement in HbA1c -- Aglycated haemoglobin -- measured to test the overall sugar levels to near normal levels.
"This is clinical validation of the potential to stably lower blood sugars to near normal levels with a safe vaccine, even in patients with longstanding disease," said Denise Faustman, director of the Massachusetts General Hospital Immunobiology Laboratory, US.
The study, published in the journal npj Vaccine, also reported that the effects of BCG vaccine on blood sugar control appear to depend on a totally novel metabolic mechanism that increases cellular consumption of glucose.
The team analysed data from 282 human study participants -- 52 with Type-1 diabetes who participated in the BCG clinical trials and 230 who contributed blood samples for mechanistic studies.
The results showed that the HbA1c levels of those receiving BCG had dropped by more than 10 per cent in three years after treatment and by more than 18 per cent in four years.
The study showed that BCG vaccination induces epigenetic reprogramming at the chromatin architecture level and functional alterations indicative of a permanent change in immunity.
Thus, the clinical effects and the proposed mechanism add to the emerging consensus that the BCG vaccine can have a lasting and valuable impact on the immune system, the researchers said.
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Punjab CM condemns attack on Sukhbir Badal, lauds cops for prompt action
Chandigarh (PTI): Punjab Chief Minister Bhagwant Mann strongly condemned the attack on Shiromani Akali Dal leader Sukhbir Singh Badal, who was fired at while performing 'sewa' outside the Golden Temple on Wednesday morning, and directed police to investigate the incident.
The chief minister also lauded the promptness of the Punjab Police in nabbing the attacker.
The man missed Badal as he was overpowered by police. The audacious attack was captured on cameras of media persons who had gathered outside the Sikh shrine to cover the second day of Badal's penance for "mistakes" committed by the SAD government in Punjab from 2007 to 2017.
"Punjab Police prevented a major incident from happening today. It is the result of the promptness of the Punjab Police that the conspiracy to defame Punjab and Punjabis has failed," Mann said in a post on X.
"The police achieved great success by arresting the assailant on the spot with their promptness... I strongly condemn the attack on Sukhbir Badal ji. I have issued strict instructions to the police to immediately investigate the incident and submit a report," he added.
Police identified the shooter as Narain Singh Chaura, a resident of Dera Baba Nanak. After the attack, he was whisked away by security officials.
Television footage showed the shooter slowly walking towards Badal, who was sitting in a wheelchair due to a fractured leg, and pulling out a gun from his pocket. A police official in plainclothes standing near Badal quickly intervened and grabbed the attacker's hands. In the melee, a bullet hit the wall behind Badal, who escaped unhurt.
