TB vaccine may help people with Type-1 diabetes
New York, June 24 : A vaccine primarily used for treating tuberculosis (TB) may be effective in reducing high blood sugar among people with Type - 1 diabetes, results from a clinical trial has revealed.
Type - 1 diabetes is a chronic condition in which the pancreas produce little or no insulin.
The findings showed that, three years after receiving two administrations of the Bacillus Calmette-Guerin (BCG) vaccine four weeks apart, people with longstanding Type-1 diabetes showed an improvement in HbA1c -- Aglycated haemoglobin -- measured to test the overall sugar levels to near normal levels.
"This is clinical validation of the potential to stably lower blood sugars to near normal levels with a safe vaccine, even in patients with longstanding disease," said Denise Faustman, director of the Massachusetts General Hospital Immunobiology Laboratory, US.
The study, published in the journal npj Vaccine, also reported that the effects of BCG vaccine on blood sugar control appear to depend on a totally novel metabolic mechanism that increases cellular consumption of glucose.
The team analysed data from 282 human study participants -- 52 with Type-1 diabetes who participated in the BCG clinical trials and 230 who contributed blood samples for mechanistic studies.
The results showed that the HbA1c levels of those receiving BCG had dropped by more than 10 per cent in three years after treatment and by more than 18 per cent in four years.
The study showed that BCG vaccination induces epigenetic reprogramming at the chromatin architecture level and functional alterations indicative of a permanent change in immunity.
Thus, the clinical effects and the proposed mechanism add to the emerging consensus that the BCG vaccine can have a lasting and valuable impact on the immune system, the researchers said.
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Dhyan Chand lifetime award to be replaced by Arjuna lifetime
New Delhi, Oct 24: The sports ministry on Thursday announced the discontinuation of the Dhyan Chand Award for lifetime achievement from this year onwards and the introduction of the Arjuna Award Lifetime in its place in a bid to "rationalise" the various sporting honours of the country.
Instituted in 2002, the Dhyan Chand Lifetime Award, named after hockey wizard Major Dhyan Chand, is given to individuals in disciplines that are part of the Olympic Games, Paralympic Games, Asian Games and Commonwealth Games, among others.
In 2023, the award was given to former shuttler Manjusha Kanwar, ex-hockey exponent Vineet Kumar and kabaddi player Kavitha Selvaraj.
"The various schemes for sports awards have been rationalised wherein Arjuna Award (Lifetime) has been introduced in place of Dhyan Chand Award. To recognise the efforts of coaches at grassroots/development level, they are now eligible for the Dronacharya Award," said a ministry statement.
"The Arjuna Award (Lifetime) has been introduced and will be given for life time contribution to sports development.
"Further, to recognize the Khelo India scheme, the Maulana Abdul Kalam Azad (MAKA) Trophy will be given to the University for Overall Top Performance in Khelo India University Games," it added.
The last date for applying for the national sports awards for 2024 is November 14.
