TB vaccine may help people with Type-1 diabetes
New York, June 24 : A vaccine primarily used for treating tuberculosis (TB) may be effective in reducing high blood sugar among people with Type - 1 diabetes, results from a clinical trial has revealed.
Type - 1 diabetes is a chronic condition in which the pancreas produce little or no insulin.
The findings showed that, three years after receiving two administrations of the Bacillus Calmette-Guerin (BCG) vaccine four weeks apart, people with longstanding Type-1 diabetes showed an improvement in HbA1c -- Aglycated haemoglobin -- measured to test the overall sugar levels to near normal levels.
"This is clinical validation of the potential to stably lower blood sugars to near normal levels with a safe vaccine, even in patients with longstanding disease," said Denise Faustman, director of the Massachusetts General Hospital Immunobiology Laboratory, US.
The study, published in the journal npj Vaccine, also reported that the effects of BCG vaccine on blood sugar control appear to depend on a totally novel metabolic mechanism that increases cellular consumption of glucose.
The team analysed data from 282 human study participants -- 52 with Type-1 diabetes who participated in the BCG clinical trials and 230 who contributed blood samples for mechanistic studies.
The results showed that the HbA1c levels of those receiving BCG had dropped by more than 10 per cent in three years after treatment and by more than 18 per cent in four years.
The study showed that BCG vaccination induces epigenetic reprogramming at the chromatin architecture level and functional alterations indicative of a permanent change in immunity.
Thus, the clinical effects and the proposed mechanism add to the emerging consensus that the BCG vaccine can have a lasting and valuable impact on the immune system, the researchers said.
Let the Truth be known. If you read VB and like VB, please be a VB Supporter and Help us deliver the Truth to one and all.
Lokayukta raids on Sarfaraz Khan unearth wealth worth Rs 14.38 crore including 38 acres land
Bengaluru (PTI): The Karnataka Lokayukta on Wednesday said cooperative societies director Sardar Sarfaraz Khan was found to be possessing assets to the tune of Rs 14.38 crore.
The Lokayukta sleuths had raided at 13 locations linked to Khan including "his residences, offices and the residences of his relatives," on December 24, 2025 in a Disproportionate Assets (DA) case, according to a release.
Khan is presently working as Secretary to the government in the Housing and Minority Welfare Department. He is close to the Housing and Minority Welfare Minister, B Z Zameer Ahmed Khan.
During the searches, the Lokayukta team found him owning four houses, 37 acres of agricultural land, which is estimated to be worth Rs 8.44 crore. The team found ornaments worth Rs 3 crore, Rs 1.64 crore worth vehicles, fixed deposits and other investments worth Rs 5.94 crore, the release added.
