New York, June 24 : A vaccine primarily used for treating tuberculosis (TB) may be effective in reducing high blood sugar among people with Type - 1 diabetes, results from a clinical trial has revealed.

Type - 1 diabetes is a chronic condition in which the pancreas produce little or no insulin.

The findings showed that, three years after receiving two administrations of the Bacillus Calmette-Guerin (BCG) vaccine four weeks apart, people with longstanding Type-1 diabetes showed an improvement in HbA1c -- Aglycated haemoglobin -- measured to test the overall sugar levels to near normal levels.

"This is clinical validation of the potential to stably lower blood sugars to near normal levels with a safe vaccine, even in patients with longstanding disease," said Denise Faustman, director of the Massachusetts General Hospital Immunobiology Laboratory, US.

The study, published in the journal npj Vaccine, also reported that the effects of BCG vaccine on blood sugar control appear to depend on a totally novel metabolic mechanism that increases cellular consumption of glucose.

The team analysed data from 282 human study participants -- 52 with Type-1 diabetes who participated in the BCG clinical trials and 230 who contributed blood samples for mechanistic studies.

The results showed that the HbA1c levels of those receiving BCG had dropped by more than 10 per cent in three years after treatment and by more than 18 per cent in four years.

The study showed that BCG vaccination induces epigenetic reprogramming at the chromatin architecture level and functional alterations indicative of a permanent change in immunity.

Thus, the clinical effects and the proposed mechanism add to the emerging consensus that the BCG vaccine can have a lasting and valuable impact on the immune system, the researchers said.

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Karwar: The District Disaster Management Authority (DDMA) of Uttara Kannada has issued a warning in light of heavy rainfall predicted by the Indian Meteorological Department and the Karnataka State Natural Disaster Management Centre. The coastal part of the state is expected to experience severe weather conditions over the next four days.

A Red Alert has been announced for today, July 14, 2024, and tomorrow, July 15, 2024

Precautionary Measures for the Public:

1. Avoid water bodies: The public and fishermen are advised to stay away from rivers, water bodies, and the sea.
2. Electrical hazards: Children and the public should avoid going near electric poles and stay clear of severed electric wires.
3. Structural safety: Avoid standing near or under trees, and stay away from fragile or old buildings.
4. Evacuation advisory: Residents in low-lying areas or those living in buildings at risk of collapsing due to the weather are advised to move to safe locations. Designated care centers identified by the concerned Tahsildar are available for shelter.

Emergency Contact:
In case of any emergency, residents are urged to contact the District Disaster Emergency Helpline at 1077 or 9483511015.

The DDMA stresses that these precautions must be followed diligently throughout the rainy season to ensure public safety.