TB vaccine may help people with Type-1 diabetes
New York, June 24 : A vaccine primarily used for treating tuberculosis (TB) may be effective in reducing high blood sugar among people with Type - 1 diabetes, results from a clinical trial has revealed.
Type - 1 diabetes is a chronic condition in which the pancreas produce little or no insulin.
The findings showed that, three years after receiving two administrations of the Bacillus Calmette-Guerin (BCG) vaccine four weeks apart, people with longstanding Type-1 diabetes showed an improvement in HbA1c -- Aglycated haemoglobin -- measured to test the overall sugar levels to near normal levels.
"This is clinical validation of the potential to stably lower blood sugars to near normal levels with a safe vaccine, even in patients with longstanding disease," said Denise Faustman, director of the Massachusetts General Hospital Immunobiology Laboratory, US.
The study, published in the journal npj Vaccine, also reported that the effects of BCG vaccine on blood sugar control appear to depend on a totally novel metabolic mechanism that increases cellular consumption of glucose.
The team analysed data from 282 human study participants -- 52 with Type-1 diabetes who participated in the BCG clinical trials and 230 who contributed blood samples for mechanistic studies.
The results showed that the HbA1c levels of those receiving BCG had dropped by more than 10 per cent in three years after treatment and by more than 18 per cent in four years.
The study showed that BCG vaccination induces epigenetic reprogramming at the chromatin architecture level and functional alterations indicative of a permanent change in immunity.
Thus, the clinical effects and the proposed mechanism add to the emerging consensus that the BCG vaccine can have a lasting and valuable impact on the immune system, the researchers said.
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UP CM Adityanath's plane makes emergency landing in Agra due to technical snag
Agra/Lucknow, Mar 26 (PTI): An aircraft carrying Uttar Pradesh Chief Minister Yogi Adityanath made an emergency landing at the Agra airport shortly after take off due to a technical snag, officials said.
The chief minister resumed his journey to Lucknow after over two hours, they said.
Adityanath was in Agra for a public event to mark the eighth anniversary of the BJP government in the state.
"After the programme, the chief minister was scheduled to leave from the Kheria Airport in Agra around 3.30 pm. The aircraft took off but returned shortly apparently due to a snag, which was then inspected by officials," a police official told PTI.
"The chief minister finally resumed his onward journey around 5.30 pm from Kheria," the official added.
Senior Agra district administration and police officials remained at the airport while the chief minister waited there. BJP supporters and local politicians were also present outside the airport.
Earlier in the day, Adityanath inaugurated and laid the foundation stone of 128 projects worth Rs 635.22 crore at 'Vikas Utsav' held in Agra to mark the completion of eight years of his government.
"Residents of Agra now have access to metro rail services, officially making Agra a metro city. The construction of the civil terminal at the airport is in its final stages," he said, adding that previous governments failed to provide these facilities.
