TB vaccine may help people with Type-1 diabetes
New York, June 24 : A vaccine primarily used for treating tuberculosis (TB) may be effective in reducing high blood sugar among people with Type - 1 diabetes, results from a clinical trial has revealed.
Type - 1 diabetes is a chronic condition in which the pancreas produce little or no insulin.
The findings showed that, three years after receiving two administrations of the Bacillus Calmette-Guerin (BCG) vaccine four weeks apart, people with longstanding Type-1 diabetes showed an improvement in HbA1c -- Aglycated haemoglobin -- measured to test the overall sugar levels to near normal levels.
"This is clinical validation of the potential to stably lower blood sugars to near normal levels with a safe vaccine, even in patients with longstanding disease," said Denise Faustman, director of the Massachusetts General Hospital Immunobiology Laboratory, US.
The study, published in the journal npj Vaccine, also reported that the effects of BCG vaccine on blood sugar control appear to depend on a totally novel metabolic mechanism that increases cellular consumption of glucose.
The team analysed data from 282 human study participants -- 52 with Type-1 diabetes who participated in the BCG clinical trials and 230 who contributed blood samples for mechanistic studies.
The results showed that the HbA1c levels of those receiving BCG had dropped by more than 10 per cent in three years after treatment and by more than 18 per cent in four years.
The study showed that BCG vaccination induces epigenetic reprogramming at the chromatin architecture level and functional alterations indicative of a permanent change in immunity.
Thus, the clinical effects and the proposed mechanism add to the emerging consensus that the BCG vaccine can have a lasting and valuable impact on the immune system, the researchers said.
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Delhi: Father, son held for killing 19-year-old woman in suspected honour killing
New Delhi (PTI): The Delhi Police has arrested a man and his son for allegedly murdering his 19-year-old daughter in west Delhi's Hari Nagar area, an official said on Friday.
The case first came to light on April 1 after a PCR call was received around 2 pm, alleging that a woman had been killed by her family members and her body was being taken for last rites, he said.
The accused, identified as Mohammad Maneer (55), a vegetable vendor, and his son Meraj Ali (19), were arrested in connection with the case, the officer said.
The victim had been in a relationship with a man from her native place for the past two years, which was opposed by her father, Maneer and brother Meraj, he said.
"When the girl did not end the relationship despite objections, the family killed her," the officer said.
On April 1, the police said that when their team reached the spot, they found that the woman's body was being taken for burial.
Acting on the input, the burial process was stopped over suspicion of honour killing.
"Police intercepted the family members and took possession of the body," he said.
Police said that the man who had made the PCR told them that the woman was in love with his cousin.
During the inquiry, police also interacted with the PCR caller, who said his cousin, a friend of the deceased, had informed him about the situation and suspected foul play, prompting him to alert the police control room.
The body of the woman was subsequently shifted to the mortuary of Deen Dayal Upadhyay Hospital for preservation and postmortem.
Police said that both the crime team and the forensic science laboratory (FSL) team were called to inspect the scene and collect evidence.
Police said that, as per the postmortem report, the cause of death was identified as smothering, indicating that the woman was suffocated.
A preliminary inquiry also revealed that the family had initiated preparations for the last rites soon after the woman's death, raising suspicion about the circumstances.
Initial investigation pointed to the family's opposition to the woman's relationship.
"The family members of the woman saw her with the man, and she was taken back home. We got to know that she was beaten up and even locked inside the house for some days," a source said.
Further investigation into the matter is underway, police added.
