Vaccinated pregnant women pass high level of antibodies to babies: Study
Washington(PTI): Women who receive the mRNA COVID-19 vaccine during pregnancy pass high levels of antibodies to their babies, according to a study.
The effectiveness of COVID-19 vaccines lies in their ability to trigger the production of the right antibodies, blood proteins capable of protecting individuals from infection, researchers said.
Whether this protection could pass from mothers to their infants before birth had remained a question, they said.
The study, published in the American Journal of Obstetrics & Gynecology Maternal-Fetal Medicine on Wednesday, was conducted on 36 newborns whose mothers received either the Pfizer or Moderna COVID-19 vaccine during pregnancy.
The research team led by NYU Grossman School of Medicine in the US found that 100 per cent of the infants had protective antibodies at birth.
Antibodies can either be produced as part of the natural response to infection or triggered by vaccines.
Though the sample size is small, "it is encouraging that neonatal antibody levels are high if women are vaccinated," said Jennifer L Lighter, an associate professor at Hassenfeld Children's Hospital at NYU Langone, and the study's senior author.
The team was able to tell apart antibodies in the neonatal blood that were created in response to natural infection from those made in response to the vaccines.
The researchers noted that the result is relevant because natural antibody responses against the SARS-CoV-2 virus, that causes COVID-19, are not sufficiently protective for many people.
Recent data from the US Centers for Disease Control and Prevention (CDC) suggests that just 23 per cent of pregnant women have been vaccinated, despite growing evidence of prenatal vaccine safety.
The researchers observed the highest levels of antibodies in cord blood of mothers who were fully vaccinated during the second half of their pregnancies.
This insight provides evidence of transferred immunity to neonates, which correlates to protection against infection for infants during the first months of life, they said.
"Studies continue to reinforce the importance of vaccines during pregnancy and their power to protect two lives at once by preventing severe illness in both mothers and babies," said Ashley S Roman, Professor at NYU Langone Health, and one of the study's principal investigators.
"If babies could be born with antibodies, it could protect them in the first several months of their lives, when they are most vulnerable, Roman said.
Roman and colleagues confirmed the strong evidence that the mRNA vaccines are safe during pregnancy in a study published on August 16 in the same journal.
That study found no increased risks during pregnancy, birth complications, or identifiable risks to the fetus among those who received the vaccine.
Existing studies analyse antibodies to the spike protein (anti-S IgG) alone, which may be present after natural infection or vaccination, and do not include antibodies to the nucleocapsid protein (anti-N IgG), which is only present following natural infection.
Among the 36 samples collected, all had high levels of anti-S IgG. Of those samples, 31 were tested for anti-N IgG and were negative.
"High levels of transplacental antibody transfer are not surprising. It is consistent with what we see with other immunizations," Lighter said.
"Our findings add to a growing list of important reasons why women should be advised to receive the COVID-19 vaccine during pregnancy for the added benefit of their newborn receiving crucial protection," he said.
The researchers emphasised that more study is needed to determine how effective the infant antibodies are, how long protection will last, and if vaccination in the second half of pregnancy may confer higher levels of antibody transfer than vaccination earlier in pregnancy.
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Russian President Putin says India, Russia collaboration not directed against anyone
New Delhi (PTI): The India-Russia collaboration is not directed against any country and it is solely aimed at safeguarding the national interests of the two sides, Russian President Vladimir Putin has said against the backdrop of Washington's aggressive approach towards New Delhi and Moscow.
In the context of India's energy ties with Russia, Putin said certain "actors" dislike New Delhi's growing role in international markets in view of its close relations with Moscow and these elements are aiming to constrain India's influence for political reasons by imposing "artificial obstacles".
In an interview to India Today news channel that was released on Thursday evening, the Russian president, referring to Western sanctions against Moscow, said his country's energy cooperation with New Delhi largely "remains unaffected".
Putin landed in New Delhi this evening on a two-day visit to hold summit talks with Prime Minister Narendra Modi.
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His trip comes at a time India-US relations are going through possibly the worst phase in the last two decades after Washington imposed a whopping 50 per cent tariff on Indian goods, including 25 per cent levies for New Delhi's procurement of Russian crude oil.
"Neither me nor Prime Minister Modi, despite certain external pressure we face, have never approached our collaboration to work against someone," the Russian president said in response to a question on Washington's aggressive approach.
"President Trump has his own agenda, his own goals, whereas we focus on ours -- not against anyone, but rather aimed at safeguarding our respective interests, India's and Russia's interests," he said.
Rejecting Washington's objection to India procuring crude oil from Russia, Putin said if the US has the right to buy Russian fuel, why "shouldn't India have the same privilege".
"As for India's purchase of energy resources from Russia, I would like to note and have already mentioned this once, the US itself still buys nuclear fuel from us for its own nuclear power plants," Putin said.
The Russian president also responded to a question on India lowering procurement of crude oil from Russia in view of Western sanctions on Moscow.
ALSO READ: Russian president Putin arrives in Delhi on 2-day visit
"Well, there is a certain decline in overall trade turnover during the first nine months of this year. This is just a minor adjustment. Overall, our trade turnover stands almost at the same level as before," he said.
"I can't give you exact monthly figures right now, but trade in petroleum products and crude oil, as well as the production of petroleum products for consumers of oil, Russian oil, is running smoothly in India," he said.
Putin also said that India cannot be treated the way it was several decades back.
"Prime Minister Modi is not someone who succumbs to pressure easily. The Indian people can certainly take pride in their leader. This is absolutely obvious," he said.
"His stance is unwavering and straightforward, without being confrontational. Our goal is not to provoke conflict; rather, we aim to protect our lawful rights. India does the same," he said.
On the Ukraine conflict, Putin said he believed the US is actively seeking a solution to this problem. "I am absolutely certain, with no doubt at all, he (Trump) sincerely aims for a peaceful resolution."
Putin said Trump genuinely wants to end the hostilities and prevent further loss of lives. "But there could also be political interests tied to ending the confrontation between Russia and Ukraine, or economic motives too."
On bilateral trade, Putin said over 90 per cent of "our transactions are already conducted in national currencies".
"While some complications arise due to the presence of numerous intermediaries, there are also solutions," he said.
The Russian president also complimented PM Modi's leadership.
"Our collaborative endeavours with Prime Minister Modi carry significant weight because they transcend our mutual ties," he said.
"Given its direct relevance to both nations, ensuring stability in key areas of engagement is crucial, as it helps secure the fulfilment of our objectives. Prime Minister Modi sets very challenging tasks for the country --and for himself in the first place, then for the administration, and eventually for the nation," he said.
The Russian president did not give a direct reply to a question on if India was looking at procuring additional batches of S-400 missile systems.
"India stands out as one of our reliable and privileged partners in this area. We are not merely selling something to India and India isn't merely buying something from us in the sphere of defence and security.
"It is a different level, a different quality of relations we have with India, and we value this. We see how India values this relationship too," he said.
Putin said Russia is not simply selling defence technology to India but it is sharing it with the country.
"It is a very rare thing to see in the sphere of military-technical cooperation. It speaks to the level of trust between the two countries and the level of trust between the two peoples.
"We have a broad portfolio indeed, including naval construction, rocket and missile engineering, and aircraft engineering," he added.
