Matthew Perry died from effects of drug ketamine, coroner says
LOS ANGELES (AP/PTI): Matthew Perry died from the acute effects of the anesthetic ketamine, according to the results of an autopsy on the 54-year-old “Friends” actor released Friday.
The Los Angeles County Department of Medical Examiner said in the autopsy report that Perry also drowned in “the heated end of his pool,” but that it was a secondary factor in his Oct. 28 death, deemed an accident.
People close to Perry told investigators that he was undergoing ketamine infusion therapy, an experimental treatment used to treat depression and anxiety. But the medical examiner said the levels of ketamine in Perry’s body were in the range used for general anesthesia during surgery, and that his last treatment 1 1/2 weeks earlier wouldn’t explain those levels. The drug is typically metabolized in a matter of hours.
The report says coronary artery disease and buprenorphine, which is used to treat opioid use disorder, also contributed.
The amount of ketamine detected “would be enough to make him lose consciousness and lose his posture and his ability to keep himself above the water,” said Dr. Andrew Stolbach, a medical toxicologist with Johns Hopkins Medicine who reviewed the autopsy report at the request of The Associated Press.
“Using sedative drugs in a pool or hot tub, especially when you’re alone, is extremely risky and, sadly, here it’s fatal,” said Stolbach, who noted that both ketamine and buprenorphine can be used safely.
Perry was declared dead after being found unresponsive at his home in the Pacific Palisades area of Los Angeles. Investigators performed the autopsy the following day.
The actor had taken drugs in the past but had been “reportedly clean for 19 months,” according to the report.
Perry had played pickleball earlier in the day, the report says, and his assistant, who lives with him, found him face down in the pool after returning from errands.
The assistant told investigators Perry had not been sick, had not made any health complaints, and had not shown evidence of recent alcohol or drug use.
Postmortem blood tests showed “high levels” of ketamine in his system, which could have raised his blood pressure and heart rate and dulled his impulse to breathe.
Buprenorphine, commonly used in opioid addiction and found in therapeutic levels in Perry’s blood, could have contributed to the breathing problem, the autopsy said. It would have been risky to mix the central nervous system depressant with ketamine “due to the additive respiratory effects when present with high levels of ketamine,” according to the autopsy report.
The report said his coronary artery disease would have made him more susceptible to the drugs’ effects.
Perry was among the biggest television stars of his generation when he played Chandler Bing alongside Jennifer Aniston, Courteney Cox, Lisa Kudrow, Matt LeBlanc and David Schwimmer for 10 seasons from 1994 to 2004 on NBC’s megahit sitcom “Friends.”
His castmates, like many of his friends, family and fans, were stunned by his death, and paid him loving tribute in the weeks that followed.
Perry was open about discussing his struggles with addiction dating back to his time on “Friends.”
“I loved everything about the show but I was struggling with my addictions which only added to my sense of shame,” he wrote in his 2022 memoir. “I had a secret and no one could know.”
A woman whose name is redacted in the autopsy report told investigators that Perry had been in good spirits when she spoke to him a few days earlier, but had been taking testosterone shots which she said were making him “angry and mean.” She said he had quit smoking two weeks earlier.
The woman said he had been receiving the ketamine infusions for his mental health, and that his doctor had been giving them to him less often because he had been feeling well.
Ketamine is a powerful anesthetic approved by U.S. health regulators for use during surgery, but in the past decade it has emerged as an experimental treatment for a range of psychiatric and hard-to-treat conditions, including depression, anxiety and chronic pain.
While not approved by regulators, doctors are free to prescribe drugs for these alternate uses if they think their patients could benefit, and hundreds of clinics across the U.S. offer ketamine infusions and other formulations for various health conditions.
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RJD surprise element in J’khand polls, party candidates leading in 5 of 6 assembly seats
Ranchi(PTI): The Rashtriya Janata Dal (RJD) has emerged as a surprise element in the Jharkhand assembly elections with its candidates leading in five of the six seats where the party is contesting, according to trends available on the Election Commission's website on Saturday.
RJD candidates in five assembly seats were leading over sitting BJP legislators.
In 2019, RJD had secured only the Chatra seat where its nominee Satyanand Bhokta won.
In Deoghar, RJD’s Suresh Paswan was leading by 19,581 votes over his nearest rival and BJP's sitting MLA Narayan Das after the third round of counting.
RJD’s Sanjay Prasad Yadav was ahead by 19,867 votes in Godda over BJP MLA Amit Kumar Mandal after the sixth round of counting.
In Koderma, RJD nominee Subhash Prasad Yadav, who was out on bail, was leading by a margin of 3,471 votes over BJP’s sitting legislator Neera Yadav.
Subhas Prasad Yadav, considered to be one of the close aides of RJD supremo Lalu Prasad, was recently granted bail by the Supreme Court in a money laundering case.
Party’s Naresh Prasad Singh was leading by 5,159 votes after the fourth round of counting over BJP’s Bishrampur MLA Ramchandra Chandravanshi.
RJD's Sanjay Kumar Singh Yadav was also leading from Hussainabad by 8,213 votes after the fourth round of counting over BJP MLA Kamlesh Kumar Singh.
Party’s candidate Rashmi Prakash, however, was trailing from Chatra by 3,776 votes.
Bhokta did not contest the elections this time, and his daughter-in-law Prakash was given a ticket.
