Coffee adversely impacts Alzheimer patients.
London, April 4: Regular intake of coffee or caffeine by patients with Alzheimer's disease may deteriorate their neuropsychiatric symptoms, including but not limited to anxiety, say researchers.
While it is well known that memory problems are the hallmarks of Alzheimer's disease, this dementia is also characterized by neuropsychiatric symptoms such as anxiety, apathy, depression, hallucinations, paranoid, sundowning and more known as Behavioral and Psychological Symptoms of Dementia (BPSD) which may be strongly present already in the first stages of the disorder.
The results indicate that caffeine worsened these symptoms in mice with Alzheimer's.
The researchers also discovered significant effects, especially in relation to neophobia -- a fear of everything new -- anxiety-related behaviours, and emotional and cognitive flexibility.
"The mice develop Alzheimer's disease in a very close manner to the human patients with early-onset form of the disease," said lead author Raquel Baeta-Corral from the Autonomous University of Barcelona in Spain.
"They not only exhibit the typical cognitive problems but also a number of Behavioural and Psychological Symptoms of Dementia (BPSD)-like symptoms, so it is a valuable model to address whether the benefits of caffeine will be able to compensate its putative negative effects."
For the study, the team analyzed the effect of caffeine on normal ageing mice and familial Alzheimer’s models.
However, coffee has also been suggested as a strategy to prevent dementia, both in patients with Alzheimer's disease and in normal ageing processes, due to its action in blocking molecules - adenosine receptors - which may cause dysfunctions and diseases in old age.
But "our observations of adverse caffeine effects in an Alzheimer's disease model together with previous clinical observations suggest that an exacerbation of BPSD-like symptoms may partly interfere with the beneficial cognitive effects of caffeine", the researchers said.
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Strict security measures in place in Mumbai for Messi's events at 2 venues Dec 14, say police
Mumbai (PTI): In view of Argentine superstar footballer Lionel Messi's visit to Mumbai on Sunday, the city police are implementing stringent security measures, like not allowing water bottles, metals, coins inside the stadiums and setting up watchtowers to keep an eye on the crowd, officials said.
The police also said taking extra care to avoid any stampede-like situation and to prevent recurrence of the chaotic situation that unfolded in Kolkata during Messi's visit on Saturday as thousands of fans protested inside the Salt Lake stadium here after failing to catch a clear glimpse of the football icon despite paying hefty sums for tickets.
Messi is expected to be present at the Cricket Club of India (Brabourne Stadium) in Mumbai on Sunday for a Padel GOAT Cup event followed by attending a celebrity football match. He is expected to proceed to the Wankhede Stadium for the GOAT India Tour main event around 5 pm.
"In view of Lionel Messi's visit to Mumbai, the police are geared up and have put in place a high level of security arrangements in and around the stadiums located in south Mumbai. Considering the chaos that prevailed in Kolkata and the security breach, we have deployed World Cup-level security arrangements at Brabourne and Wankhede stadiums," an official said.
Expecting heavy crowd near the stadiums during Messi's visit, the city police force has deployed more than 2,000 of its personnel near and around both the venues, he said.
As the Mumbai police have the experience of security 'bandobast' during the victory parade of ICC World Cup-winning Indian team and World Cup final match at the Wankhede Stadium, in which over one lakh cricket fans had gathered, we are prepared to handle a large crowd of fans, he said.
"We are trying to avoid the errors that occurred in the past," the official said.
There is no place to sneak inside the stadiums in Mumbai like the Kolkata stadium, according to him.
The police are also asking the organisers to provide all the required facilities to the fans inside the stadium, so that there will be no chaos, he said, adding the spectators have purchased tickets in the range of Rs 5,000 to 25,000. After paying so much of amount, any spectator expects proper services, while enjoying the event, he said.
The police are expecting 33,000 spectators at the Wankhede Stadium and over 4,000 at Brabourne Stadium. Besides this, more than 30,000 people are expected outside and around the stadiums just to have a glimpse of the football sensation, he said.
The organisers responsible for Messi's India visit recently came to Mumbai to discuss security arrangements. During the meeting, the Mumbai police asked them not to take the event lightly, according to the official.
After those requirements were fulfilled, the final security deployment was chalked out, he said.
Police has the standard procedure of the security arrangements inside the Wankhede Stadium, where people are barred from taking water bottles, metals objects, coins. Police are setting up watch towers near the stadiums and there will be traffic diversions, so that there is maximum space available to stand, according to the official.
Police are also appealing to the spectators to use public transport service for commuting and avoid personal vehicles to reach south Mumbai.
To avoid any stampede-like situation, police are also taking precautionary measures and will stop the fans some distance ahead of the stadium and public announcement systems will be used to guide the crowd. Barricades will be placed at various places to manage the crowd.
In case the crowd swells up beyond expectation, the police will divert people to other grounds and preparations in this regard underway, he said.
Additional police force has been deployed in south Mumbai to tackle any kind of situation, he said.
