New York, May 18: Researchers have found that long term chronic isolation cause the build-up of a chemical in the brain, that increases stress, aggression and fear.

The mice isolated for two weeks showed behavioural changes like, increased aggressiveness towards unfamiliar mice, persistent fear, and hypersensitivity to threatening stimuli.

When encountering a threatening stimulus, mice that have been socially isolated remain frozen in place long after the threat has passed, whereas normal mice stop freezing soon after the threat is removed, the research said. 

Although the study was done in mice, it has potential implications for understanding how chronic stress affects humans and has potential applications for treating mental health disorders, said lead author Moriel Zelikowsky, postdoctoral scholar at the California Institute of Technology in the US.

Previous studies have determined that social isolation for two weeks in mice resulted in the upregulation of the signalling molecule neuropeptide, tachykinin 2 (Tac2)/neurokinin B (NkB) -- a short protein molecule. 

In the new study, published in the journal Cell, the team found that chronic isolation leads to an increase in Tac2 gene expression and the production of a neuropeptide called neurokinin B (NkB) throughout the brain. 

But, administration of a drug that chemically blocks NkB-specific receptors enabled the stressed mice to behave normally, eliminating the negative effects of social isolation. 

On the other hand, artificially increasing Tac2 levels and activating the corresponding neurons in normal, animals led them to behave like isolated and stressed, the research showed.

Suppressing the Tac2 gene in certain different brain parts, increased fear behaviours, or aggression accordingly, implying that it must increase in different brain regions to produce the various effects of social isolation, the researchers said.

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London, Nov 22: A bomb disposal squad deployed as a “precaution” to the South Terminal of Gatwick Airport concluded an investigation into a "security incident" on Friday after making a “suspect package” safe.

The South Terminal of Gatwick Airport, the UK's second busiest airport after Heathrow, which was briefly shut owing to the incident reopened following the incident.

The Gatwick is around 45 km south of London.

Two people detained during the enquiries have since been allowed to continue their journey as the airport was opened.

“Police have concluded their investigation into a report of a suspect package at Gatwick Airport. Officers from the EOD (Explosive Ordnance Disposal) team made the package safe, and the airport has been handed back to its operator,” Sussex Police said in an updated statement.

“Two people detained while enquiries were ongoing have subsequently been allowed to continue their journeys. There will remain an increased police presence in the area to assist with passengers accessing the South Terminal for onward travel,” the statement added.

Earlier on Friday, the incident caused severe disruption at the busy airport’s South Terminal, while the North Terminal of Gatwick Airport remained unaffected.

“Police were called to the South Terminal at Gatwick Airport at 8.20 am on Friday (November 22) following the discovery of a suspected prohibited item in luggage,” a Sussex Police statement said.

“To ensure the safety of the public, staff and other airport users, a security cordon has been put in place whilst the matter is dealt with. As a precaution, an EOD (Explosive Ordnance Disposal) team is being deployed to the airport. This is causing significant disruption and some roads around the South Terminal have been closed. We’d advise the public to avoid the area where possible,” it said.

Footage on social media taken outside the airport showed crowds of frustrated travellers being moved away from the terminal building.

Gatwick said it was working hard to resolve the issue.

“A large part of the South Terminal has been evacuated as a precaution while we continue to investigate a security incident," the airport said in a social media post.

“Passengers will not be able to enter the South Terminal while this is ongoing. The safety and security of our passengers and staff remain our top priority. We are working hard to resolve the issue as quickly as possible.”

Train and bus services that serve the airport were also impacted while the police carried out their inquiries.

In an unrelated incident in south London on Friday morning, the US Embassy area in Nine Elms by the River Thames was the scene of a controlled explosion by Scotland Yard dealing with what they believe may have been a “hoax device”.

“We can confirm the 'loud bang' reported in the area a short time ago was a controlled explosion carried out by officers,” the Metropolitan Police said in a post on X.

“Initial indications are that the item was a hoax device. An investigation will now follow. Some cordons will remain in place for the time being but the majority of the police response will now be stood down,” it added.