How social isolation may increase stress
New York, May 18: Researchers have found that long term chronic isolation cause the build-up of a chemical in the brain, that increases stress, aggression and fear.
The mice isolated for two weeks showed behavioural changes like, increased aggressiveness towards unfamiliar mice, persistent fear, and hypersensitivity to threatening stimuli.
When encountering a threatening stimulus, mice that have been socially isolated remain frozen in place long after the threat has passed, whereas normal mice stop freezing soon after the threat is removed, the research said.
Although the study was done in mice, it has potential implications for understanding how chronic stress affects humans and has potential applications for treating mental health disorders, said lead author Moriel Zelikowsky, postdoctoral scholar at the California Institute of Technology in the US.
Previous studies have determined that social isolation for two weeks in mice resulted in the upregulation of the signalling molecule neuropeptide, tachykinin 2 (Tac2)/neurokinin B (NkB) -- a short protein molecule.
In the new study, published in the journal Cell, the team found that chronic isolation leads to an increase in Tac2 gene expression and the production of a neuropeptide called neurokinin B (NkB) throughout the brain.
But, administration of a drug that chemically blocks NkB-specific receptors enabled the stressed mice to behave normally, eliminating the negative effects of social isolation.
On the other hand, artificially increasing Tac2 levels and activating the corresponding neurons in normal, animals led them to behave like isolated and stressed, the research showed.
Suppressing the Tac2 gene in certain different brain parts, increased fear behaviours, or aggression accordingly, implying that it must increase in different brain regions to produce the various effects of social isolation, the researchers said.
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South zone finalists announced at WAVES VFX challenge in Bengaluru
Bengaluru: The South Zone round of the WAVES VFX Challenge took place today in Bengaluru, organized by the Association of Bangalore Animation Industry (ABAI).
The day-long competition brought together talented participants from across southern India, with the goal of selecting top finalists who will go on to represent the region at the national finals next month during the WAVES Summit in Mumbai.
Finalists were selected in three categories:
Student Category
Winner: Soumya Das
Runner-up: Gagan HP
Professional Category
Winner: Mohamad Javeed
Runner-up: S Sai Chandan
Enthusiasts Category
Winner: Gagan Ajai
Over 1,500 entries were received from students, working professionals, and VFX enthusiasts, all centered around the theme “Super Hero Power.” Out of these, 14 entries were shortlisted to compete in today’s final round. One winner and one runner-up from each category were chosen to represent the South Zone in Mumbai.
ABAI Secretary R.K. Chand appreciated the strong participation and encouraged industry professionals to attend the Mumbai summit, which will host well-known personalities from films, advertising, and creative sectors. He also mentioned that the WAVES Challenge was recently launched in Bengaluru by Sanjay Jaju, Secretary, Ministry of Information and Broadcasting.
The event was inaugurated by Dr. Sagar Gulati, Director of the School of Creative Design and Information Technology at Jain (Deemed-to-be University), the zonal partner for the competition.
The day also featured two special sessions led by industry experts. Vijay Selvam from the global VFX studio MPC held a masterclass titled “Concept Reality,” where he discussed lighting, animation, compositing, and photorealistic effects. Students got the chance to interact with him during a Q&A session.
Another session was conducted by Rakesh H, Lead Head at The Mill, who spoke about how visual effects are used in advertising. Nearly 100 students attended these sessions, gaining valuable industry insights and learning opportunities.
