Increased risk of serious blood clots up to six months after COVID-19: Study
London, Apr 7: People infected with SARS-CoV-2, the virus that causes COVID-19, have an increased risk of developing serious blood clots for up to six months after the infection, even in mild cases, according to a study published in The BMJ.
The researchers found an increased risk of deep vein thrombosis -- a blood clot in the leg -- up to three months after COVID-19 infection, pulmonary embolism -- a blood clot in the lung -- up to six months, and a bleeding event up to two months.
They also show a higher risk of events in patients with underlying conditions, patients with more severe COVID-19, and during the first pandemic wave compared with the second and third waves.
The researchers from Umea University in Sweden noted that these results support measures to prevent thrombotic events, especially for high risk patients, and strengthen the importance of vaccination against COVID-19.
Using national registries in Sweden, they identified more than one million people with confirmed SARSCoV-2 infection between February 1, 2020 and May 25, 2021, matched by age, sex, and county of residence to more than four million people who had not had a positive SARS-CoV-2 test result.
The researchers first calculated the rates of deep vein thrombosis, pulmonary embolism, and bleeding in COVID-19 individuals during a control period -- before and long after COVID-19 diagnosis -- and compared it to the rates in different time intervals after COVID-19 diagnosis.
They then calculated the rates of deep vein thrombosis, pulmonary embolism, and bleeding 1-30 days after COVID-19 diagnosis in the COVID-19 group and compared them to the corresponding rates in the control group.
The results show that compared with the control period, risks were significantly increased 90 days after COVID-19 for deep vein thrombosis, 180 days for pulmonary embolism, and 60 days for bleeding.
After taking account of a range of potentially influential factors, the researchers found a five-fold increase in risk of deep vein thrombosis, a 33-fold increase in risk of pulmonary embolism, and an almost twofold increase in risk of bleeding in the 30 days after infection.
This means that a first deep vein thrombosis occurred in 401 patients with COVID-19 and 267 control patients, the researchers said.
A first pulmonary embolism event occurred in 1,761 patients with COVID-19 and 171 control patients, and a first bleeding event occurred in 1,002 patients with covid-19 and 1,292 control patients, they said.
The researchers found that the risks were highest in patients with more severe COVID-19 and during the first pandemic wave compared with the second and third waves, which they said could be explained by improvements in treatment and vaccine coverage in older patients after the first wave.
Even among mild, non-hospitalised COVID-19 patients, the researchers found increased risks of deep vein thrombosis and pulmonary embolism.
No increased risk of bleeding was found in mild cases, but a noticeable increase was observed in more severe cases.
This is an observational study, so the researchers cannot establish cause, and they acknowledge several limitations which might have affected their findings.
For example, they said VTE may have been underdiagnosed in patients with COVID-19, testing for the disease was limited, especially during the first pandemic wave, and information on vaccination was not available.
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Women BJP MLAs protest against opposition in UP assembly premises
Lucknow (PTI): Women BJP MLAs held a protest in the Vidhan Bhawan complex before the one-day special session of Uttar Pradesh assembly, slamming the opposition for defeating the passage of a bill, which would have led to implementation of the Women's Reservation Law, in the Lok Sabha.
This followed another demonstration by Samajwadi Party MLAs, who alleged that the BJP was misleading public in the name of women's reservation.
The women BJP legislators assembled in front of Chaudhary Charan Singh's statue in the assembly premises, holding banners inscribed with the slogan "Insult to Matrushakti (women's power), India will not tolerate it". The protesting members entered the main hall of Vidhan Bhawan carrying the banners.
Participating in the protest, the state Minister for Women Welfare and Child Development, Baby Rani Maurya, told reporters that all opposition parties, including the Samajwadi Party and the Congress, had opposed the women's reservation, a stance for which they would have to pay a heavy political price.
"On this issue, all of us women stand united. We will ensure that we secure our reservation," she said.
BJP MLA Ketki Singh remarked that their protest represents the collective outrage of millions of women across the state.
Singh asserted that the opposition has betrayed women by creating hurdles in the path of women's reservation. The current demonstration is merely the beginning, and very soon, women from every street, intersection and household will join the protest movement, she said.
Minister Vijaylakshmi Gautam said, "We strongly condemn the despicable act committed by the Samajwadi Party and the Congress in an attempt to hold back 'half the population' (women). Their action was directed against the very bill that Prime Minister Narendra Modi had introduced to empower and strengthen Nari Shakti (women's power), and which he strived to pass expeditiously."
Uttar Pradesh assembly is holding a one-day special session on Thursday. During the session, the government is set to move a censure motion against the opposition parties over their failure to pass the Constitution Amendment Bill, which would have led to implementation of the Women's Reservation Act, in the Lok Sabha.
