Lancet study says long Covid has more than 200 symptoms
London, Jul 15: Patients who experience long Covid can report more than 200 symptoms across 10 organ systems, according to a study published in the Lancet’s journal EClinicalMedicine on Thursday.
The study, led by University College London (UCL) scientists together with a patient-led research collaborative, found the most common symptoms of long-term COVID effects as fatigue, post-exertional malaise (the worsening of symptoms after physical or mental exertion), and cognitive dysfunction, often called brain fog.
Of the diverse range of symptoms, others included: visual hallucinations, tremors, itchy skin, changes to the menstrual cycle, sexual dysfunction, heart palpitations, bladder control issues, shingles, memory loss, blurred vision, diarrhoea, and tinnitus.
While there has been a lot of public discussion around long COVID, there are few systematic studies investigating this population; hence relatively little is known about its range of symptoms, and their progression over time, the severity, and expected clinical course (longevity), its impact on daily functioning, and expected return to baseline health, said Dr Athena Akrami, neuroscientist at the Sainsbury Wellcome Centre at UCL and senior of the study published in the Lancet's EClinicalMedicine'.
In this unique approach, we have gone directly to long haulers' around the world in order to establish a foundation of evidence for medical investigation, improvement of care, and advocacy for the long COVID population. This is the most comprehensive characterisation of long COVID symptoms, so far, she said.
For the study, patient researchers connected through the Body Politic online COVID-19 support group and created a web-based survey designed to characterise the symptom profile and time course in patients with confirmed or suspected long COVID, along with the impact on daily life, work, and return to health.
With responses from 3,762 eligible participants from 56 countries, the researchers identified a total of 203 symptoms in 10 organ systems; of these, 66 symptoms were tracked for seven months.
The research team, who have all had or continue to have long COVID, are now calling for clinical guidelines on assessing long COVID to be significantly widened beyond currently advised cardiovascular and respiratory function tests to include neuropsychiatric, neurological, and activity intolerance symptoms.
The authors also advocate that a national screening programme, accessible to anyone who thinks they have long COVID, should be undertaken.
Given the heterogeneous and diverse make-up of symptoms that affect multiple organ systems, it is only by detecting the root cause that patients will receive the correct treatment, they note.
Dr Akrami added: For the first time this study shines a light on the vast spectrum of symptoms, particularly neurological, prevalent and persistent in patients with long COVID.
Memory and cognitive dysfunction, experienced by over 85 per cent of respondents, were the most pervasive and persisting neurologic symptoms, equally common across all ages, and with substantial impact on work. Headaches, insomnia, vertigo, neuralgia, neuropsychiatric changes, tremors, sensitivity to noise and light, hallucinations (olfactory and other), tinnitus, and other sensorimotor symptoms were also all common, and may point to larger neurological issues involving both the central and peripheral nervous system.
The survey was open to those aged 18 or over who had experienced symptoms consistent with COVID-19, including those with and without a positive SARS-CoV-2 test. It consisted of 257 questions.
In order to characterise long COVID symptoms over an extended duration, analysis of survey data was limited to respondents with illnesses lasting longer than 28 days and whose onset of symptoms occurred between December 2019 and May 2020, allowing analysis of symptoms from week one to month seven.
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Several Gurugram schools receive hoax bomb threats
Gurugram (PTI): Several Gurugram schools received another hoax bomb threat emails on Wednesday morning, prompting police to launch searches on the premises.
Police said the email was sent by the 'Khalistan National Army', with threats issued to Haryana Chief Minister Nayab Singh Saini to declare April 29 as the "40th Khalistan Declaration Day". It also threatened to bomb the Red Fort in Delhi.
Police said it was a hoax as no suspicious items were found after an intensive search.
Several schools, including Shri Ram, Amity, and the HDFC school, received threatening emails at 8.33 am, when classes had already begun, police said.
The school administrations became aware of the threats around 9 am and immediately informed the police, a senior police officer said.
The schools immediately implemented emergency protocols, with many declaring a holiday and asking parents to take their children home safely, the officer said.
A large number of anxious parents gathered outside the schools, as police and bomb squad teams reached the spots and started checks.
"Around 10 schools have approached the police from morning until now over bomb threats. Police teams are alert, and searches are underway on all the premises", the officer said.
As soon as the information about this email was received, police in Gurugram and Delhi swung into action and started investigation.
Schools immediately implemented emergency protocols upon receiving the mail. Many schools declared a holiday and sent messages to parents, asking them to take their children home. Large crowds of parents gathered outside the schools.
The schools were sanitised by sending a bomb disposal squad as well as a dog squad.
A senior police officer said that police teams thoroughly searched the school premises, classrooms, buildings, and surrounding areas. No suspicious objects or explosive materials were found during the investigation.
"Police teams are seriously investigating the entire matter. Cyber experts are being consulted to determine the authenticity of the email, its source, and the identity of the sender", added the officer.
This is the third time since January that schools have received fake bomb threats.
In March, at least a dozen schools in the city received bomb threat emails, which later turned out to be hoaxes.
Similarly, on January 28, as many as 13 schools received hoax bomb threats via email, forcing authorities to evacuate campuses and suspend classes.
Last month, police arrested a Bangladeshi national whose email ID was allegedly used to make a bomb threat for some payment.
