Nano bubbles filled with drug may kill cancer cells: Study
Sydney, July 16 : In a step further to identify range of cancer treatments available to patients, scientists have developed drug-filled nano bubbles triggered in the body by X-rays which may help kill the malignant cells.
The tiny bubbles, known as liposomes, are commonly used in pharmacology to encapsulate drugs, making them more effective in the treatment of disease and researchers have now been able to engineer these liposomes to discharge their drug cargo on-demand, once activated by standard X-rays. Initial testing has shown this technique to be highly efficient in killing bowel cancer cells.
"The development and application of various nanomaterial designs for drug delivery is currently a key focus area in nanomedicine," said lead author Wei Deng, fro ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP), Australia.
"Liposomes are already well established as an extremely effective drug-delivery system. Made out of similar material as cell membranes, these 'bubbles' are relatively simple to prepare, can be filled with appropriate medications and then injected into specific parts of the body. The issue however, is in controlling the timely release of the drug from the liposome," Deng added.
For the study, published in the journal Nature Communications, the team embeded gold nanoparticles and the photo-sensitive molecule verteporfin into the wall of the liposome, in a laboratory setting
The X-ray radiation caused the verteporfin to react and produce highly reactive singlet oxygen which destabilisesdthe liposomal membrane, causing the release of the drug, Deng explained.
"The gold nanoparticles are added into the mix as they focus the X-ray energy. This enhances the singlet oxygen generation and hence improves the speed of the membrane breakup," she added.
The liposomes were filled with chemotherapy drug called doxorubicin, which killed the cancer cells far more effectively than without X-ray triggering
Thus, controlling the timely release of the drug from the bubble is very crucial, Deng said.
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CM Siddaramaiah labels Kumaraswamy 'Manuvadi" over Bhagavad Gita curriculum push
Bengaluru (PTI): Karnataka Chief Minister Siddaramaiah on Saturday took a swipe at Union Minister H D Kumaraswamy, by calling him a "Manuvadi" after his alliance with the BJP, for seeking the inclusion of Bhagavad Gita in curriculum for students.
The CM's dig came in response to Kumaraswamy's recent letter to Union Minister for Education Dharmendra Pradhan, requesting the inclusion of the Bhagavad Gita in the curriculum of students.
"After Kumaraswamy joined hands with the BJP for elections, he has become a Manuvadi," Siddaramaiah told reporters here after paying tributes to B R Ambedkar on his 69th death anniversary here.
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Remembering Ambedkar, Siddaramaiah highlighted his contribution to the Constitution and his relentless fight to provide social justice.
The CM noted said fed up with social and caste system in Hinduism, and unable to reform it, Ambedkar accepted Buddhism.
He said, "Ambedkar, towards the end of his life, quit Hinduism and joined Buddhism. He was born in Hinduism, but cannot die in Hinduism, because he could not reform Hinduism, despite several efforts, so he accepted Buddhism."
