Nano bubbles filled with drug may kill cancer cells: Study
Sydney, July 16 : In a step further to identify range of cancer treatments available to patients, scientists have developed drug-filled nano bubbles triggered in the body by X-rays which may help kill the malignant cells.
The tiny bubbles, known as liposomes, are commonly used in pharmacology to encapsulate drugs, making them more effective in the treatment of disease and researchers have now been able to engineer these liposomes to discharge their drug cargo on-demand, once activated by standard X-rays. Initial testing has shown this technique to be highly efficient in killing bowel cancer cells.
"The development and application of various nanomaterial designs for drug delivery is currently a key focus area in nanomedicine," said lead author Wei Deng, fro ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP), Australia.
"Liposomes are already well established as an extremely effective drug-delivery system. Made out of similar material as cell membranes, these 'bubbles' are relatively simple to prepare, can be filled with appropriate medications and then injected into specific parts of the body. The issue however, is in controlling the timely release of the drug from the liposome," Deng added.
For the study, published in the journal Nature Communications, the team embeded gold nanoparticles and the photo-sensitive molecule verteporfin into the wall of the liposome, in a laboratory setting
The X-ray radiation caused the verteporfin to react and produce highly reactive singlet oxygen which destabilisesdthe liposomal membrane, causing the release of the drug, Deng explained.
"The gold nanoparticles are added into the mix as they focus the X-ray energy. This enhances the singlet oxygen generation and hence improves the speed of the membrane breakup," she added.
The liposomes were filled with chemotherapy drug called doxorubicin, which killed the cancer cells far more effectively than without X-ray triggering
Thus, controlling the timely release of the drug from the bubble is very crucial, Deng said.
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Abhishek Sharma's massive century guides SRH to 8-wicket win against PBKS
Hyderabad, Apr 12 (PTI): Opener Abhishek Sharma smashed a superb century and shared a 171-run partnership with Travis Head as Sunrisers Hyderabad made a mockery of the massive 245-run chase, registering an eight-wicket win against Punjab Kings here on Saturday.
SRH scored 247 for 2 with nine balls to spare.
Abhishek clobbered 141 off 55 deliveries studded with 14 fours and 10 big hits, while Head made 66 off 37 balls as the duo undid the good work done by Punjab Kings' captain Shreyas Iyer, who hit a 36-ball 82 after electing to bat first.
Abhishek also become the third-highest scorer in IPL history behind Chris Gayle (175 not out) and Brendon McCullum (158 not out).
Earlier, PBKS openers Priyansh Arya (36 off 13 balls) and Prabhsimran Singh (42 off 23) added 66 runs quickly before Iyer carried on the good work along with Nehal Wadhera (27).
Harshal Patel (4/42) emerged as the most successful SRH bowler, while Sri Lankan right-arm quick Eshan Malinga (2/45) took two wickets.
Brief Scores:
Punjab Kings: 245 for 6 in 20 overs (Shreyas Iyer 82, Marcus Stoinis 34 not out, Priyansh Arya 36, Prabhsimran Singh 42; Harshal Patel 4/42, Eshan Malinga 2/45).
Sunrisers Hyderabad: 247 for 2 in 18.3 overs (Travis Head 66, Abhishek Sharma 141, Heinrich Klaasen 21 not out).
