Nano bubbles filled with drug may kill cancer cells: Study
Sydney, July 16 : In a step further to identify range of cancer treatments available to patients, scientists have developed drug-filled nano bubbles triggered in the body by X-rays which may help kill the malignant cells.
The tiny bubbles, known as liposomes, are commonly used in pharmacology to encapsulate drugs, making them more effective in the treatment of disease and researchers have now been able to engineer these liposomes to discharge their drug cargo on-demand, once activated by standard X-rays. Initial testing has shown this technique to be highly efficient in killing bowel cancer cells.
"The development and application of various nanomaterial designs for drug delivery is currently a key focus area in nanomedicine," said lead author Wei Deng, fro ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP), Australia.
"Liposomes are already well established as an extremely effective drug-delivery system. Made out of similar material as cell membranes, these 'bubbles' are relatively simple to prepare, can be filled with appropriate medications and then injected into specific parts of the body. The issue however, is in controlling the timely release of the drug from the liposome," Deng added.
For the study, published in the journal Nature Communications, the team embeded gold nanoparticles and the photo-sensitive molecule verteporfin into the wall of the liposome, in a laboratory setting
The X-ray radiation caused the verteporfin to react and produce highly reactive singlet oxygen which destabilisesdthe liposomal membrane, causing the release of the drug, Deng explained.
"The gold nanoparticles are added into the mix as they focus the X-ray energy. This enhances the singlet oxygen generation and hence improves the speed of the membrane breakup," she added.
The liposomes were filled with chemotherapy drug called doxorubicin, which killed the cancer cells far more effectively than without X-ray triggering
Thus, controlling the timely release of the drug from the bubble is very crucial, Deng said.
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Will Champai Soren become a game-changer for BJP in Jharkhand polls?
Ranchi: Champai Soren, a prominent figure in Jharkhand’s statehood movement, is contesting the 2024 assembly elections from Seraikela, a seat he has consistently held since 1991.
However, there is a surprising shift in his political journey this year. Having resigned from the Jharkhand Mukti Morcha (JMM) earlier this year, Soren is now representing the BJP, a move that could significantly impact the electoral dynamics in the state.
Soren’s switiching is seen as a strategic benefit for the saffron party, which has been working to expand its appeal among Jharkhand’s tribal communities, a demographic traditionally aligned with the JMM. His departure from the JMM, led by Shibu Soren and his son Hemant Soren, was fueled by dissatisfaction with the state government’s policies, which he claimed had failed to address tribal concerns.
Also known as "Jharkhand’s Tiger" for his instrumental role in the statehood movement of the 1990s, Champai Soren has respect and influence among tribal voters. His decision to switch the party could be a turning point in the BJP’s efforts to gain a stronger hold in a state where tribal votes often decide the outcome.
