London (PTI): Exposure to traffic related air pollution is associated with an increased risk of multiple long-term physical and mental health conditions, according to a study.

This is the largest study worldwide -- conducted on over 364,000 (over 3.6 lakh) people in England -- to examine whether air pollution exposure is linked with the occurrence of multiple long-term health conditions, the researchers said.

The study, published in the journal Frontiers in Public Health, showed that high levels of traffic-related air pollution - fine particulate matter (PM2.5) and nitrogen dioxide (NO2) were associated with an increased risk of having at least two long term health conditions.

The strongest associations were observed for co-occurring neurological, respiratory, cardiovascular and common mental health conditions such as depression and anxiety, the researchers said.

"People with more than one long-term health condition have a lower quality of life and greater dependence on the healthcare system," said Amy Ronaldson, Research Associate at King's College London and first author on the study.

"Our research has indicated that those people that live in areas of higher traffic-related air pollution are at greater risk of having multiple health conditions," Ronaldson said.

However, the study does not prove that air pollution causes multimorbidity, but it does warrant further research in this area, the researchers said.

They analysed data from UK Biobank - a large-scale biomedical database and research resource containing anonymised genetic, lifestyle and health information from half a million UK participants aged between 40 and 69 years.

Participants were assessed for 36 physical and five mental health chronic conditions. Multimorbidity was defined as having two or more of these conditions.

Physical and mental health data from UK Biobank in 2010 were linked with the estimated concentration of air pollution at the residential address of the participants.

The study found that those participants exposed to higher concentrations above 10 microgramme per cubic metre ( g/m3) of fine particulate matter had a 21 per cent increased risk of two or more co-occurring conditions compared to those exposed to concentrations below 10 g/m3.

For participants exposed to above 30 g/m3 of NO2, the study showed a 20 per cent increased risk of having two or more co-occurring conditions compared to those participants that were exposed to concentrations of NO2 below 20 g/m3.

Amongst those with multiple conditions, increased exposure to both PM2.5 and NO2 was linked to a greater severity of the co-occurring conditions, the researchers said.

"How air pollution affects multiple organs and systems at the same time is not yet fully understood, but there is some evidence that mechanisms such as inflammation, oxidative stress and immune activation could be triggered by air particulates, which can cause damage to the brain, heart, blood, lungs and gut," said Ioannis Bakolis from King's College London.

"Our study suggests that it could be through shared mechanisms that air pollution negatively impacts several body systems and increases the likelihood of people developing multiple long term health conditions," said Bakolis, senior author on the study.

Researchers identified several patterns in the associations. The strongest links were primarily between conditions relating to the respiratory system such as asthma and chronic obstructive pulmonary disease as well as the cardiovascular system like atrial fibrillation, coronary heart disease, and heart failure.

The link was also seen with neurological and common mental conditions such as stroke, substance abuse, depression and anxiety, the researchers added.

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London, Nov 22: A bomb disposal squad deployed as a “precaution” to the South Terminal of Gatwick Airport concluded an investigation into a "security incident" on Friday after making a “suspect package” safe.

The South Terminal of Gatwick Airport, the UK's second busiest airport after Heathrow, which was briefly shut owing to the incident reopened following the incident.

The Gatwick is around 45 km south of London.

Two people detained during the enquiries have since been allowed to continue their journey as the airport was opened.

“Police have concluded their investigation into a report of a suspect package at Gatwick Airport. Officers from the EOD (Explosive Ordnance Disposal) team made the package safe, and the airport has been handed back to its operator,” Sussex Police said in an updated statement.

“Two people detained while enquiries were ongoing have subsequently been allowed to continue their journeys. There will remain an increased police presence in the area to assist with passengers accessing the South Terminal for onward travel,” the statement added.

Earlier on Friday, the incident caused severe disruption at the busy airport’s South Terminal, while the North Terminal of Gatwick Airport remained unaffected.

“Police were called to the South Terminal at Gatwick Airport at 8.20 am on Friday (November 22) following the discovery of a suspected prohibited item in luggage,” a Sussex Police statement said.

“To ensure the safety of the public, staff and other airport users, a security cordon has been put in place whilst the matter is dealt with. As a precaution, an EOD (Explosive Ordnance Disposal) team is being deployed to the airport. This is causing significant disruption and some roads around the South Terminal have been closed. We’d advise the public to avoid the area where possible,” it said.

Footage on social media taken outside the airport showed crowds of frustrated travellers being moved away from the terminal building.

Gatwick said it was working hard to resolve the issue.

“A large part of the South Terminal has been evacuated as a precaution while we continue to investigate a security incident," the airport said in a social media post.

“Passengers will not be able to enter the South Terminal while this is ongoing. The safety and security of our passengers and staff remain our top priority. We are working hard to resolve the issue as quickly as possible.”

Train and bus services that serve the airport were also impacted while the police carried out their inquiries.

In an unrelated incident in south London on Friday morning, the US Embassy area in Nine Elms by the River Thames was the scene of a controlled explosion by Scotland Yard dealing with what they believe may have been a “hoax device”.

“We can confirm the 'loud bang' reported in the area a short time ago was a controlled explosion carried out by officers,” the Metropolitan Police said in a post on X.

“Initial indications are that the item was a hoax device. An investigation will now follow. Some cordons will remain in place for the time being but the majority of the police response will now be stood down,” it added.