Healthy diet for woman can ensure good brain health for grandchildren, genetic model: Study
New Delhi (PTI): Mothers who eat apples and herbs during their early pregnancy could be protecting the brain health of their children and grandchildren, a Monash University study using genetic models has found.
The discovery is part of a project that found a mother's diet can affect not just her child's brain but also those of her grandchildren.
Published in Nature Cell Biology, the Monash Biomedicine Discovery Institute study found that certain foods could help prevent the deterioration of brain function.
This study used roundworms (Caenorhabditis elegans) as the genetic model because many of their genes are also found in humans, allowing insights into human cells.
The researchers found that a certain molecule present in apples and herbs such as basil, rosemary, thyme, oregano, and sage helped in reducing the breakdown of communication cables needed for the brain to work properly.
Senior professor Roger Pocock, with his team, investigated nerve cells in the brain that connect with each other through about 8,50,000 kilometres of cables called axons. For axons to function and survive, essential materials need to be transported along an internal structure that contains microtubules.
Pocock explained that a malfunction that caused the axons to become fragile can lead to brain dysfunction and neurodegeneration.
He said his team used a genetic model with fragile axons that break as animals age. "We tried to find whether natural products found in the diet can stabilise these axons and prevent breakage," he explained.
"We identified a molecule found in apples and herbs that reduces axon fragility -- ursolic acid. How? We found that ursolic acid causes a gene to turn on that makes a specific type of fat. This particular fat also prevented axon fragility as animals age by improving axon transport and therefore its overall health."
Pocock said this type of fat, known as a sphingolipid, had to travel from the mother's intestine, where food is digested, to eggs in the uterus for it to protect axons in the next generation. He said while the results were promising, they still need to be confirmed in humans.
"This is the first time that a lipid/fat has been shown to be inherited," he said. "Further, feeding the mother the sphingolipid protects the axons of two subsequent generations. This means a mother's diet can affect not just their offspring's brain but potentially subsequent generations. Our work supports a healthy diet during pregnancy for optimal brain development and health," Pocock said.
Read the full paper published in Nature Cell Biology, titled 'An Intestinal Sphingolipid Confers Intergenerational Neuroprotection'.
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Confident we are going to win Kerala: Shashi Tharoor
New Delhi (PTI): Congress leader Shashi Tharoor on Thursday expressed confidence in the victory of the United Democratic Front (UDF) in Kerala, saying the Congress-led alliance will win more than 75 seats out of the total 140 in the state.
Tharoor, who hails from Kerala, said he was not surprised to see the results of the exit polls, most of which predicted a victory for the UDF that has been out of power for 10 years in the state.
"We have been on the ground. I have campaigned in 59 constituencies across 12 districts out of 14. I was very confident we are going to win.
"Everything that I have picked up from not just my party colleagues and workers but also from other observers, media and others have always convinced me that we were going to score a comfortable win of above 75 seats. And all the (exit) polls have confirmed the same thing," he told reporters here.
The Thiruvananthapuram MP said he was not surprised to see the results of the exit polls but in general he was not a big fan of exit polls in India.
"Because ours is not purely a homogenous society. We have to take into account gender issue, caste issue, class issue, regional disparities. You never get a convincingly large enough sample to give an accurate poll and now there is the additional complication that we have heard about in West Bengal this year that many people are unwilling to answer the questions of the pollsters," he said.
The Congress leader said normally, it used to be below 10 per cent that people said that they would not answer.
"Even if you are a reputable exit pollster, in Bengal, one polling company has said 60 per cent of people refused to answer. So, what is the worth of a poll where 60 per cent of your respondents have not answered," he said.
Several exit polls on Wednesday predicted a comeback by the Congress-led UDF in Kerala after 10 years, dethroning the CPI(M)-led Left Democratic Front (LDF).
Polling for the 140-member Kerala assembly was held on April 9. Results of assembly elections in West Bengal, Tamil Nadu, Assam, Puducherry, besides Kerala, will be announced on May 4.
