BA.2 is like Omicron's sister; Here's what we know about it so far
Queensland, Feb 3 (The Conversation): Cases of the SARS-CoV-2 variant Omicron have escalated globally over the past two months, with many countries experiencing peaks higher than previous variants.
Now we're seeing cases of a sub-variant of Omicron, known as BA.2, emerge in Australia and more than 50 countries.
Rather than a daughter of the Omicron variant BA.1 (or B.1.1.529), it's more helpful to think of BA.2 as Omicron's sister.
Remind me, what is a variant?
Viruses, and particularly RNA viruses such as SARS-CoV-2, make lots of mistakes when they reproduce. They can't correct these mistakes, so they have a relatively high rate of errors, or mutations, and are constantly evolving.
When the genetic code of a virus changes as a result of these mutations, it's referred to as a variant.
Omicron is a highly divergent variant, having accumulated more than 30 mutations in the spike protein. This has reduced the protection of antibodies from both prior infection and vaccination, and increased transmissibility.
When do health authorities worry about a new variant?
If changes in the genetic code are thought to have the potential to impact properties of the virus that make it more harmful, and there's significant transmission in multiple countries, it will be deemed a variant of interest .
If a variant of interest is then shown to be more infectious, evade protection from vaccination or previous infection, and/or impact the performance of tests or treatments, it is labelled a variant of concern .
The World Health Organisation (WHO) classified Omicron a variant of concern on November 26 because of its potential to cause higher reinfection rates, increased transmissibility and reduced vaccine protection.
What is the Omicron lineage?
A lineage, or sub-variant, is a genetically closely related group of virus variants derived from a common ancestor.
The Omicron variant comprises three sub-lineages: B.1.1.529 or BA.1, BA.2 and BA.3.
While the WHO has not given BA.2 a separate classification, the United Kingdom has labelled BA.2 a variant under investigation . So not yet a variant of interest or concern, based on WHO definitions, but one that is being watched closely.
This is not the first variant to have sub-lineages. Late last year, Delta plus or AY.4.2 was reported widely, then Omicron came along.
What's different about BA.2?
While the first sequences of BA.2 were submitted from the Philippines and we have now seen thousands of cases, including in the United States, the UK and some in Australia its origin is still unknown.
The exact properties of BA.2 are also still being investigated. While there is no evidence so far that it causes more severe disease, scientists do have some specific concerns.
1. It's harder to differentiate
A marker that helped differentiate Omicron (BA.1) from other SARS-CoV-2 variants on PCR tests is the absence of the the S gene, known as S gene target failure . But this is not the case for BA.2.
The inability to detect this lineage in this way has led some to label it the stealth sub-variant .
But it doesn't mean we can't diagnose BA.2 with PCR tests. It just means when someone tests positive for SARS-CoV-2, it will take us a little longer to know which variant is responsible, through genome sequencing. This was the case with previous variants.
2. It may be more infectious
Perhaps most concerning is emerging evidence BA.2 may be more infectious than the original Omicron, BA.1.
A preliminary study from Denmark, where BA.2 has largely replaced BA.1, suggests BA.2 increases unvaccinated people's susceptibility of infection by just over two times when compared to BA.1.
The researchers suggest fully vaccinated people are 2.5 times more susceptible to BA.2 than BA.1, and those who were booster vaccinated are nearly three times more susceptible.
The study examined more than 2,000 primary household cases of BA.2 to determine the number of cases that arose during a seven-day follow up period.
The researchers also estimated the secondary attack rate (basically, the probability infection occurs) to be 29% for households infected with BA.1 versus 39% for those infected with BA.2.
This Danish study is still a preprint, meaning it's yet to be checked by independent scientists, so more research is needed to confirm if BA.2 is truly more infectious than BA.1.
We're likely to see new variants We should expect new variants, sub-variants and lineages to continue to emerge. With such high levels of transmission, the virus has abundant opportunity to reproduce and for errors or mutations to continue to arise.
The way to address this, of course, is to try to slow transmission and reduce the susceptible pool of hosts in which the virus can freely replicate.
Strategies such as social distancing and mask-wearing, as well as increasing vaccination rates globally, will slow the emergence of new variants and lineages. (The Conversation)
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Grok obscene AI content: X submits response, IT Ministry examining it, say sources
New Delhi (PTI): The IT Ministry is examining the response and submissions made by X following a government directive to crack down on misuse of artificial intelligence chatbot Grok by users for the creation of sexualised and obscene images of women and minors, sources said.
X had been given extended time until Wednesday, 5 PM to submit a detailed Action Taken Report to the ministry, after a stern warning was issued to the Elon Musk-led social media platform over indecent and sexually-explicit content being generated through misuse of AI-based services like 'Grok' and other tools.
Sources told PTI that X has submitted their response, and it is under examination.
The details of X's submission were, however, not immediately known.
On Sunday, X's 'Safety' handle said it takes action against illegal content on its platform, including Child Sexual Abuse Material (CSAM), by removing it, permanently suspending accounts, and working with local governments and law enforcement as necessary.
"Anyone using or prompting Grok to make illegal content will suffer the same consequences as if they upload illegal content," X had said, reiterating the stance taken by Musk on illegal content.
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On January 2, the IT Ministry pulled up X and directed it to immediately remove all vulgar, obscene and unlawful content, especially generated by Grok (X's built-in artificial intelligence interface) or face action under the law.
In the directive on Friday, the ministry asked the US-based social media firm to submit a detailed action taken report (ATR) within 72 hours, spelling out specific technical and organisational measures adopted or proposed in relation to the Grok application; the role and oversight exercised by the Chief Compliance Officer; actions taken against offending content, users and accounts; as well as mechanisms to ensure compliance with the mandatory reporting requirement under Indian laws.
The IT Ministry, in the ultimatum issued, noted that Grok AI, developed by X and integrated on the platform, is being misused by users to create fake accounts to host, generate, publish or share obscene images or videos of women in a derogatory or vulgar manner.
"Importantly, this is not limited to creation of fake accounts but also targets women who host or publish their images or videos, through prompts, image manipulation and synthetic outputs," the ministry said, asserting that such conduct reflects a serious failure of platform-level safeguards and enforcement mechanisms, and amounts to gross misuse of artificial intelligence (AI) technologies in violation of stipulated laws.
The government made it clear to X that compliance with the IT Act and rules is not optional, and that the statutory exemptions under section 79 of the IT Act (which deals with safe harbour and immunity from liability for online intermediaries) are conditional upon strict observance of due diligence obligations.
"Accordingly, you are advised to strictly desist from the hosting, displaying, uploading, publication, transmission, storage, sharing of any content on your platform that is obscene, pornographic, vulgar, indecent, sexually explicit, paedophilic, or otherwise prohibited under any law...," the ministry said.
The government warned X in clear terms that any failure to observe due diligence obligations shall result in the loss of the exemption from liability under section 79 of the IT Act, and that the platform will also be liable for consequential action under other laws, including the IT Act and Bharatiya Nyaya Sanhita.
It asked X to enforce user terms of service and AI usage restrictions, including ensuring strong deterrent measures such as suspension, termination and other enforcement actions against violating users and accounts.
X has also been asked to remove or disable access "without delay" to all content already generated or disseminated in violation of applicable laws, in strict compliance with the timelines prescribed under the IT Rules, 2021, without, as such, vitiating the evidence.
Besides India, the platform has drawn flak in the UK and Malaysia too. Ofcom, the UK's independent communications regulator, in a recent social media post, said: "We are aware of serious concerns raised about a feature on Grok on X that produces undressed images of people and sexualised images of children".
"We have made urgent contact with X and xAI to understand what steps they have taken to comply with their legal duties to protect users in the UK. Based on their response, we will undertake a swift assessment to determine whether there are potential compliance issues that warrant investigation," Ofcom said.
