10 new cancer risk genes identified
London, July 12 : Using publicly available data, researchers have identified 10 new genes that are predisposed to ovarian and breast cancer among others, an advance that would contribute to improving cancer diagnoses and prevention in the future.
There are many genetic causes of cancer. While some mutations are inherited from parents, others are acquired all throughout life due to external factors or due to mistakes in copying DNA.
In the study, published in Nature Communications, a team of researchers developed a new statistical method named ALFRED and identified 13 candidate cancer predisposition genes, of which 10 are new from tumour sequencing data.
"We applied our method to the genome sequences of more than 10,000 cancer patients with 30 different tumour types and identified known and new possible cancer predisposition genes that have the potential to contribute substantially to cancer risk," said principal investigator Ben Lehner, ICREA -- Catalan Institution for Research and Advanced Studies in Spain.
"Our computational method uses an old idea that cancer genes often require 'two hits' before they cause cancer. We developed a method that allows us to systematically identify these genes from existing cancer genome datasets," said Solip Park, from the Centre for Genomic Regulation (CRG) -- a Barcelona-based research facility.
The method allows researchers to find risk variants without a control sample, meaning they do not need to compare cancer patients to groups of healthy people.
"Our results show that the new cancer predisposition genes may have an important role in many types of cancer. For example, they were associated with 14 per cent of ovarian tumours, seven per cent of breast tumours and to about one in 50 of all cancers," Park said.
Inherited variants in one of the newly-proposed risk genes -- NSD1 -- may also be implicated in at least three out of 1,000 cancer patients, the researchers explained.
For the study, the team combined data from many different projects and by applying a new computational method, were able to identify important cancer genes that were not identified by the original studies.
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Agra: Karni Sena holds armed rally against Samajwadi Party’s MP, police stand down
Agra: An armed rally by Karni Sena has sparked serious concerns over law enforcement and public safety, in Agra on Friday, openly brandishing swords and sticks while raising provocative slogans against Samajwadi Party MP Dr. Ramji Lal Suman. The rally, held to mark the birth anniversary of Rajput icon Rana Sanga, witnessed the participation of thousands of Karni Sena members, many of whom were seen carrying weapons in the presence of the police.
Despite the large police deployment, including PAC personnel and senior officers such as the Additional Commissioner, no preventive or punitive action was taken by law enforcement authorities as the rally progressed. Visuals that have now gone viral on social media show rally participants waving swords, raising slogans, and even threatening prominent political figures, including former Chief Minister and SP chief Akhilesh Yadav.
The rally was reportedly organized to press for action against Dr. Ramji Lal Suman, the SP MP from Agra, who had earlier made a remark citing historical sources that Rana Sanga had invited Mughal ruler Babar to India. Although Suman had publicly apologized for the remark and clarified that it was not intended to hurt anyone’s sentiments, the Karni Sena had reacted sharply, terming it an insult to Rajput pride.
On March 26, 2025, soon after Suman's statement, Karni Sena members had reportedly attacked the MP's residence in Agra. Stones were pelted, vehicles were vandalized, windows smashed, and even police personnel were injured during the violence. Despite the severity of the incident, no major crackdown followed. The April 12 rally has now reignited concerns about the administration's handling of the group.
The Karni Sena had publicly declared their intent to organize the rally irrespective of police permission. Their national president, Raj Shekhawat, had even stated that they would march toward Suman’s house if their demands were not met. In anticipation, Agra Police had increased security outside the MP’s residence, ordered an additional 1,200 helmets and 1,000 batons, deployed drones, and set up barricades in sensitive zones.
However, when the rally took place, the arrangements appeared insufficient and ineffective. Crowd control measures were not enforced, and police presence appeared symbolic rather than deterrent. According to reports, the participants ignored police warnings, waving weapons and sticks in full view of law enforcement, and shouting slogans against SP leaders.
In a particularly alarming development, a Karni Sena leader can be seen in a viral video threatening to kill SP chief Akhilesh Yadav. Despite this direct threat, there has been no confirmation from the police on any action taken against the speaker.
The silence of the administration during the rally, as well as in response to the earlier March 26 attack on the MP's house, has raised sharp criticism. Many political observers and citizens have questioned why such actions were tolerated and why the law was not enforced when the potential for violence was already known.
The Samajwadi Party has described these incidents as targeted attacks against the Dalit community and political intimidation. Akhilesh Yadav has alleged that Karni Sena operates with tacit support from the BJP, and that the threats and violence are being allowed under the current regime.
Social media users have also reacted strongly to the visuals of the rally. Several users questioned whether other groups—such as protesting farmers or students—would have been allowed to behave similarly without police action. Some commentators have called the event an open challenge to law and order in Uttar Pradesh, especially in light of the Supreme Court’s recent critical remarks on the deteriorating situation in the state.
