COVID-19 patients can be categorised into three groups, say scientists
Washington: Scientists have identified three different types of COVID-19 disease traits in patients, depending on their comorbidities, complications, and clinical outcomes, an advance that may help target future interventions to the most risk-prone individuals.
The new study, published in the journal PLOS ONE, analysed the electronic health records (EHRs) from 14 hospitals in the midwestern US and from 60 primary care clinics in the state of Minnesota.
According to the researchers, including those from the University of Minnesota in the US, the study included 7,538 patients with confirmed COVID-19 between March 7 and August 25, 2020, of which 1,022 patients required hospitalisation.
Close to 60 per cent of the patients included in the research presented with what the researchers called "phenotype II."
They said about 23 per cent of the patients presented with "phenotype I," or the "adverse phenotype," which was associated with the worst clinical outcomes.
The researchers said these patients had the highest level of comorbidies related to heart and kidney dysfunction.
According to the study, 173 patients, or 16.9 per cent presented with "phenotype III," or the "favorable phenotype," which the scientists said was associated with the best clinical outcomes.
While this group had the lowest complication rate and mortality, the scientists said these patients had the highest rate of respiratory comorbidities as well as a 10 per cent greater risk of hospital readmission compared to the other phenotypes.
Overall, they said phenotypes I and II were associated with 7.30-fold and 2.57-fold increases in hazard of death relative to phenotype III.
Based on the results, the scientists said such phenotype-specific medical care could improve COVID-19 outcomes.
However, they believe further studies are needed to determine the utility of these findings in clinical practice.
"Patients do not suffer from COVID-19 in a uniform matter. By identifying similarly affected groups, we not only improve our understanding of the disease process, but this enables us to precisely target future interventions to the highest risk patients," the scientists added.
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Railways announces 84 special trains following IndiGo flight cancellations
New Delhi (PTI): The Railways announced 84 special trains across all zones for Saturday to help people facing travel disruptions due to the mass flight cancellations by IndiGo.
In a coordinated move by the Railway Ministry, the trains, which are to make 104 trips, were arranged in the shortest possible time after analysis of train traffic situations in major cities such as New Delhi, Mumbai, Chennai, Bengaluru, Patna, and Howrah, among others.
"The number of special trains and their trips might increase further depending on the traffic scenario. All zones have been asked to make use of all available resources, including rolling stock as well as manpower, to safely operate these trains for the convenience of lakhs of passengers stranded at different parts of the country due to flight cancellations," said Dilip Kumar, Executive Director, Information & Publicity, Railway Board.
Officials said efforts are being made to make people aware about the trains, and some divisions have even disseminated information at nearby airports to help passengers.
South Eastern Railway has issued a press release and informed the Airport Authority to display information regarding the newly introduced special train services.
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"Western Railway will run seven special trains on a special fare between Mumbai Central-New Delhi, Mumbai Central-Bhiwani, Mumbai Central-Shakur Basti, Bandra Terminus-Durgapura, Valsad-Bilaspur, Sabarmati-Delhi and Sabarmati-Delhi Sarai Rohilla stations," a press note said.
Similarly, South Central Railway on Saturday announced that it would run four special trains to manage the surge in passengers resulting from the large-scale cancellation of IndiGo flights.
Central Railway and Northern Railway have planned 14 and 10 special trains respectively, and officials said these numbers are being further reviewed to meet any rising requirements.
Other zones have also issued notifications regarding special trains along with their schedules.
For at least five days in a row, IndiGo flight operations have significantly disrupted, with a large number of cancellations and delays causing hardships to thousands of passengers. In many cases, baggages have been misplaced.
