New York, April 22: Researchers have found that activity in decision-making brain regions of people who use recreational stimulants can predict who will discontinue their use and who will develop a drug use disorder.
The findings of the study, led by Martin Paulus of Laureate Institute of Brain Research in Oklahoma, suggested that an inability to learn from previous risky decisions in some people may predispose them to continue drug use despite the negative consequences.
"Our sample of recreational users offers a unique approach to studying addiction," said first author Melanie Blair, a doctoral student in the laboratory of Jennifer Stewart of City University of New York.
"By finding differences between our groups prior to problematic use, our results suggest that certain brain patterns might be existing vulnerabilities that predispose an individual to addiction," Blair added.
For the study, published in the journal Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, researchers used brain imaging to measure the activity of several brain regions involved in decision making in 144 young adults.
The study measured brain activity in young adults using recreational stimulants, including cocaine and the prescription amphetamines Adderall and Ritalin, and followed up three years later to determine the participants' outcome.
During the brain scans, the participants performed a task requiring them to make risky or safe decisions. Although all participants in the study were experimenting with stimulants at the time, some showed a tendency for making riskier choices.
"Compared to individuals who stopped using, those who later developed problem use were more reactive to rewards and showed weaker activity in regions of the brain that are critical for decision making," Blair said.
These participants had lower activity in a brain circuit that provides feedback on risky decisions, suggesting they might not be as good at adapting their behaviour-based on previous experiences, the researcher added.
Weaker brain activity in regions associated with decision making also predicted greater marijuana use in the future, they noted.
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Israeli Prime Minister Benjamin Netanyahu dismisses defence minister in surprise announcement
Jerusalem, Nov 5: Israeli Prime Minister Benjamin Netanyahu on Tuesday dismissed his popular defence minister, Yoav Gallant, in a surprise announcement that came as the country is embroiled in wars on multiple fronts across the region.
Netanyahu and Gallant have repeatedly been at odds over the war in Gaza. But Netanyahu had avoided firing his rival. Netanyahu cited “significant gaps” and a “crisis of trust” between the men in his Tuesday evening announcement.
“In the midst of a war, more than ever, full trust is required between the prime minister and defence minister,” Netanyahu said. “Unfortunately, although in the first months of the campaign there was such trust and there was very fruitful work, during the last months this trust cracked between me and the defence minister.”
In the early days of the war, Israel's leadership presented a unified front as it responded to Hamas' October 7, 2023, attack. But as the war dragged on and spread to Lebanon, key policy differences have emerged. While Netanyahu has called for continued military pressure on Hamas, Gallant had taken a more pragmatic approach, saying that military force has created the necessary conditions for a diplomatic deal that could bring home hostages held by the Hamas group.
Gallant, a former general who has gained public respect with a gruff, no-nonsense personality, said in a statement: “The security of the state of Israel always was, and will always remain, my life's mission."
Gallant has worn a simple, black buttoned shirt throughout the war in a sign of sorrow over the October 7 attack and developed a strong relationship with his US counterpart, Defence Secretary Lloyd Austin.
A previous attempt by Netanyahu to fire Gallant in March 2023 sparked widespread street protests against Netanyahu. He also flirted with the idea of dismissing Gallant over the summer but held off until Tuesday's announcement.
Gallant will be replaced by Foreign Minister Israel Katz, a Netanyahu loyalist and veteran Cabinet minister who was a junior officer in the military. Gideon Saar, a former Netanyahu rival who recently rejoined the government, will take the foreign affairs post.
Netanyahu has a long history of neutralising his rivals. In his statement, he claimed he had made “many attempts” to bridge the gaps with Gallant.
“But they kept getting wider. They also came to the knowledge of the public in an unacceptable way, and worse than that, they came to the knowledge of the enemy - our enemies enjoyed it and derived a lot of benefit from it,” he said.
