Experimental drug can halt Parkinson's progression: Study
July 3: US researchers have developed an experimental drug that potentially slows down the progression of Parkinson's disease as well as its symptoms.
In experiments performed with cultures of human brain cells and live mouse models, researchers from the Johns Hopkins University in Maryland reported that the drug blocked the degradation of brain cells that is the hallmark of Parkinson's disease.
"It is amazingly protective of target nerve cells," said Ted Dawson, Professor at the University's School of Medicine.
The drug, named NLY01, is similar to compounds used to treat diabetes and is expected to move to clinical trials this year.
If successful in humans, it could be one of the first treatments to directly target the progression of Parkinson's, not just the muscle rigidity, spasmodic movements, fatigue, dizziness, dementia and other symptoms of the disorder, Dawson said in the paper published in the journal Nature Medicine
In a preliminary experiment in laboratory-grown human brain cells, Dawson's team treated human microglia -- a brain cell type that sends signals throughout the central nervous system in response to infection or injury -- with NLY01 and found that they were able to turn the activating signals off.
Further, the researchers injected the mice with alpha-synuclein -- the protein known to be the primary driver of Parkinson's disease -- and the mice treated with NLY01 maintained normal physical function and had no loss of dopamine neurons, indicating that the drug protected against the development of Parkinson's disease.
In another experiment, the team used mice that were genetically engineered to naturally produce more human-type alpha-synuclein typically used to model human Parkinson's disease that runs in families.
While under normal conditions, these so-called transgenic mice will succumb to the disease in 387 days, those treated with NLY01 extended the lives by over 120 days.
However, the experimental drug must still be tested for safety as well as effectiveness in people, Dawson cautioned.
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60 Indians forced into ʼcyber slavery' rescued from Myanmar, five arrested
Mumbai(PTI): The cyber wing of Maharashtra Police has rescued more than 60 Indian nationals who had been forced into cyber slavery in Myanmar and arrested five agents including a foreign national, an official said here on Friday.
Maharashtra Cyber has registered three First Information Reports in this regard, he said.
The racketeers contacted the victims through social media platforms and offered them high-paying jobs in Thailand and other East Asian countries, he said.
The agents arranged passports and flight tickets for the victims and sent them to Thailand on tourist visas. After landing in the country, they were sent to the Myanmar border where they were made to cross a river in small boats.
On entering Myanmar, the victims were taken to guarded compounds controlled by armed rebel groups where they were forced to commit cyber frauds ranging from `digital arrest' scams to fake investment schemes on an industrial scale.
Maharashtra Cyber along with other agencies recued the victims, the official said, without giving details as to whether the operation was carried out inside Myanmar.
Questioning of the victims threw light on a network of agents and fraudulent call center companies which lured job aspirants from India, he said.
Some of these companies operated under the garb of employment agency.
Manish Grey alias Maddy, Taisan alias Aaditya Ravi Chandran, Rupnarayan Ramdhar Gupta, Jensi Rani D and Chinese-Kazakhstani national Talaniti Nulaxi were arrested for allegedly acting as recruitment agents.
Manish Grey alias Maddy is a professional actor who has appeared in web series and television shows, the official said.
Along with others, Grey allegedly recruited unsuspecting individuals and facilitated their trafficking to Myanmar, he added.
Talaniti Nulaxi was allegedly planning to set up a unit in India to commit cyber crimes, he said, adding that further probe was on.
