Experimental drug can halt Parkinson's progression: Study
July 3: US researchers have developed an experimental drug that potentially slows down the progression of Parkinson's disease as well as its symptoms.
In experiments performed with cultures of human brain cells and live mouse models, researchers from the Johns Hopkins University in Maryland reported that the drug blocked the degradation of brain cells that is the hallmark of Parkinson's disease.
"It is amazingly protective of target nerve cells," said Ted Dawson, Professor at the University's School of Medicine.
The drug, named NLY01, is similar to compounds used to treat diabetes and is expected to move to clinical trials this year.
If successful in humans, it could be one of the first treatments to directly target the progression of Parkinson's, not just the muscle rigidity, spasmodic movements, fatigue, dizziness, dementia and other symptoms of the disorder, Dawson said in the paper published in the journal Nature Medicine
In a preliminary experiment in laboratory-grown human brain cells, Dawson's team treated human microglia -- a brain cell type that sends signals throughout the central nervous system in response to infection or injury -- with NLY01 and found that they were able to turn the activating signals off.
Further, the researchers injected the mice with alpha-synuclein -- the protein known to be the primary driver of Parkinson's disease -- and the mice treated with NLY01 maintained normal physical function and had no loss of dopamine neurons, indicating that the drug protected against the development of Parkinson's disease.
In another experiment, the team used mice that were genetically engineered to naturally produce more human-type alpha-synuclein typically used to model human Parkinson's disease that runs in families.
While under normal conditions, these so-called transgenic mice will succumb to the disease in 387 days, those treated with NLY01 extended the lives by over 120 days.
However, the experimental drug must still be tested for safety as well as effectiveness in people, Dawson cautioned.
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'Warm and engaging atmosphere reigned', Shashi Tharoor on Putin banquet
New Delhi (PTI): Senior Congress leader Shashi Tharoor, who on Friday attended a banquet for Russian President Vladimir Putin at the Rashtrapati Bhawan, on Saturday described the atmosphere there as "warm" and "engaging", and said he enjoyed his conversations with many of the attendees.
Tharoo’s remarks came a day after President Droupadi Murmu hosted a banquet for the visiting Russian president at the Rashtrapati Bhavan here.
“Attended the @rashtrapatibhvn banquet for President Putin last night. A warm and engaging atmosphere reigned. Enjoyed my conversations with many of the attendees, especially my dining companions from the Russian delegation!" Tharoor said in a social media post.
Murmu, while welcoming President Putin and his delegation at the banquet, had said that his visit marked an important milestone -- the 25th anniversary of the India-Russia strategic partnership, which was established in October 2000 during his first visit to the country as president.
Murmu also appreciated Putin's support and personal commitment to the India-Russia special and privileged strategic partnership.
The Congress on Friday said that the leaders of the opposition, Mallikarjun Kharge and Rahul Gandhi, were not invited to the banquet, and took a swipe at Tharoor for accepting the invite.
The party’s media and publicity department head, Pawan Khera, accused the government of breaking protocols daily and not believing in democratic principles.
“There is no invite to both the LoPs, Mr (Mallikarjun) Kharge and Mr (Rahul) Gandhi. This comes as a surprise, but I don't think we should be surprised. This government is known to be breaching all protocols. What else to say, ask the government,” Khera said on Friday.
Asked about Tharoor accepting the invite for the banquet, Khera said, "Ask Mr Tharoor. All of us who are in the party, if our leaders don't get invited and we get invited, we need to question our own conscience and listen to our conscience. Politics has been played in inviting or not inviting people, which in itself is questionable, and those who accept such an invite are also questionable."
“We would have listened to our voice of conscience,” he added.
Earlier, Tharoor had said that there was a time when the chairman of the external affairs committee was routinely invited, but that practice seems to have stopped some years ago.
On Thursday, Congress leader Rahul Gandhi alleged that the government tells visiting foreign dignitaries not to meet the leader of opposition due to its "insecurity".
His remarks came hours ahead of Putin's two-day visit to India.
