First 3D-printed human corneas can aid transplants
London, May 30: In a first, British scientists have 3D printed human corneas that could cut down shortage of eye donors available for transplant.
In the research, researchers from Britain's Newcastle University, mixed stem cells (human corneal stromal cells) from a healthy donor cornea with alginate and collagen to create a solution that could be printed or a "bio-ink".
Using a simple low-cost 3D bio-printer, the bio-ink was successfully extruded in concentric circles to form the shape of a human cornea. It took less than 10 minutes to print.
"Our unique gel -- a combination of alginate and collagen -- keeps the stem cells alive whilst producing a material which is stiff enough to hold its shape but soft enough to be squeezed out the nozzle of a 3D printer," said lead author Che Connon, a professor at the varisty.
The results published in the journal, Experimental Eye Research, also stated that the stem cells could culture -- or grow.
"...we have a ready to use bio-ink containing stem cells allowing users to start printing tissues without having to worry about growing the cells separately," Connon added.
According to the researchers, there is a significant shortage of corneas available to transplant, with 10 million people worldwide requiring surgery to prevent corneal blindness as a result of diseases such as trachoma, an infectious eye disorder.
Further, the study also demonstrated that the cornea could also be built to match a patient's unique specifications.
The dimensions of the printed tissue were originally taken from an actual cornea. By scanning a patient's eye, they could use the data to rapidly print a cornea which matched the size and shape, the team explained.
"...what we have shown is that it is feasible to print corneas using coordinates taken from a patient eye and that this approach has potential to combat the world-wide shortage," Connon said.
However, the researchers admitted that further investigations on 3D printed corneas are needed before they could be used in transplants.
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MP: 7-year-old girl raped and murdered; minor relative detained
Barwani (MP), Jan 28 (PTI) Police on Wednesday detained a 17-year-old relative of a seven-year-old girl in Barwani district of Madhya Pradesh for allegedly raping her and killing her by throwing her into a canal, a police official said.
Superintendent of Police Jagdish Dawar told reporters that the body of the child was recovered from the Indira Sagar Canal on January 26, following information from residents of a village in the Rajpur police station area of the district.
He said the post-mortem report concluded severe injuries to the girl’s private parts and attributed her death to drowning.
Dawar said a 17-year-old boy, a close relative of the girl, has been detained in connection with the rape-murder.
The teenager told the police that he kidnapped the girl from her home on the night of January 25 while her family members were asleep, took her to a nearby canal and raped her, according to the official.
When the girl started screaming during the sexual assault, the minor boy allegedly threw her into the canal, with the intention of killing her. The child drowned in the water body, the official said.
The detained minor will be produced in a juvenile court.
A case has been registered under the Protection of Children from Sexual Offences Act and the Bharatiya Nyaya Sanhita, and an investigation is underway, he added.
