Ketamine can cut depression, suicidality rapidly: Study
New York, April 16: Recreational drug Ketamine is likely to have fast-acting benefits in treating symptoms of depression as well as reducing suicidal thoughts, say researchers, including one of an Indian-origin.
The findings of the trial, published in the American Journal of Psychiatry, showed use of Ketamine, also licensed as an anaesthetic, through a nasal spray, led to significant improvements in depressive symptoms and reduction in suicidal thoughts in the first 24 hours.
Esketamine could be an important treatment to bridge the gap as it can help in the rapid treatment compared to the delayed effects of most common antidepressants, which take four to six weeks to become fully effective, said Jaskaran B. Singh, from the Janssen Research & Development in San Diego, US.
The results support nasal spray esketamine as a possible effective rapid treatment for depressive symptoms in patients assessed to be at imminent risk for suicide, the researchers noted.
For the study, a small group of participants randomly assigned to one of two groups - either receiving esketamine or placebo twice a week for four weeks, and found a significant improvement in depression scores and decreased suicidal ideation in the esketamine group compared to the placebo group at four hours and at 24 hours.
However, at 25 days, the effects had levelled out.
While there esketamine dependence or misuse was not observed in the trial, the researchers suggested for effective controls on the distribution and use of ketamine.
They argued that steps to control the use of ketamine would not be aimed at preventing its use for beneficial purposes but would allow for treatment to "continue to be available to those with need, while the population that is at-risk for abuse is protected from an epidemic of misuse."
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India, US trade team to start three-day talks from Dec 10: Sources
New Delhi (PTI): India and the United States will commence three-day talks on the first phase of their proposed bilateral trade agreement here from December 10, sources said.
The visit is crucial as India and the US are working to finalise the first tranche of the pact.
"The three-day talks will start on December 10. It will conclude on December 12, and it is not a formal round of talks," said one of the sources.
The US team will be led by Deputy United States Trade Representative (USTR) Rick Switzer.
This visit of the US officials marks their second trip since the imposition of a 25 per cent tariff and an additional 25 per cent penalty on Indian goods entering the American market due to the purchase of Russian crude oil.
On September 16, the US officials last visited India.
On September 22, Commerce and Industry Minister Piyush Goyal also led an official delegation to the US for trade talks. Goyal had also visited Washington in May.
While the USA's chief negotiator for the pact is Assistant US Trade Representative for South and Central Asia Brendan Lynch, the Indian side is led by Joint Secretary in the Department of Commerce Darpan Jain.
The talks are also important as Commerce Secretary Rajesh Agrawal has recently stated that India is hopeful of reaching a framework trade deal with the US this year itself, which should address the tariff issue to the benefit of Indian exporters.
While noting that the Bilateral Trade Agreement (BTA) will take time, Agrawal has added that India is engaged in protracted negotiations with the US on a framework trade deal that will address the reciprocal tariff challenge faced by Indian exporters.
India and the US are having two parallel negotiations -- one on a framework trade deal to address tariffs and another on a comprehensive trade deal.
In February, leaders of the two countries directed officials to negotiate an agreement.
It was planned to conclude the first tranche of the pact by the fall of 2025. So far, six rounds of negotiations have been held. The agreement aims to more than double bilateral trade to USD 500 billion by 2030, from the current USD 191 billion.
The US remained India's largest trading partner for the fourth consecutive year in 2024-25, with bilateral trade valued at USD 131.84 billion (USD 86.5 billion exports).
The US accounts for about 18 per cent of India's total goods exports, 6.22 per cent of its imports, and 10.73 per cent of its total merchandise trade.
According to exporters, the agreement is important as India's merchandise exports to the US declined for the second consecutive month in October, falling by 8.58 per cent to USD 6.3 billion due to the hefty tariffs imposed by Washington.
