London, April 18: In a breakthrough, scientists have found an antibody, a monthly dose of which could halve the number of debilitating attacks of migraine on patients who have exhausted all other treatments.
The findings showed that people treated with erenumab were nearly three times more likely to have reduced their migraine days by 50 per cent or more than those treated with placebo.
Those treated with erenumab also had a greater average reduction in the number of days they had headaches and the number of days they needed to take drugs to stop the migraines.
"Our study found that erenumab reduced the average number of monthly migraine headaches by more than 50 percent for nearly a third of study participants. That reduction in migraine headache frequency can greatly improve a person's quality of life," said Uwe Reuter from The Charite - University Medicine Berlin in Germany.
Erenumab is a monoclonal antibody that blocks pain signals by targeting a receptor for calcitonin gene-related peptide (CGRP).
This peptide transmits migraine pain signals. Erenumab occupies the nerves to which CGRP would usually bind.
"Our results show that people who thought their migraines were difficult to prevent may actually have hope of finding pain relief," Reuter added.
The preliminary results will be presented at the forthcoming American Academy of Neurology's 70th Annual Meeting in Los Angeles.
For the study, 246 people who had episodic migraine were given injections of either 140 milligrams of erenumab or a placebo once a month for three months.
Of the participants, 39 per cent had been treated unsuccessfully with two other medications, 38 per cent with three medications and 23 per cent with four medications.
A total of 30 per cent of the people treated with erenumab had half the number of headaches compared to 14 per cent on placebo.
For those on erenumab, there was an average 1.6 times greater reduction in migraine days and a 1.7 times greater reduction in acute medication days compared to those on placebo.
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Sitharaman refutes false claims that 'One Nation One Election' will be implemented in next polls
Chennai, Apr 5 (PTI): Union Finance and Corporate Affairs Minister Nirmala Sitharaman on Saturday dismissed the false propaganda surrounding the 'One Nation, One Election' concept, clarifying that it will not be implemented in the upcoming elections.
Speaking at an event near here, she noted that around Rs 1 lakh crore was spent during the 2024 Lok Sabha elections, and such a massive expenditure could be saved through simultaneous elections.
"If simultaneous elections are held for electing the members of Parliament and Assembly, about 1.5 per cent growth will be added to the country's GDP. In value terms, Rs 4.50 lakh crore will get added to the economy. This is a black and white example of One Nation One Election' concept", she said.
Sitharaman accused certain parties of "spreading a false campaign" on the 'One Nation One Election' initiative, blindly opposing it.
She clarified that simultaneous polls are planned to take place only after 2034 and the groundwork is being laid now for the then President to give his assent.
"This concept was widely discussed on several occasions. It was not something introduced by the Prime Minister Narendra Modi. This' One Nation One Election' was in existence till the 1960s. Instead of blindly opposing it, if it has been supported considering its benefit, the 'One Nation One Election' concept will make the country move forward," the union minister remarked.
Sitharaman claimed that the late DMK Patriarch M Karunanidhi had supported the 'One Nation One Election' concept, but his son and the current Chief Minister (M K Stalin) is not following in his father's footsteps and instead opposing it.
Sitharaman reiterated that the 'One Nation One Election' concept was not someone's "pet" project, but has been planned considering the welfare of the country.
In her about 30 minute speech, the Union Minister clarified that simultaneous polls refers to conduct of Parliamentary and Assembly polls and not local body elections.
"There has been talk that simultaneous polls referring to elections will be conducted even at that Municipality level. It is not. It only pertains to the conduct of Parliamentary and Assembly polls together" she said.
She recalled that in the 1961-1970s three elections were conducted within 10 years in five states, including Kerala, Uttar Pradesh, Punjab, Bihar and West Bengal.
Again, in the 1971 to 1980s, four elections were conducted in more than 14 States within 10 years.
Drumming up support for ONOE, Sitharaman said frequent conduct of Parliamentary and Assembly polls disrupts public welfare administration and affects developmental activities when the Model Code of Conduct is enforced.
"For example, even if an ambulance has to pass through a vital road, if the road has been laid but was not inaugurated due to implementation of model code of conduct, in view of elections, it gets affected," she said.
She clarified that she was not opposed to the implementation of Model Code of Conduct (MCC) but at the same time, a project gets stalled and one has to wait until the MCC is lifted.
Another important aspect of holding simultaneous polls is that nearly Rs 12,000 crore would be saved to the exchequer, she said and added that such a huge sum can be used for various people welfare schemes instead of spending in elections.
"A Parliamentary Standing Committee comprising MPs from all the parties participated in a discussion on simultaneous polls and recommended it and again in 2018, Niti Ayog suggested conducting One Nation, One Election concept," she said.
In 2019, another all party meeting was convened on holding One Nation, One Election in which out of 19 political parties, 16 of them approved it while CPM, RSP and AIMIM from Hyderabad opposed it.
Sitharaman also referred to deployment of para-military forces as in the 2019 elections, several lakhs of personnel were involved in poll related activities instead of carrying out their regular work while 25 lakh election administrative officials participated in the conduct of the polls in 12 lakh booths.
With the implementation of One Nation, One Election, voter percentage would also increase in states, she added.
