London, April 18: In a breakthrough, scientists have found an antibody, a monthly dose of which could halve the number of debilitating attacks of migraine on patients who have exhausted all other treatments.
The findings showed that people treated with erenumab were nearly three times more likely to have reduced their migraine days by 50 per cent or more than those treated with placebo.
Those treated with erenumab also had a greater average reduction in the number of days they had headaches and the number of days they needed to take drugs to stop the migraines.
"Our study found that erenumab reduced the average number of monthly migraine headaches by more than 50 percent for nearly a third of study participants. That reduction in migraine headache frequency can greatly improve a person's quality of life," said Uwe Reuter from The Charite - University Medicine Berlin in Germany.
Erenumab is a monoclonal antibody that blocks pain signals by targeting a receptor for calcitonin gene-related peptide (CGRP).
This peptide transmits migraine pain signals. Erenumab occupies the nerves to which CGRP would usually bind.
"Our results show that people who thought their migraines were difficult to prevent may actually have hope of finding pain relief," Reuter added.
The preliminary results will be presented at the forthcoming American Academy of Neurology's 70th Annual Meeting in Los Angeles.
For the study, 246 people who had episodic migraine were given injections of either 140 milligrams of erenumab or a placebo once a month for three months.
Of the participants, 39 per cent had been treated unsuccessfully with two other medications, 38 per cent with three medications and 23 per cent with four medications.
A total of 30 per cent of the people treated with erenumab had half the number of headaches compared to 14 per cent on placebo.
For those on erenumab, there was an average 1.6 times greater reduction in migraine days and a 1.7 times greater reduction in acute medication days compared to those on placebo.
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Mangaluru airport issues advisory to passengers, heightens security measures
Mangaluru: In response to recent cross-border attacks by Pakistan and rising tensions along the international boundary, the Bureau of Civil Aviation Security has directed airports across India to enhance security protocols. As part of this nationwide alert, Mangaluru International Airport has intensified surveillance, and introduced secondary ladder point checks (LPSC).
Explaining about the new protocol, Jaideep Shenoy, Public Relations Officer at Mangaluru International Airport, said that the secondary ladder point security check involves a second round of frisking. Passengers will first undergo standard checks by the CISF at the security checkpoint. Before boarding the aircraft, either via a boarding bridge or a bus, they will be subjected to an additional frisking by airline staff at the gate. Shenoy emphasized that the LPSC is a standard security measure implemented at all airports.
He also urged travelers to stay updated by checking the airport’s official social media channels for accurate and timely information.
In light of circulating reports regarding restrictions on visitor entry, Shenoy clarified that the entry of visitors into the terminal has always been restricted. Visitors may accompany passengers up to the departure gates or receive them at the arrival gates, as per existing rules.
In an advisory issued on Friday, Mangaluru International Airport urged passengers to arrive well in advance of their scheduled departures to accommodate extended security checks, and to cooperate with airport and security personnel.
The airport authorities also urged people not to share any unverified information.
#MangaluruAirport is fully operational, with your safety and comfort as our top priority. Stay informed and plan ahead to ensure a smooth journey.
— Mangaluru Airport (@mlrairport) May 9, 2025
Here’s everything you need to know before you fly, from security guidelines to handy dos and don’ts.
Plan ahead, stay informed, and… pic.twitter.com/clJTKPrlRT
