London, April 18: In a breakthrough, scientists have found an antibody, a monthly dose of which could halve the number of debilitating attacks of migraine on patients who have exhausted all other treatments.
The findings showed that people treated with erenumab were nearly three times more likely to have reduced their migraine days by 50 per cent or more than those treated with placebo.
Those treated with erenumab also had a greater average reduction in the number of days they had headaches and the number of days they needed to take drugs to stop the migraines.
"Our study found that erenumab reduced the average number of monthly migraine headaches by more than 50 percent for nearly a third of study participants. That reduction in migraine headache frequency can greatly improve a person's quality of life," said Uwe Reuter from The Charite - University Medicine Berlin in Germany.
Erenumab is a monoclonal antibody that blocks pain signals by targeting a receptor for calcitonin gene-related peptide (CGRP).
This peptide transmits migraine pain signals. Erenumab occupies the nerves to which CGRP would usually bind.
"Our results show that people who thought their migraines were difficult to prevent may actually have hope of finding pain relief," Reuter added.
The preliminary results will be presented at the forthcoming American Academy of Neurology's 70th Annual Meeting in Los Angeles.
For the study, 246 people who had episodic migraine were given injections of either 140 milligrams of erenumab or a placebo once a month for three months.
Of the participants, 39 per cent had been treated unsuccessfully with two other medications, 38 per cent with three medications and 23 per cent with four medications.
A total of 30 per cent of the people treated with erenumab had half the number of headaches compared to 14 per cent on placebo.
For those on erenumab, there was an average 1.6 times greater reduction in migraine days and a 1.7 times greater reduction in acute medication days compared to those on placebo.
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Congress to have massive organisational reshuffle: KC Venugopal
Ahmedabad, Apr 8 (PTI): The Congress is going to have a "massive organisational reshuffle", AICC general secretary K C Venugopal said on Tuesday as the party's top leaders met here and vowed to embark on the "path of social justice" espoused by Sardar Patel.
Briefing reporters after the extended Congress Working Committee meeting at the Sardar Vallabhbhai Patel National Memorial here, Venugopal noted that the Congress has dedicated this year to a complete restructuring of the party organisation and the issue was discussed at length at the meeting.
"We are going to have a massive organisational reshuffle, and there will be guidelines for the same. Our general secretaries and in-charges are on it," he said.
Venugopal also stressed that measures to empower the party's district unit chiefs will be rolled out soon.
"We have already decided on that issue, empowering the DCC presidents and duties and powers of the DCCs has been discussed in various forums, already general secretaries and in-charges have approved the proposals and we are going to roll out that proposal in the near future," he said while replying to queries.
Venugopal said the Extended CWC passed a resolution that "our party will walk on the path showed to us by Sardar Patel ji".
"He stood up against the oppression of the British, fighting for the rights of workers and farmers. He rejected communal forces after Bapu’s assassination. He fought for an India where everyone had fundamental rights and freedoms.
"Today, as we embark on the path of social justice, our Nyay Path follows the same principles laid down by Sardar Patel," he said.
In his opening address at the meeting, Congress president Mallikarjun Kharge also asserted the party's claim to Sardar Patel's legacy and accused the BJP and RSS of trying to usurp it under a "well-planned conspiracy" against national heroes.
Kharge stressed that the Congress is taking forward the legacy of Mahatma Gandhi and Patel.
"Sardar Patel Saheb lives in our hearts, lives in our thoughts. We are taking his legacy forward. We have organised this CWC meeting in Ahmedabad at Sardar Patel Museum with this thought in mind. We pay our heartfelt tributes to him," he said.
Earlier in the day, AICC general secretary Sachin Pilot told reporters that the Congress intends to create more empowered district units with their presidents having enhanced accountability, responsibility and political strength.
He said that the Congress would fight the upcoming elections with strength and expressed confidence that the Congress and its supporting ideologies would come together to give the BJP and the NDA a tough challenge.
Briefing reporters outside the venue, Pilot said, "The intention of the Congress president and the Leader of Opposition is to create a more empowered district unit."
"The accountability, the responsibility and the political strength that we have thus given to the district presidents is set to be enhanced," he stressed.
The final outcome will be decided after the convention on Wednesday but the intention of the Congress is to make the District Pradesh Congress (DCC) presidents more empowered than before, the former Union minister said, adding the move is aimed at expanding the party's reach in villages, divisions and booths.
"The year 2025 is the year of the organisation to strengthen our workers, expand our party ideology and to make sure that the Congress reaches out in a mass contact programme through padyatras and door-to-door programmes," he said.
The party wants to send a clear message not just to its opponents but to its supporters and workers that the Congress will not step back and fight aggressively both within Parliament and outside, and make sure it wins the next political challenge, Pilot said.
"Elections are fought to be won, the next few elections we will fight with strength and I am supremely confident that the Congress and its supporting ideologies will come together to give the BJP and the NDA a tough challenge," Pilot said.
He said the resolution passed at the end of the session on April 9 will be named 'Nyay Path'.
"Tomorrow' session will write a new chapter in history," he said
The grand old party has announced that the Ahmedabad Session will be themed "Nyaypath: Sankalp, Samarpan aur Sangharsh", with more than 1,700 elected and co-opted AICC members attending the main conclave on April 9 on the banks of the Sabarmati river between the Sabarmati Ashram and Kochrab Ashram.
