London, April 23: Scientists have developed a new technique to bind proteins to nanoparticles that can help make drugs "smarter" and more effective at reaching their target.
The new technique decorates gold nanoparticles with a protein of choice so that they can be used to tailor drug to more accurately target an area on the body, such as a cancer tumour.
Gold nanoparticles are spheres made of gold atoms having a diameter of only few billionths of a metre which can be coated with a biological protein and combined with drugs to enable the treatment to travel through the body and reach the affected area.
"Gold nanoparticles are a vital tool in new drug development and drug delivery systems. We have unlocked the key to binding proteins and molecules so that those drugs will be more effective," said Enrico Ferrari, a nanobiotechnologist from Britain's University of Lincoln.
Until now, the proteins used to coat the nanoparticles had to be mixed together with particles which do not have the ability to control the way they bind, possibly making the drug less effective.
However, the new method, published in the journal Nature Communications, enables pharmacologists to place the proteins onto the gold nanoparticles layer by layer in a specific order.
This maintains the integrity of the protein so that the drug is more effective, opening up possibilities for the development of nanomedicine.
"This method might help to design nanomedicines that do not need extensive chemical modification of a protein drug or a nano-carrier and therefore can be developed more easily and faster," Ferrari added.
Researchers took fragments of proteins from bacteria and flatworms, which when fused together were effective at binding to the gold nanoparticle surface and able to form stable bonds to any other protein.
By mixing this fusion protein with gold nanoparticles, it permanently binds to the gold surface while also being able to stably bind a target protein.
The novel method could also potentially be applied to biosensors and diagnostic kits that use gold, such as those used in clinical settings to identify ongoing infections in patients' blood, the researchers said.
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Congress holds ‘Jai Hind Tiranga Yatra’ in Bengaluru in support of armed forces
Bengaluru (PTI): A large crowd gathered at KR Circle in Bengaluru on Friday as the ruling Congress in Karnataka organised the ‘Jai Hind Tiranga Yatra’ to express solidarity with the Indian armed forces that carried out Operation Sindoor to avenge the Pahalgam terror attack.
The Indian tricolour fluttered at the venue amid loud chants of ‘Jai Hind-Jai Bharat-Jai Tiranga’, ‘Bharat Zindabad’ (Long Live India), ‘Bharat Mata Ki Jai’ (Victory to India), and ‘Our soldiers are our pride’.
Chief Minister Siddaramaiah, his deputy D K Shivakumar, and several senior ministers participated in the march, which began at KR Circle and concluded at M Chinnaswamy Stadium.
Shivakumar said the event was organised to express solidarity with the soldiers guarding India’s borders.
The Congress state president appealed to the public to join the march wholeheartedly as a mark of respect for the defence forces.
Speaking to reporters later, Shivakumar said the Congress organised the ‘Jai Hind Tiranga Yatra’, and people from all walks of life—including students, government employees, and members of various organisations and institutions—were invited to take part.
"Soldiers are our national pride. We want to salute them. We stand in solidarity with them to convey that the entire country is behind them," he said, expressing happiness over the huge turnout despite the short notice.
