London, April 23: Scientists have developed a new technique to bind proteins to nanoparticles that can help make drugs "smarter" and more effective at reaching their target.
The new technique decorates gold nanoparticles with a protein of choice so that they can be used to tailor drug to more accurately target an area on the body, such as a cancer tumour.
Gold nanoparticles are spheres made of gold atoms having a diameter of only few billionths of a metre which can be coated with a biological protein and combined with drugs to enable the treatment to travel through the body and reach the affected area.
"Gold nanoparticles are a vital tool in new drug development and drug delivery systems. We have unlocked the key to binding proteins and molecules so that those drugs will be more effective," said Enrico Ferrari, a nanobiotechnologist from Britain's University of Lincoln.
Until now, the proteins used to coat the nanoparticles had to be mixed together with particles which do not have the ability to control the way they bind, possibly making the drug less effective.
However, the new method, published in the journal Nature Communications, enables pharmacologists to place the proteins onto the gold nanoparticles layer by layer in a specific order.
This maintains the integrity of the protein so that the drug is more effective, opening up possibilities for the development of nanomedicine.
"This method might help to design nanomedicines that do not need extensive chemical modification of a protein drug or a nano-carrier and therefore can be developed more easily and faster," Ferrari added.
Researchers took fragments of proteins from bacteria and flatworms, which when fused together were effective at binding to the gold nanoparticle surface and able to form stable bonds to any other protein.
By mixing this fusion protein with gold nanoparticles, it permanently binds to the gold surface while also being able to stably bind a target protein.
The novel method could also potentially be applied to biosensors and diagnostic kits that use gold, such as those used in clinical settings to identify ongoing infections in patients' blood, the researchers said.
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8 children between ages of 1 and 14 dead after mass shooting in Louisiana, police say
Shreveport(US) (AP): A gunman in Louisiana killed eight children in shootings at two different homes early Sunday in the nation's deadliest mass shooting in more than two years, police in Shreveport said.
The victims ranged in age from one to about 14 years old, said Shreveport police spokesperson Chris Bordelon. A total of 10 were shot and some of the children were related to the suspect, Bordelon said.
The gunman later died after a chase with officers who fired at the suspect, Bordelon said. The suspect stole a car while leaving the scene of the shootings and was followed by police, according to Bordelon.
Police did not release the name of the suspect but did say he was an adult male. The shootings were the result of a “domestic disturbance,” Bordelon said.
Officials said they were still gathering details at the crime scenes south of downtown Shreveport — the two homes and a third location.
“This is an extensive scene unlike anything most of us have ever seen,” he said.
It was the deadliest mass shooting in the US since eight people were killed in a Chicago suburb in January 2024, according to a database maintained by The Associated Press and USA Today in partnership with Northeastern University.
At a news conference outside the residence where one of the shootings occurred, officials appeared stunned, requesting patience and prayers from the community as they sorted through multiple crime scenes.
“I just don't know what to say, my heart is just taken aback,” Shreveport Police Chief Wayne Smith said. “I cannot begin to imagine how such an event could occur.”
“This is a tragic situation — maybe the worst tragic situation we've ever had,” said Tom Arceneaux, mayor of the city in northwestern Louisiana with about 180,000 residents. “It's a terrible morning.”
Louisiana State Police say their detectives have been asked by Shreveport police to investigate. In a statement, state police say no officers were harmed in the shooting that involved an officer after a police pursuit into Bossier City on Sunday morning.
State police are asking anyone with pictures, video or information to share it with state police detectives.
Louisiana Gov Jeff Landry said in a statement that he and his wife were heartbroken. “We're deeply grateful to the law enforcement officers and first responders working tirelessly on the scene,” he added.
