London, April 23: Scientists have developed a new technique to bind proteins to nanoparticles that can help make drugs "smarter" and more effective at reaching their target.
The new technique decorates gold nanoparticles with a protein of choice so that they can be used to tailor drug to more accurately target an area on the body, such as a cancer tumour.
Gold nanoparticles are spheres made of gold atoms having a diameter of only few billionths of a metre which can be coated with a biological protein and combined with drugs to enable the treatment to travel through the body and reach the affected area.
"Gold nanoparticles are a vital tool in new drug development and drug delivery systems. We have unlocked the key to binding proteins and molecules so that those drugs will be more effective," said Enrico Ferrari, a nanobiotechnologist from Britain's University of Lincoln.
Until now, the proteins used to coat the nanoparticles had to be mixed together with particles which do not have the ability to control the way they bind, possibly making the drug less effective.
However, the new method, published in the journal Nature Communications, enables pharmacologists to place the proteins onto the gold nanoparticles layer by layer in a specific order.
This maintains the integrity of the protein so that the drug is more effective, opening up possibilities for the development of nanomedicine.
"This method might help to design nanomedicines that do not need extensive chemical modification of a protein drug or a nano-carrier and therefore can be developed more easily and faster," Ferrari added.
Researchers took fragments of proteins from bacteria and flatworms, which when fused together were effective at binding to the gold nanoparticle surface and able to form stable bonds to any other protein.
By mixing this fusion protein with gold nanoparticles, it permanently binds to the gold surface while also being able to stably bind a target protein.
The novel method could also potentially be applied to biosensors and diagnostic kits that use gold, such as those used in clinical settings to identify ongoing infections in patients' blood, the researchers said.
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Waqf Bill voting: BJD leaves it to conscience of RS MPs, no party whip
Bhubaneswar, Apr 3 (PTI): A day after announcing that the Biju Janata Dal would oppose the Waqf (Amendment) Bill in Parliament, the party on Thursday said it has not issued any whip to its MPs about voting on the matter in Rajya Sabha.
The MPs will vote according to their conscience, BJD national spokesperson Sasmit Patra said.
The BJD has seven members in the Rajya Sabha, while no member in the Lok Sabha.
"The Biju Janata Dal has always upheld the principles of secularism and inclusivity, ensuring the rights of all communities. We deeply respect the diverse sentiments expressed by different sections of the Minority communities regarding the Waqf (Amendment) Bill, 2024," Patra said in a post on X.
"Our Party, having taken these views into careful consideration, has entrusted our Hon’ble Members in the Rajya Sabha with the responsibility of exercising their conscience in the best interest of justice, harmony and the rights of all communities, should the Bill come up for voting. There is no Party Whip," the post read.
Patra on Wednesday said that the BJD was opposed to some of the provisions in the Waqf Bill, 2024, as its suggestion for changes in the original draft was not accepted.
The Lok Sabha early Thursday passed the contentious Waqf (Amendment) Bill, after over a 12-hour debate, which saw the ruling NDA defending the legislation as beneficial for minorities, while the opposition described it as "anti-Muslim".
The Bill was passed after all amendments moved by the opposition members were rejected by voice votes. It was passed after a division of votes -- 288 in favour and 232 against.
The Biju Janata Dal has always upheld the principles of secularism and inclusivity, ensuring the rights of all communities. We deeply respect the diverse sentiments expressed by different sections of the Minority communities regarding the Waqf (Amendment) Bill, 2024. Our Party,…
— ଡ଼ଃ ସସ୍ମିତ ପାତ୍ର I Dr. Sasmit Patra (@sasmitpatra) April 3, 2025
