Researchers suggest Vitamin D therapy can tackle diabetes, cancer
New York, May 13: Enhanced activation of Vitamin D by protecting beta cells may be a potential new approach for treating diabetes as well as other diseases, including cancer, researchers have suggested.
When beta cells -- the cells in the pancreas that produce, store and release the hormone insulin -- become dysfunctional, the body cannot make insulin to control blood sugar (glucose) and levels of glucose can rise to dangerous and even fatal levels.
The researchers found that Vitamin D in cells and mouse models can be beneficial in treating these damaged beta cells.
They also provided new insights about gene regulation that could be applied to developing treatments for other diseases, including cancer.
"We know that diabetes is a disease caused by inflammation. We identified the Vitamin D receptor as an important modulator of both inflammation and beta cell survival," said Ronald Evans, from Salk Institute for Biological Studies in California, US.
Using beta cells created from embryonic stem cells, the team was able to identify a compound -- iBRD9 -- that appeared to enhance the activation of the Vitamin D receptor when it was combined with Vitamin D to improve the survival of beta cells.
In the paper, published in the journal Cell, the team conducted a screening test to look for compounds that improved the survival of beta cells in a dish. They then tested the combination in a mouse model of diabetes and showed that it could bring glucose back to normal levels in the animals.
Combining the new compound with vitamin D allowed certain protective genes to be expressed at much higher levels than they are in diseased cells.
"Activating the vitamin D receptor can trigger the anti-inflammatory function of genes to help cells survive under stressed conditions," explained Michael Downes, from the institute.
The researchers noted that although the new compound did not appear to cause any side effects in the mice, further testing is needed before clinical trials can begin.
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Agra man arrested for harassing, touching inappropriately Czech tourist visiting Taj Mahal
Agra, Apr 6 (PTI): A man was arrested for allegedly harassing and touching inappropriately a tourist from the Czech Republic visiting the Taj Mahal, police said on Sunday.
The alleged incident occurred on April 3 and the arrest was made after a thorough investigation, they said.
In a written complaint at the Tourist police station, the woman alleged that she was "touched inappropriately and harassed" while walking along the Shamshan Ghat Road around 1 pm, they added.
The police registered a case and began a probe, deploying multiple teams to nab the accused.
Assistant Commissioner of Police (Taj Security) Syed Areeb Ahmed said, "A case was registered on the complaint of the foreign woman. Several teams were deployed to search for the accused. (Footage from) several CCTV cameras covering the area was scanned. After investigation, the accused Karan Rathore was arrested on Sunday."
The woman has identified Rathore as the accused and he has been taken into custody, the officer said.
