Scientists offer hope for genetically determined obesity
London, June 3: Unable to maintain weight loss due to your genetic predisposition to obesity? Take heart, an injectable drug widely used to lower blood sugar levels can help you fight overweight, suggest a study.
Around two to six per cent of all people with obesity develop obesity already in early childhood because they are genetically programmed to do so.
Obesity-causal mutations in one of their "appetite genes" gives them a strong genetic predisposition for developing obesity, also called monogenic obesity. Their experience of hunger is over-ruling and their feeling of satiety limited.
Researchers discovered that this group of people with obesity can lose weight with the help of the medicine liraglutide -- a modified form of the appetite-inhibiting hormone GLP-1 naturally secreted from the intestine when we eat.
"The appetite-inhibiting drug liraglutide has a positive effect on them. They feel less hungry and lose six per cent of their body weight within four months," said lead author Signe Sorensen Torekov, associate professor at the University of Copenhagen in Denmark.
In the study, published in the journal Cell Metabolism, the team have examined a small group with obesity caused by pathogenic mutations in the so-called MC4R gene and those with obesity without the mutations.
Both groups were treated with the medicine for four months; no changes were made to their diet and level of exercise in this period.
The individuals with this most common form of monogenic obesity lost 7 kg of their body weight compared to 6 kg for the people with common obesity.
Medicine acting as an analogue to our natural GLP-1 hormone is already available, as it has been approved by both the US Food Drug Association and European Medicines Agency for the treatment of obesity and Type 2 diabetes.
The study thus makes it possible to treat the most common form of genetically caused obesity, where patients respond poorly to existing treatments, the researchers noted.
As MC4R mutations cause obesity already in early childhood, the researchers hope the results can pave the way for new studies on young people in the future.
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Protest breaks out in Imphal valley after three bodies found in Jiribam
Imphal (PTI): Hundreds of people protested in different parts of Imphal valley on Saturday after three bodies suspected to be of six persons missing were found from Jiribam district.
The protesters mostly women blocked the main roads in Kwakeithel area in Imphal West district, Sagolband Tera in Imphal West district by burning tyres to prevent vehicular movement, police said.
At Khwairamband market, the main market of Manipur, women vendors staged a protest rally against the killing even as huge security forces were deployed in Imphal, the police said.
As news of the recovery of three bodies spread, business establishments and markets closed down.
Locals also came out on the streets at Ningthoukhong in Bishnupur district and Lamlong in Imphal East district to stage protests against the killing.
The state government has already declared a holiday for schools and colleges on Saturday.
Three bodies of a woman and two children suspected to be of six persons missing from Jiribam district were found near the confluence of Jiri river and Barak river along Manipur-Assam border on Friday night, officials said on Saturday.
The bodies were brought to Assam's Silchar Medical College Hospital (SMCH) on Friday night and kept at the hospital's morgue for postmortem.
Three women and three children who lived in a relief camp have been missing since a gunfight between security forces and militants in Jiribam district on Monday, with Metei organisations alleging that they were kidnapped by the retreating militants. Police said a search was underway for them.
More than 200 people have been killed and thousands rendered homeless in ethnic clashes between Imphal Valley-based Meiteis and adjoining hills-based Kuki-Zo groups since May last year.
Ethnically diverse Jiribam, which was largely untouched by the clashes in Imphal Valley and the adjoining hills, witnessed violence after the mutilated body of a farmer was found in a field in June this year.
