Opener Ruturaj Gaikwad cracked a blistering 92 off 50 balls to power Chennai Super Kings to 178/7 after being asked to bat.
In reply, the Titans reached the target in 19.2 overs.
Shubman Gill was the top scorer for the Titans, scoring a 36-ball 63.
Earlier, Gaikwad smashed nine sixes even though wickets fell at regular interval at the other end.
For the Titans, spinner Rashid Khan (2/26) and pacers Mohammed Shami (2/29) and Alzarri Joseph (2/33) picked two wickets each.
Brief Scores:
Gujarat Titans 182 for 5 in 19.2 overs (Shubman Gill 63; Rajvardhan Hangargekar 3/36).
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Mumbai (PTI): Ryan Rickelton's whirlwind unbeaten ton was overshadowed by Heinrich Klaasen's unbeaten 65 as Sunrisers Hyderabad defeated Mumbai Indians by six wickets in an IPL match here on Wednesday.
Chasing an imposing 244-run target, Travis Head (76 off 30) and Abhishek Sharma (45 off 24) shared 129 runs for the opening wicket to set the platform for SRH.
Klaasen (65 not out off 30 balls) then displayed his all-round hitting abilities to guide SRH home with the help of Nitish Kumar Reddy (21) and Salil Arora (30 not out off 10) in 18.4 overs.
Earlier, Rickelton's knock powered MI to 243 for five.
MI rode on a 93-run stand between Rickelton (123 not out off 55 balls) and Will Jacks (46 off 22) in 7.1 overs for the opening stand to power the side.
MI skipper Hardik Pandya scored a valuable 31 off 15 balls before being dismissed.
Praful Hinge (2/54), Eshan Malinga (1/29), Sakib Hasan (1/39) and Nitish Kumar Reddy (1/31) were the wicket-takers for SRH.
Brief Scores:
Mumbai Indian: 243 for 5 in 20 overs (Ryan Rickelton 123 not out; Praful Hinge 2/54).
Sunrisers Hyderabad: 249 for 4 in 18.4 overs (Travis Head 76, Heinrich Klaasen 65 not out; AM Ghazanfar 2/51).
