Coronavirus: Dexamethasone proves first life-saving drug
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A cheap and widely available drug can help save the lives of patients seriously ill with coronavirus.
The low-dose steroid treatment dexamethasone is a breakthrough in the fight against the deadly virus, UK experts say.
The drug is part of the world's biggest trial testing existing treatments to see if they also work for coronavirus.
It cut the risk of death by a third for patients on ventilators. For those on oxygen, it cut deaths by a fifth.
Had the drug had been used to treat patients in the UK from the start of the pandemic, up to 5,000 lives could have been saved, researchers say.
And it could be of huge benefit in poorer countries with high numbers of Covid-19 patients.
The UK government has 200,000 courses of the drug in its stockpile and says the NHS will make dexamethasone available to patients.
About 19 out of 20 patients with coronavirus recover without being admitted to the hospital.
Of those who are admitted, most also recover but some may need oxygen or mechanical ventilation.
And these are the high-risk patients' dexamethasone appears to help.
The drug is already used to reduce inflammation in a range of other conditions.
And it appears to help stop some of the damage that can happen when the body's immune system goes into overdrive as it tries to fight off coronavirus.
This over-reaction, a cytokine storm, can be deadly.
In the trial, led by a team from Oxford University, about 2,000 hospital patients were given dexamethasone and compared with more than 4,000 who were not.
For patients on ventilators, it cut the risk of death from 40% to 28%.
For patients needing oxygen, it cut the risk of death from 25% to 20%.
Chief investigator Prof Peter Horby said: "This is the only drug so far that has been shown to reduce mortality - and it reduces it significantly. It's a breakthrough."
Lead researcher Prof Martin Landray said the findings suggested one life could be saved for:
- every eight patients on a ventilator
- every 20-25 treated with oxygen
"There is a clear, clear benefit," he said.
"The treatment is up to 10 days of dexamethasone and it costs about £5 per patient.
"So essentially it costs £35 to save a life.
"This is a drug that is globally available."
When appropriate, hospital patients should now be given it without delay, Prof Landray said.
But people should not go out and buy it to take at home.
Dexamethasone does not appear to help people with milder symptoms of coronavirus who do not need help with their breathing.
The Recovery Trial, running since March, also looked at the malaria drug hydroxychloroquine, which has subsequently been ditched amid concerns it increases fatalities and heart problems.
The antiviral drug remdesivir, meanwhile, which appears to shorten recovery time for people with coronavirus, is already being made available on the NHS.
The first drug proven to cut deaths from Covid-19 is not some new, expensive medicine but an old, cheap-as-chips steroid.
That is something to celebrate because it means patients across the world could benefit immediately.
And that is why the top-line results of this trial have been rushed out - because the implications are so huge globally.
Dexamethasone has been used since the early 1960s to treat a wide range of conditions, such as rheumatoid arthritis and asthma.
Half of all COVID patients who require a ventilator do not survive, so cutting that risk by a third would have a huge impact.
The drug is given intravenously in intensive care and tablet form for less seriously ill patients.
So far, the only other drug proven to benefit COVID patients is remdesivir, which has been used for Ebola.
That has been shown to reduce the duration of coronavirus symptoms from 15 days to 11.
But the evidence was not strong enough to show whether it reduced mortality.
Unlike dexamethasone, remdesivir is a new drug with limited supplies and a price has yet to be announced.
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Ballari clash: Sriramulu, Janardhana Reddy hold press meet; statue unveiling postponed
Ballari: Former minister B Sriramulu and Gangavathi MLA Gali Janardhana Reddy addressed a joint press conference on Friday, a day after a violent clash broke out between rival Reddy groups over the installation of banners ahead of the Valmiki statue unveiling programme in the city.
Speaking to reporters, Sriramulu said the death of Rajasekhar Reddy, who was killed by a gunshot during the clash, was painful. He said he and his party would stand by the victim’s family and extend support to them. Alleging that Ballari MLA Nara Bharath Reddy was responsible for the incident, Sriramulu demanded legal action against him and called for a thorough probe to establish whose bullet caused Rajasekhar Reddy’s death.
Sriramulu further alleged that the clash was premeditated, claiming that a group had come near their residence with petrol-filled beer bottles and stones, allegedly with the intention of attacking them. He also alleged that there was an attempt to assault Janardhana Reddy.
Janardhana Reddy, addressing the media, said the incident had made him fear for his life. He alleged that there was an attempt to kill him and held Bharath Reddy responsible for the violence. Former minister Somasekhar Reddy, BJP Ballari district leaders and party workers were also present at the press meet.
The clash occurred on Thursday night in the Havambhavi area when rival groups confronted each other over putting up banners for the Valmiki statue unveiling scheduled for January 3. During the violence, a Congress worker was shot dead. Police have registered four separate cases in connection with the incident, including one taken up suo motu.
Responding to the allegations, Ballari MLA Bharath Reddy said the party was mourning the loss of its worker, Rajasekhar Reddy, whom he described as a close associate. He accused Janardhana Reddy of trying to divert attention from illegal mining issues and said the death had cast a shadow over the planned celebrations. He announced that the Valmiki statue unveiling programme had been postponed due to the prevailing atmosphere of grief.
Meanwhile, Ballari Rural MLA B Nagendra confirmed that the statue unveiling event had been temporarily deferred following the clash and on the advice of the Chief Minister. He said the programme would be held on a later date under the leadership of the Chief Minister and senior ministers. Nagendra also criticised Janardhana Reddy, saying there was no place for what he described as a “Republic of Ballari” mindset under the present administration, and asserted that the government would not allow any form of intimidation or lawlessness.
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