Washington: The highly contagious Delta variant of the coronavirus is the "greatest threat" to America's attempt to eradicate the COVID-19 pandemic, White House Chief Medical Advisor Dr Anthony Fauci has warned.

Speaking at a White House briefing on COVID-19 on Tuesday, Fauci said the variant, which was first identified in India, now makes up more than 20 per cent of all new cases in the US, a significant increase from nearly 10 per cent two weeks ago.

"Similar to the situation in the UK, the Delta variant is currently the greatest threat in the US to our attempt to eliminate COVID-19, Fauci told reporters during a virtual news conference here.

However, the good news is that the US vaccines are effective against the Delta variant, said Fauci, the head of the National Institutes of Allergy and Infectious Diseases (NIAID).

Conclusion, we have the tools, so let's use them and crush the outbreak, he asserted.

The Delta variant recently became the dominant strain in the UK, surpassing the Alpha variant first discovered in the country. The strain makes up more than 90 per cent of new cases and delayed the UK's scheduled reopening.

The transmissibility of Delta variant is unquestionably greater than the wild type SARS-CoV2 as well as the Alpha variant, Fauci said, adding that it is associated with increased disease severity as reflected by hospitalisation risk compared to the Alpha variant.

The Imperial College of London did a study in over 100,000 homes and found that youth were driving the UK's surge with a five-fold higher positivity among children aged 5-12 and young adults 18-24 years versus people older than 65 years old, he said.

"Look at what is happening in the United States. We have seen, as was the case with B.1.1.7, we seem to be following the pattern with the Delta variant with a doubling time of about two weeks if you look from May 8 with 1.2 to 2.7 to 9.9 and as of a couple of days ago 20.6 per cent of the isolates are Delta, Fauci said.

He said the United States has tools to address the challenge.

The effectiveness of the vaccines, in this case, two weeks after the second dose of Pfizer BioNTech with 88 per cent effective against the Delta and 93 per cent effective against the Alpha when you are dealing with symptomatic disease, he said.

Rochelle Paula Walensky, the director of the Centers for Disease Control and Prevention, said that CDC continues to follow the prevalence of the Delta variant of COVID-19.

In the last two weeks, the prevalence of cases resulting from the Delta variant has doubled to just over 20 per cent. This variant represents nearly half of all infections, she said.

This is concerning but expected knowing what we do about how efficiently this variant spreads and by what we saw in the United Kingdom with this variant.

We know our vaccines work against this variant; however, this variant represents a set of mutations that could lead to future mutations that evade our vaccine, and that is why it is more important than ever to get vaccinated now to stop the chain of infection, the chain of mutations that could lead to a more dangerous variant, Walensky said.

The US Centers for Disease Control and Prevention has classified the Delta, a highly transmissible COVID-19 variant, as a "variant of concern."

"The B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), B.1.427 (Epsilon), B.1.429 (Epsilon), and B.1.617.2 (Delta) variants circulating in the United States are classified as variants of concern. To date, no variants of high consequence have been identified in the United States," the CDC said in a statement last week.

The World Health Organization classified the Delta variant as a variant of concern on May 10.

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Dubai (AP): The US and Israel launched a major attack on targets across Iran on Saturday, and US President Donald Trump called on the Iranian people to “take over your government” — an extraordinary appeal that suggested the allies could be seeking to end of the country's theocracy after decades of tensions.

The first strikes of the attack appeared to target the compound home to Iran's 86-year-old Supreme Leader Ayatollah Ali Khamenei in downtown Tehran. It wasn't immediately clear if he was there at the time. Smoke could be seen rising from the Iranian capital.

“For 47 years, the Iranian regime has chanted Death to America and waged an unending campaign of bloodshed and mass murder, targeting the United States, our troops and the innocent people in many, many countries,” Trump said in a video posted on social media that sought to justify the attacks. He urged Iranians to take cover during the strikes, but then: “When we are finished, take over your government. It will be yours to take.”

The attack quickly expanded beyond Iran. Iran's paramilitary Revolutionary Guard said it responded by launching a “first wave” of drones and missiles targeting Israel, where a nationwide warning was issued as the military said it bring down Iranian fire.

Meanwhile, Bahrain said that a missile attack targeted the US Navy's 5th Fleet headquarters in the island kingdom. Witnesses heard sirens and explosions in Kuwait, home to US Army Central. Explosions could be also be heard in Qatar.

Iraq and the United Arab Emirates closed their airspace, and sirens sounded in Jordan.

The Iranian-backed Houthis in Yemen, meanwhile, vowed to resume attacks on Red Sea shipping routes and on Israel, according to two senior Houthi officials. They spoke on condition of anonymity because there was no official announcement from the Houthi leadership.

Iran's Foreign Ministry issued a defiant statement, saying that the country “will not hesitate” in its response. In a statement posted on X, the ministry said: “The time has come to defend the homeland and confront the enemy's military assault.”

'Major combat operations'

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Trump said in the video that the US had begun “major combat operations in Iran" after the US assembled a vast fleet of fighter jets and warships in the region to try to pressure Iran into a deal over its nuclear programme.

Trump claimed in the video that Iran has continued to develop its nuclear programme and plans to develop missiles to reach US He acknowledged that there could be American casualties following Iran strikes, saying “that often happens in war.”

Iran has said it hasn't enriched since June, but it has blocked international inspectors from visiting the sites America bombed during a 12-day war then. Satellite photos analyzed by The Associated Press have shown new activity at two of those sites, suggesting Iran is trying to assess and potentially recover material there.

Iran currently has a self-imposed limit on its ballistic missile programme, limiting their range to 2,000 kilometers (1,240 miles). That puts all the Mideast and some of eastern Europe in their range. There is no public evidence of Iran seeking to have intercontinental ballistic missiles, though Washington has criticized its space programme as potentially allowing it to one day.

Tensions have soared in recent weeks as American warships moved into the region, and Trump said he wanted a deal to constrain Iran's nuclear programme. He saw an opportunity while the country is struggling at home with growing dissent following nationwide protests.

Iran had hoped to avert a war, but maintains it has the right to enrich uranium and does not want to discuss other issues, like its long-range missile programme or support for armed groups like Hamas and Hezbollah.

But Trump's statement indicated the US was striking for reasons far beyond the nuclear programme, listing grievances stretching back to the beginning of the Islamic Republic.

Prime Minister Benjamin Netanyahu of Israel — which considers Iran its archenemy — said the joint attack was to “remove an existential threat posed” by Iran.

“Our joint operation will create the conditions for the brave Iranian people to take their fate into their own hands,” Netanyahu said.

Targets in the Israeli campaign included Iran's military, symbols of government and intelligence targets, according to an official briefed on the operation, who spoke on condition of anonymity to discuss nonpublic information on the attack.

Iran retaliates

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Hours after the strikes, Iran's paramilitary Revolutionary Guard said it launched a “first wave” of drones and missiles targeting Israel. It had vowed to respond if attacked, including saying American military personnel and bases spread across the region would be targets.

Explosions rocked Israel as the country worked to intercept incoming Iranian missiles. There was no immediate word on any damage or casualties from the ongoing attack.

Several hospitals in Israel launched their emergency protocols, including moving patients and surgeries to underground facilities.

US embassies or consulates in Qatar, United Arab Emirates and Israel posted on social media that they told staffers to shelter in place and recommended all Americans “do the same until further notice.”

Strikes hit targets across Iran

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Iranian media reported strikes nationwide. Roads to Khamenei's compound in downtown Tehran had been shut down by authorities as other blasts rang out across the capital.

In Tehran, witnesses heard the first blast by Khamenei's office. Iranian state television later reported on the explosion, without offering a cause.

More explosions struck Iran's capital after Israel said it was attacking the country. Authorities have offered no casualty information from the strikes.