Highly effective coronavirus antibodies identified, may lead to passive COVID-19 vaccine
Berlin: Scientists have identified highly effective antibodies against the novel coronavirus, which they say can lead to the development of a passive vaccination for COVID-19.
Unlike in active vaccination, passive vaccination involves the administration of ready-made antibodies, which are degraded after some time.
However, the effect of a passive vaccination is almost immediate, whereas with an active vaccination it has to build up first, the researchers said.
The research, published in the journal Cell, also shows that some SARS-CoV-2 antibodies bind to tissue samples from various organs, which could potentially trigger undesired side effects.
The scientists at the German Center for Neurodegenerative Diseases (DZNE) and Charite - Universitatsmedizin Berlin isolated almost 600 different antibodies from the blood of individuals who had overcome COVID-19, the disease triggered by SARS-CoV-2.
By means of laboratory tests, they were able to narrow this number down to a few antibodies that were particularly effective at binding to the virus.
The researchers then produced these antibodies artificially using cell cultures.
The so-called neutralising antibodies bind to the virus, as crystallographic analysis reveals, and thus prevent the pathogen from entering cells and reproducing, they said.
In addition, virus recognition by antibodies helps immune cells to eliminate the pathogen. Studies in hamsters -- which, like humans, are susceptible to infection by SARS-CoV-2 -- confirmed the high efficacy of the selected antibodies.
If the antibodies were given after an infection, the hamsters developed mild disease symptoms at most. If the antibodies were applied preventively -- before infection -- the animals did not get sick, said Jakob Kreye, coordinator of the research project.
The researchers noted that treating infectious diseases with antibodies has a long history.
For COVID-19, this approach is also being investigated through the administration of plasma derived from the blood of recovered patients. With the plasma, antibodies of donors are transferred, they said.
"Ideally, the most effective antibody is produced in a controlled manner on an industrial scale and in constant quality. This is the goal we are pursuing," said Momsen Reincke, first author of the research.
Three of our antibodies are particularly promising for clinical development, explained Harald Pruss, a research group leader at the DZNE and also a senior physician at Charite Universitatsmedizin Berlin.
"Using these antibodies, we have started to develop a passive vaccination against SARS-CoV-2," Pruss said.
In addition to the treatment of patients, preventive protection of healthy individuals who have had contact with infected persons is also a potential application, the researchers said.
How long the protection lasts will have to be investigated in clinical studies, they said.
This is because, unlike in active vaccination, passive vaccination involves the administration of ready-made antibodies, which are degraded after some time, Pruss said. In general, the protection provided by a passive vaccination is less persistent than that provided by an active vaccination, the researchers said.
However, the effect of a passive vaccination is almost immediate, whereas with an active vaccination it has to build up first, they said.
It would be best if both options were available so that a flexible response could be made depending on the situation, Pruss added.
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Air India flight from Mumbai makes 'priority' landing in Bhopal after snag; return leg cancelled
Bhopal (PTI): A Bhopal-bound Air India flight from Mumbai carrying 175 persons on board made a “priority” landing here on Sunday due to a snag, an airport official said.
The aircraft landed safely at Bhopal airport at 3.20 pm, he said.
Consequently, the return leg of the flight from Bhopal to Mumbai, with 178 passengers booked, was cancelled, the official said.
AAI-run Bhopal airport said in a statement that Air India flight AI 633 “reported a technical issue to Air Traffic Control (ATC) during the flight from Mumbai to Bhopal”.
Immediately, all prescribed safety protocols were activated, and seamless coordination was ensured between ATC, airline ground operations, CISF and airpiort fire and rescue team of Bhopal airport, it said in a statement.
The flight, carrying 175 persons, including 166 passengers and nine crew members, landed safely at Bhopal airport at 3.20 pm, the airport operator said.
All necessary assistance and support were extended by the airport and airline teams as per the requirements of the flight crew, it said.
“Due to the technical issue, the aircraft was declared unserviceable, and as a precautionary measure, the return flight AI-634 (Bhopal to Mumbai) was cancelled by the airline to facilitate detailed inspection and rectification,” the statement said.
