Trio win Nobel Medicine Prize for work on cells, oxygen
Stockholm: US researchers William Kaelin and Gregg Semenza and Britain's Peter Ratcliffe on Monday shared the Nobel Medicine Prize for discoveries on how cells sense and adapt to oxygen availability, the Nobel Assembly said.
"They established the basis for our understanding of how oxygen levels affect cellular metabolism and physiological function," the jury said.
Their research has "paved the way for promising new strategies to fight anemia, cancer and many other diseases."
The jury said the trio had identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen, which is central to a large number of diseases.
"Intense ongoing efforts in academic laboratories and pharmaceutical companies are now focused on developing drugs that can interfere with different disease states by either activating, or blocking, the oxygen-sensing machinery," the jury said.
Kaelin works at the Howard Hughes Medical Institute in the US, while Semenza is director of the Vascular Research Program at the John Hopkins Institute for Cell Engineering.
Ratcliffe is director of clinical research at the Francis Crick Institute in London, and director of the Target Discovery Institute in Oxford.
The three will share the Nobel prize sum of nine million Swedish kronor (about USD 914,000).
They will receive their prize from King Carl XVI Gustaf at a formal ceremony in Stockholm on December 10, the anniversary of the 1896 death of scientist Alfred Nobel who created the prizes in his last will and testament.
Last year, the honour went to immunologists James Allison of the US and Tasuku Honjo of Japan, for figuring out how to release the immune system's brakes to allow it to attack cancer cells more efficiently.
The winners of this year's Physics Prize will be revealed on Tuesday, followed by the Chemistry Prize on Wednesday.
The Literature Prize will be announced on Thursday, with two laureates to be crowned after a sexual harassment scandal forced the Swedish Academy to postpone the 2018 award, for the first time in 70 years.
The Peace Prize will follow on Friday, with bookies predicting a win for Swedish teen climate activist Greta Thunberg on betting sites such as Ladbrokes.
The Economics Prize will wrap up the Nobel prize season on Monday, October 14.
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RCB to play five IPL 2026 home matches in Bengaluru, two in Raipur
Bengaluru (PTI): Defending champions Royal Challengers Bengaluru will play five of their home matches at the M Chinnaswamy Stadium here and the remaining two fixtures at Raipur's Shaheed Veer Narayan Singh International Stadium in the upcoming IPL, the franchise said on Tuesday.
The announcement ended doubts about whether the IPL 2025 winners would be able to play at their home ground, the M. Chinnaswamy Stadium, following the stampede that killed 11 fans after RCB's maiden title win.
Since that tragic indecent, the venue has not hosted any major domestic matches including the Ranji Trophy, Vijay Hazare Trophy or even the Maharaja Trophy KSCA T20.
"This significant development comes after months of hard work and close coordination across all concerned authorities with a common goal of bringing the games back to home ground for the fans," RCB said in a release.
"RCB extends its sincere gratitude to the Government of Karnataka, the Karnataka State Cricket Association and the Karnataka Police for their unwavering guidance, cooperation and support in facilitating the hosting of matches in Bengaluru."
"The collective efforts to ramp up infrastructure and safety measures in time for the IPL season have ensured that the defending champions will play the majority of their home games in their home ground," the franchise added.
The franchise said that the two "home matches" in Raipur will be as "per prior commitment."
RCB CEO Rajesh Menon said the fans deserve to watch their team compete at home.
"The M. Chinnaswamy Stadium is more than just our home ground it is where our identity as a team truly comes alive," he said.
"The energy our fans bring to Bengaluru has always been a driving force for our players, inspiring them through every phase of the game. Our fans have stood by us unconditionally, and they deserve the opportunity to watch their team compete at home."
"After detailed discussions and completing the necessary due process around permissions, we are pleased to confirm that RCB will play five matches in Bengaluru. We sincerely thank the Government of Karnataka, the KSCA, and the Karnataka Police for their support in making this possible," Menon added.
