UK scientists to immunize hundreds with coronavirus vaccine
London: Scientists at Imperial College London say they are immunizing hundreds of people with an experimental coronavirus vaccine in an early trial after seeing no worrying safety problems in a small number vaccinated so far.
Dr Robin Shattock, a professor at the college, told The Associated Press that he and colleagues had just finished a very slow and arduous process of testing the vaccine at a low dose in the initial participants and would now expand the trial to about 300 people, including some over age 75.
"It's well tolerated. There aren't any side effects," he said, adding it was still very early in the study. Shattock, who is leading the vaccine research at Imperial, said he hopes to have enough safety data to start inoculating several thousand people in October.
Since COVID-19 infections have dropped dramatically in Britain, making it difficult to determine whether or not the vaccine works, Shattock said he and his colleagues are also looking to test their vaccine elsewhere.
"We're looking very carefully at the pandemic, at the numbers where the hot spots are and talking to collaborators that have the facilities to do these kinds of studies," he said.
The Imperial vaccine uses synthetic strands of genetic code based on the virus. Once injected into a muscle, the body's own cells are instructed to make copies of a spiky protein on the coronavirus. That should in turn trigger an immune response so the body can fight off any future COVID-19 infection.
Earlier this week, the world's biggest coronavirus vaccine study started in the United States, with the first of 30,000 planned volunteers getting immunized with shots created by the US National Institutes of Health and Moderna Inc.
Several other vaccines made by China and by Britain's Oxford University, based on different vaccine technologies, began smaller final-stage tests in Brazil and other hard-hit countries earlier this month.
The World Health Organization has said multiple vaccine approaches are necessary for COVID-19, noting that the usual success rate for vaccine development is about 10 per cent.
Shattock said there were numerous coronavirus vaccines now in clinical trials, and he predicted that at least some of them would prove to be effective.
"We have 20 vaccines in clinical trials, (so) we can be pretty confident that at least two of those will work," he said. "It really depends on how strong the immune response needs to be to provide protection."
Shattock said he was optimistic the Imperial vaccine would work, but must await the scientific data from the trial.
"I'm just going to hold my breath and wait to see," he said.
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Malian defence minister killed in attack that saw jihadis and rebels seize towns, military bases
Dakar (AP): Malian Minister of Defence Gen. Sadio Camara was killed in an attack as jihadi and rebel forces seized towns and military bases across the country, according to a military officer and two other sources on Sunday.
There was no immediate comment from the Malian government.
“Unfortunately, the Ministry of Defence, Gen. Sadio Camara, has been killed during the attack which targeted his house yesterday,” said a military official who spoke on condition of anonymity because he did not have permission to speak to the media.
Two other people, a civil society leader and a security member, confirmed the information.
Separatist fighters on Saturday joined Islamic militants in launching one of the biggest coordinated attacks on the Malian army in the capital and several other cities that left at least 16 wounded.
The separatists have been fighting for years to create an independent state in northern Mali, while al-Qaida and Islamic State group-aligned militants have been fighting the government for over a decade.
Malian troops and Russian mercenaries withdrew from the northern city of Kidal after the attacks, the rebels said Sunday.
A spokesperson for the Tuareg-led Azawad Liberation Front, or FLA, a separatist group, said the Russian Africa Corps troops and the Malian military withdrew from the city after an agreement was reached for their peaceful exit.
“Kidal is declared free,” said FLA spokesperson Mohamed El Maouloud Ramadan.
The Malian army did not respond to requests for comment but in an earlier statement said they were “tracking down terrorist armed groups in Kidal.”
The separatists have been fighting for years to create an independent state in northern Mali. Kidal had long served as a stronghold of the rebellion before being taken by Malian government forces and Russian mercenaries in 2023. Its capture marked a significant symbolic victory for the junta and its Russian allies.
It was the first time the separatists worked alongside the al-Qaida-linked militant group JNIM, which also claimed responsibility for Saturday's attacks on Bamako's international airport and four other cities, including Kidal, in central and northern Mali.
“This operation is being carried out in partnership with the JNIM, which is also committed to defending the people against the military regime in Bamako,” Ramadan said.
Wassim Nasr, a Sahel specialist and senior research fellow at the Soufan Center security think tank, said that the coordination between the two groups, as well as the explicit call for the Russian military to leave, is new.
“The coordination, conducting attacks all over the country at the same time, real coordination on the military level but also on the political level because both claims of both groups they acknowledged that they worked together, this is a first,” said Nasr.
Mali government spokesperson Gen. Issa Ousmane Coulibaly said on state television late Saturday that 16 people were wounded, including civilians and military personnel, and that several militants were killed. He did not provide a death toll.
The governor of Bamako's district, Abdoulaye Coulibaly, announced a three-day overnight curfew, from 9 p.m. to 6 a.m.
The Economic Community of West African States has condemned the attacks and called on “all states, security forces, regional mechanisms and populations of West Africa to unite and mobilize in a coordinated effort to combat this scourge.”
The separatists called on Russia to “reconsider its support for the military junta in Bamako, whose actions have contributed to the suffering of the civilian population.”
Following military coups, the juntas in Mali, Niger, and Burkina Faso turned from Western allies to Russia for help in combating Islamic militants. But the security situation has worsened in recent times, with a record number of attacks by militants. Government forces have also been accused of killing civilians they suspect of collaborating with militants.
In 2024, an al-Qaida-linked group claimed an attack on Bamako's airport and a military training camp in the capital, killing scores of people.
Ulf Laessing, head of the Sahel program at the Konrad Adenauer Foundation, said that while the attacks were a major blow to the credibility of Mali's Russian partners, JNIM is unlikely to take control of Bamako in the near term due to opposition from the local population.
“The attacks are a major blow to Russia as the mercenaries had no intelligence about the attacks and were unable to protect major cities. They have unnecessarily worsened the conflict by not distinguishing between civilians and combatants,” Laessing said.
