London: A group of leading UK and US scientists, including Indian-origin Cambridge University immunology and infectious disease expert Ravindra Gupta, on Friday called for more investigation to determine the origin of the COVID-19 pandemic, including the theory of an accidental release from a lab in the central Chinese city of Wuhan.

In a letter published in the journal Science', the experts from world leading universities such as Harvard, Stanford and MIT said knowing how COVID-19 emerged is critical for informing global strategies to mitigate the risk of future outbreaks.

They caution that hypotheses about both natural and laboratory spillovers must be taken seriously until there is sufficient data.

Theories of accidental release from a lab and zoonotic spillover both remain viable, they write.

As scientists with relevant expertise, we agree with the WHO director-general, the United States and 13 other countries, and the European Union that greater clarity about the origins of this pandemic is necessary and feasible to achieve. We must take hypotheses about both natural and laboratory spillovers seriously until we have sufficient data, they note.

The zoonotic spillover refers to the virus jumping from bats to humans.

Giving a history of the pandemic, the scientists recall how on December 30, 2019, the Program for Monitoring Emerging Diseases notified the world about a pneumonia of unknown cause in Wuhan, China. This led to identifying the causative agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

In May 2020, the World Health Assembly requested that the World Health Organisation (WHO) director-general work with partners to determine the origins of SARS-CoV-2.

In November 2020, the Terms of Reference for a China-WHO joint study were released. The information, data, and samples for the study's first phase were collected and summarised by the Chinese half of the team; the rest of the team built on this analysis.

Although there were no findings in clear support of either a natural spillover or a lab accident, the team assessed a zoonotic spillover from an intermediate host as likely to very likely', and a laboratory incident as extremely unlikely', they note.

Furthermore, the two theories were not given balanced consideration, they caution.

They point to WHO Director-General Tedros Ghebreyesus' comment that the report's consideration of evidence supporting a laboratory accident was insufficient and offered to provide additional resources to fully evaluate the possibility.

A proper investigation should be transparent, objective, data-driven, inclusive of broad expertise, subject to independent oversight, and responsibly managed to minimise the impact of conflicts of interest. Public health agencies and research laboratories alike need to open their records to the public, the scientists urge.

Finally, in this time of unfortunate anti-Asian sentiment in some countries, we note that at the beginning of the pandemic, it was Chinese doctors, scientists, journalists, and citizens who shared with the world crucial information about the spread of the virus often at great personal cost. We should show the same determination in promoting a dispassionate science-based discourse on this difficult but important issue, they conclude.

The origins of the COVID-19 pandemic remain a widely debated topic, with some scientists and politicians maintaining that the possibility of a lab leak of the deadly virus exists. The Wuhan Institute of Virology (WIV) is near the outbreak's known epicentre of Huanan Seafood Market in Wuhan.

So far, the coronavirus has claimed 3,346,881 lives across the world, along with over 161 million cases, according to Johns Hopkins University.

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New York (AP): Zohran Mamdani became mayor of New York City just after midnight on Thursday, taking the oath of office at a historic, decommissioned subway station in Manhattan.

Mamdani, a Democrat, was sworn in as the first Muslim leader of America's biggest city, placing his hand on a Quran as he took his oath.

“This is truly the honour and the privilege of a lifetime,” Mamdani said.

The ceremony, administered by New York Attorney General Letitia James, a political ally, took place at the old City Hall station, one of the city's original subway stops that is known for its stunning arched ceilings.

He will be sworn in again, in grander style, in a public ceremony at City Hall at 1 pm by US Sen. Bernie Sanders, one of the mayor's political heroes. That will be followed by what the new administration is billing as a public block party on a stretch of Broadway known as the “Canyon of Heroes,” famous for its ticker-tape parades.

Mamdani now begins one of the most unrelenting jobs in American politics as one of the country's most-watched politicians.

In addition to being the city's first Muslim mayor, Mamdani is also its first of South Asian descent and the first to be born in Africa. At 34, Mamdani is also the city's youngest mayor in generations.

In a campaign that helped make “affordability” a buzzword across the political spectrum, the democratic socialist promised to bring transformative change with policies intended to lower the cost of living in one of the world's most expensive cities. His platform included free child care, free buses, a rent freeze for about 1 million households, and a pilot of city-run grocery stores.

But he will also have to face other responsibilities: handling trash and snow and rats, while getting blamed for subway delays and potholes.

Mamdani was born in Kampala, Uganda, the son of filmmaker Mira Nair and Mahmood Mamdani, an academic and author. His family moved to New York City when he was 7, with Mamdani growing up in a post-9/11 city where Muslims didn't always feel welcome. He became an American citizen in 2018.

He worked on political campaigns for Democratic candidates in the city before he sought public office himself, winning a state Assembly seat in 2020 to represent a section of Queens.

Mamdani and his wife, Rama Duwaji, will depart their one-bedroom, rent-stabilised apartment in the outer borough to take up residence in the stately mayoral residence in Manhattan.

Mamdani inherits a city on the upswing, after years of slow recovery from the COVID-19 pandemic. Violent crime has dropped to pre-pandemic lows. Tourists are back. Unemployment, which soared during the pandemic years, is also back to pre-COVID levels.

Yet deep concerns remain about high prices and rising rents in the city.

He'll also have to deal with Republican President Donald Trump.

During the mayoral race, Trump threatened to withhold federal funding from the city if Mamdani won and mused about sending National Guard troops to the city.

But Trump surprised supporters and foes alike by inviting the Democrat to the White House for what ended up being a cordial meeting in November.

“I want him to do a great job and will help him do a great job,” Trump said.

Still, tensions between the two leaders are almost certain to resurface, given their deep policy disagreements, particularly over immigration.

Mamdani also faces scepticism and opposition from some members of the city's Jewish community over his criticisms of Israel's government.

The new mayor and his team have spent the weeks since his election victory preparing for the transition, surrounding Mamdani with seasoned hands who have worked inside or alongside city government.

That included persuading the city's police commissioner, Jessica Tisch, to remain in her position — a move that helped calm fears in the business community that the administration might be planning radical changes in policing strategy.