Washington(AP/PTI): Plunged into a government shutdown, the US is confronting a fresh cycle of uncertainty after President Donald Trump and Congress failed to strike an agreement to keep government programmes and services running by Wednesday's deadline.

Roughly 7,50,000 federal workers are expected to be furloughed, some potentially fired by the Trump administration. Many offices will be shuttered, perhaps permanently, as Trump vows to “do things that are irreversible, that are bad” as retribution.

His deportation agenda is expected to run full speed ahead, while education, environmental and other services sputter. The economic fallout is expected to ripple nationwide.

“We don't want it to shut down,” Trump said at the White House before the midnight deadline.

But the president, who met privately with congressional leadership this week, appeared unable to negotiate any deal between Democrats and Republicans to prevent that outcome.

This is the third time Trump has presided over a federal funding lapse, the first since his return to the White House this year, in a remarkable record that underscores the polarising divide over budget priorities and a political climate that rewards hardline positions rather than more traditional compromises.

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Karachi (PTI): At least 16 people, including many children, were killed and 14 others injured when a suspected gas leakage led to an explosion in a residential building in Pakistan's Karachi on Thursday morning.

“The explosion took place around 4:30 am on the first floor of the building located in the Old Soldier Bazar area when everyone was awake for Sehri time,” police official Jamshed Asher said.

The first day of Ramzan is being observed in Pakistan today.

The police official said that the reason for the explosion apparently was a gas leakage.

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Due to gas shortage in Pakistan’s biggest city, many families especially in lower income residential areas use liquid petroleum gas cylinders at their homes.

Police surgeon Dr Samaiya Syed confirmed that they have received 14 bodies so far from the blast site while 14 injured are under treatment.

The explosion caused a part of the building structure to collapse due to its dilapidated condition.

“We are still searching through the rubble and debris to see if there are any more bodies or survivors,” Chief Fire Officer Humayun Khan said.

The deceased include at least nine children aged between two and 17 while the injured also include seven children.

This is the second major tragedy to occur in Karachi. Last month, a fire broke out in the basement of the Gul Shopping Plaza, a wholesale and retail market, in the Saddar area killing at least 79 people and leaving scores injured.