US recommends 'pause' for Johnson & Johnson vaccine over blood clot reports
Washington, Apr 13: The US is recommending a pause in administration of the single-dose Johnson & Johnson COVID-19 vaccine to investigate reports of potentially dangerous blood clots.
In a joint statement Tuesday, the Centers for Disease Control and Prevention and the Food and Drug Administration said they were investigating clots in six women that occurred in the days after vaccination.
The clots were observed along with reduced platelet counts making the usual treatment for blood clots, the blood thinner heparin, potentially dangerous.
More than 6.8 million doses of the J&J vaccine have been administered in the U.S., the vast majority with no or mild side effects.
U.S. federal distribution channels, including mass vaccination sites, will pause the use of the J&J shot, and states and other providers are expected to follow. The other two authorised vaccines, from Moderna and Pfizer, are not affected by the pause.
CDC's Advisory Committee on Immunization Practices will meet Wednesday to discuss the cases and the FDA has also launched an investigation into the cause of the clots and low platelet counts.
Until that process is complete, we are recommending a pause in the use of this vaccine out of an abundance of caution, Dr. Anne Schuchat, Principal Deputy Director of the CDC and Dr. Peter Marks, director of the FDA's Center for Biologics Evaluation and Research said in a joint statement.
They are recommending that people who were given the J&J vaccine who are experiencing severe headache, abdominal pain, leg pain, or shortness of breath within three weeks after receiving the shot contact their health care provider.
Officials say they also want to educate vaccine providers and health professionals about the unique treatment required for this type of clot.
The J&J vaccine received emergency use authorization from the FDA in late February with great fanfare, with hopes that its single-dose and relatively simple storage requirements would speed vaccinations across the country.
Yet the shot only makes up a small fraction of the doses administered in the U.S. as J&J has been plagued by production delays and manufacturing errors at the Baltimore plant of a contractor.
Last week the drugmaker took over the facility to scale up production in hopes of meeting its commitment to the U.S. government of providing about 100 million doses by the end of May.
Until now concern about the unusual blood clots has centered on the vaccine from AstraZeneca, which has not yet received authorisation in the U.S. Last week, European regulators said they found a possible link between the shots and a very rare type of blood clot that occurs together with low blood platelets, one that seems to occur more in younger people.
The European Medicines Agency stressed that the benefits of receiving the vaccine outweigh the risks for most people. But several countries have imposed limits on who can receive the vaccine; Britain recommended that people under 30 be offered alternatives.
But the J&J and AstraZeneca vaccines are made with the same technology. Leading COVID-19 vaccines train the body to recognize the spike protein that coats the outer surface of the coronavirus. But the J&J and AstraZeneca vaccines use a cold virus, called an adenovirus, to carry the spike gene into the body. J&J uses a human adenovirus to create its vaccine while AstraZeneca uses a chimpanzee version.
The announcement hit US stock markets immediately, with Dow futures falling almost 200 points just over two hours before the opening bell. Shares of Johnson & Johnson dropped almost 3 per cent.
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Osman Hadi murder: Prime accused denies role, claims he was in Dubai
Dubai: The murder case of Bangladeshi student leader Sharif Osman Hadi has taken a new turn after the prime accused, Faisal Karim Masud, publicly denied any involvement in the killing, asserting that he was in Dubai at the time, contradicting earlier claims by Bangladesh police that he had fled to India.
In a video message that has gone viral on social media, the authenticity of which has not been independently verified, Masud rejected the allegations against him and described the case as a fabricated conspiracy. He claimed that a radical political group was responsible for the attack on Hadi and said he had been falsely implicated.
“I am Faisal Karim Masud. I want to state clearly that I am not involved in the murder of Hadi in any way. This case is completely false and based on a fabricated conspiracy,” Masud said in the video. He added that he was forced to leave Bangladesh and travel to Dubai due to the allegations, despite holding a valid five-year multiple-entry visa for the UAE.
Masud acknowledged that he had visited Hadi’s office shortly before the shooting but maintained that their relationship was purely professional. Describing himself as a businessman who owns an IT firm and a former employee of the Ministry of Finance, Masud said he had approached Hadi regarding a job opportunity. According to him, Hadi sought an advance payment of 500,000 taka for arranging the job and also requested donations for various programmes, which he said he provided.
The accused further alleged that his family members were being harassed and falsely implicated in the case. “They have no involvement whatsoever. This kind of inhumane treatment of my family is unjust and unacceptable, and I strongly protest against it,” he said.
Masud also accused Jamaat-linked elements of orchestrating Hadi’s killing, claiming the student leader was targeted by “Jamaati elements” and that he and his younger brother were deliberately framed. A photograph purportedly showing Masud’s UAE visa has also circulated widely online.
Earlier, Bangladesh police had stated that Masud and another accused, Alamgir Sheikh, fled the country after the killing and entered India through the Meghalaya border. Media reports in Bangladesh claimed the two crossed over via the Haluaghat border in Mymensingh district and were currently in India. India, however, has firmly denied any connection between the accused and its territory, calling the allegations a false narrative being pushed by extremist elements.
Sharif Osman Hadi, a key figure in Bangladesh’s student uprising last year, was shot in the head by masked gunmen in Dhaka on December 12 and succumbed to his injuries six days later at a hospital in Singapore. He had emerged as a prominent leader during the student-led protests that culminated in the end of Sheikh Hasina’s rule.
