Bharat Biotech begins clinical trials of TB vaccine on adults in India
Hyderabad (PTI): Bharat Biotech International Ltd on Sunday said it started clinical trials of the Tuberculosis vaccine Mtbvac on adults in India. This is the first vaccine against Tuberculosis derived from a human source by the Spanish biopharmaceutical company, Biofabri, a press release from Bharat Biotech said.
The release said that Mtbvac is being developed for two purposes; firstly, as a more effective and potentially longer-lasting vaccine than BCG ( Bacillus Calmette Gu rin) for newborns and secondly, for the prevention of TB in adults and adolescents, for whom there is currently no effective vaccine.
The trials are carried out by Bharat Biotech in close collaboration with Biofabri.
Trials to evaluate the safety and immunogenicity of Mtbvac have started with a pivotal safety, immunogenicity and efficacy trial which has been planned to start in 2025, the release said.
It is a giant step to test in adults and adolescents in the country where 28 per cent of the world's TB cases accumulate. TB remains one of the world's leading infectious causes of death, especially in India, Esteban Rodriguez, CEO of Biofabri said.
Krishna Ella, Executive Chairman Bharat Biotech said "Our quest for a more effective vaccine against Tuberculosis received a big boost today, with clinical trials in India.
Our goal to develop TB vaccines to prevent disease in adults and adolescents has taken a big step today."
The Mtbvac vaccine has passed several milestones before entering clinical trials in India. After the recent completion of a Phase-2 dose finding trial, a double-blind controlled Phase-3 clinical trial in newborns has been started in 2023 to compare the vaccine with the current BCG vaccine.
As many as 7,000 newborns from South Africa, 60 from Madagascar and 60 from Senegal will be vaccinated. To date, more than 1,900 babies have been vaccinated, the release added.
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Strictest action promised after students forced to remove sacred thread at Bengaluru CET exam centre
Bengaluru (PTI): Bengaluru Urban Deputy Commissioner Jagadeesha G on Monday said the government has decided to take the “strictest possible action” against those responsible for allegedly forcing some students to remove their ‘janivara’ (sacred thread) before entering the venue of the CET exam last week.
He said a committee of senior officials constituted to inquire into the incident reported that, prima facie, it appears the students were “intentionally” made to remove the ‘janivara’.
The city police have already booked three staff members of a private college in Bengaluru for allegedly forcing some students to remove their ‘janivara’ before entering the venue of the Common Entrance Test (CET-2026) last week.
Similar incidents last year in Shivamogga and Bidar had triggered controversy, following which the Karnataka Examinations Authority (KEA) issued clear directions not to force students to remove any religious identification or symbol during exams.
“Despite KEA taking measures such as appointing dress code officials and providing training on dos and don’ts to prevent such incidents from recurring after last year’s cases, there has been a dereliction of duty this time,” Jagadeesha told reporters here.
“To take strict action against those responsible, an FIR has been registered, and arrests have been made. An inquiry has been conducted by senior officials, and those responsible have been suspended,” he added.
Stating that the inquiry report has been submitted at the district level, he said it will be forwarded to the government.
Based on the findings, it has also been decided that KEA will not conduct CET exams at the institution where the incident occurred, he added.
“The strictest possible action is being taken by the district administration and the government,” he added.
The deputy commissioner had constituted a committee headed by the additional deputy commissioner to investigate the incident and submit a report within two days.
“Exams have been held at several centres across the state, and nowhere else has this issue occurred. If students were forced to remove ‘janivara’ at this centre, it appears that it was intentional. We have taken it seriously,” he said, adding that strict action has been recommended to ensure such incidents do not recur.
Noting that senior officials were appointed for the inquiry, the DC said that after a thorough investigation and verification—which included statements from students, the school principal, exam observers, CCTV footage, and documents—it prima facie appears that students were intentionally made to remove the ‘janivara’.
“We are recommending strict action. The government has also ordered a detailed police investigation, and an FIR has been registered in connection with the incident,” he added.
