New Delhi (PTI): In the wake of Karnataka Chief Minister Siddaramaiah linking heart-related deaths in Hassan district to Covid vaccine, the Union Health Ministry on Wednesday said extensive studies by ICMR and AIIMS have conclusively established no linkages between coronavirus vaccines and sudden deaths.

Siddaramaiah had on Tuesday said "hasty approval and distribution" of the Covid vaccine to the public could also be a reason for these deaths.

He urged everyone to visit the nearest health centre immediately for a check-up if they have symptoms such as chest pain or difficulty breathing, and not to ignore these signs.

The ministry said the matter of sudden unexplained deaths has been investigated through several agencies in the country and these studies have conclusively established that there is no direct link between COVID-19 vaccination and reports of sudden deaths.

Studies by the Indian Council of Medical Research (ICMR) and National Centre for Disease Control (NCDC) affirm that COVID-19 vaccines in India are safe and effective, with extremely rare instances of serious side effects, it said.

Sudden cardiac deaths can result from a wide range of factors, including genetics, lifestyle, pre-existing conditions, and post-Covid complications, the ministry said in a statement.

The ICMR and NCDC have been working together to understand the causes behind sudden unexplained deaths, especially in young adults between the ages of 18 and 45 years.

To explore this, two complementary studies were undertaken using different research approaches -- one based on past data and another involving real-time investigation.

The first study conducted by ICMR's National Institute of Epidemiology (NIE) was titled "Factors associated with unexplained sudden deaths among adults aged 18-45 years in India - a multi-centric matched case control study."

This study was carried out from May to August 2023 across 47 tertiary care hospitals in 19 states and Union territories, the statement said.

It looked at individuals who appeared to be healthy but died suddenly between October 2021 and March 2023.

The findings have conclusively showed that COVID-19 vaccination does not increase the risk of unexplained sudden deaths in young adults.

The second study titled "Establishing the cause in sudden unexplained deaths in young" is currently being conducted by the All India Institute of Medical Sciences (AIIMS), New Delhi with funding and in collaboration with ICMR.

This is a prospective study aimed at determining the common causes of sudden deaths in young adults. Early analysis of data from the study indicates that heart attacks or myocardial infarction (MI) continue to be the leading cause of sudden death in this age group, the statement said.

Importantly, no major changes in the pattern of causes have been observed when compared with previous years. In majority of the unexplained death cases, genetic mutations have been identified as a possible cause of these deaths. The final results will be shared once the study is complete.

Together, these two studies offer a more comprehensive understanding of sudden unexplained deaths in young adults in India.

It has also been found that COVID-19 vaccination does not appear to increase the risk, whereas, the role of underlying health issues, genetic predisposition and risky lifestyle choices does play a role in unexplained sudden deaths, the statement said.

"Scientific experts have reiterated that statements linking Covid vaccination to sudden deaths are false and misleading, and are not supported by scientific consensus," the statement said.

Speculative claims without conclusive evidence risk undermining public confidence in vaccines, which have played a crucial role in saving millions of lives during the pandemic, it said.

Such unfounded reports and claims could strongly contribute to vaccine hesitancy in the country, thereby adversely impacting public health.

The government remains committed to evidence-based public health research to protect the well-being of its citizens, the statement said.

The Karnataka chief minister had said more than 20 people have died due to heart attacks in the past month alone in just one district of Hassan.

"The government is taking this matter very seriously. To identify the exact cause of these series of deaths and to find solutions, a committee of experts has been formed under the leadership of Dr Ravindranath, Director of Jayadeva Institute of Cardiovascular Sciences and Research, and they have been instructed to submit a study report within 10 days," he said in a post on X.

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Dubai (AP): The United States is warning shipping companies that they could face sanctions for making payments to Iran to safely pass through the Strait of Hormuz.

The alert posted Friday by the US Office of Foreign Assets Control adds another layer of pressure in the standoff between the US and Iran over control of the Strait of Hormuz.

About a fifth of the world's trade in oil and natural gas typically passes through the strait at the mouth of the Persian Gulf in peacetime.

Iran effectively closed the strait to normal traffic by attacking and threatening to attack ships after the US and Israel launched a war on Feb. 28. It later began offering some ships safe passage by detouring them through alternate routes closer to its shoreline, charging fees at times for the service.

That "tollbooth” effort is the focus of the US sanctions warning.

The payment demands could include transfers not only in cash but also “digital assets, offsets, informal swaps, or other in-kind payments,” including chartibale donations and payments at Iranian embassies, OFAC said.

“OFAC is issuing this alert to warn US and non-US persons about the sanctions risks of making these payments to, or soliciting guarantees from, the Iranian regime for safe passage. These risks exist regardless of payment method,” it said.

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The US responded to Iran's closure of the strait with a naval blockade of its own on April 13, preventing any Iranian tankers from leaving and depriving Iran of oil revenue it needs to shore up its ailing economy.

The US Central Command said 45 commercial ships have been told to turn around since the blockade began.

Trump rejects Iranian proposal

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The warning came as US President Donald Trump swiftly rejected Iran's latest proposal to end the war between the countries.

“They want to make a deal, I'm not satisfied with it, so we'll see what happens,” Trump said Friday at the White House. He didn't elaborate on what he saw as its shortcomings but expressed frustration with the Iranian leadership.

“It's a very disjointed leadership,” Trump said. “They all want to make a deal, but they're all messed up.”

Iran's state-run IRNA news agency reported Iran handed over its plan to mediators in Pakistan on Thursday night.

The shaky three-week ceasefire between the US and Iran appears to be holding, though both countries have traded accusations of violations. The standoff is increasingly putting pressure on the global economy, driving up prices and leading to shortages of fuel and other products tied to the oil industry.

Negotiations continued by phone after Trump called off his envoys' trip to Pakistan last week, the president said. Trump this week floated a new plan to reopen the critical passageway used by America's Gulf allies to export their oil and gas.

Iranian Foreign Minister Abbas Araghchi has briefed many of his regional counterparts on the country's initiatives to end the ear, according to his social media. He also held talks Friday with European Union foreign policy chief Kaja Kallas, who is in contact with the EU's Gulf partners.

China's UN envoy urges Iran to lift restrictions

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Fu Cong, the Chinese ambassdor to the United Nations, said Friday that maintaining the ceasefire is “the most urgent issue" as well as bringing together the sides to resume good faith negotiations “to make sure that the ground is laid for reopening of Hormuz.”

Foreign Minister Wang Yi “has been on the phone almost constantly” with representatives from all sides, Fu said, adding that China supports Pakistan's efforts to mediate between the parties.

Fu stressed the root cause of the tremendous suffering in Iran and neighboring countries and the growing turmoil in the global economy, especially in developing countries, “is the illegitimate war by the US and Israel.