New Delhi, Nov 8: Drug firm Zydus Cadila on Monday said it has received an order to supply one crore doses of its COVID-19 vaccine, ZyCoV-D, to the Indian government at Rs 265 per dose.

"Zydus Cadila has received an order to supply one crore doses of ZyCoV-D, the world's first Plasmid DNA Vaccine, to the Government of India at Rs 265 per dose and the needle-free applicator being offered at Rs 93 per dose, excluding GST," the pharma firm said in a regulatory filing.

The pricing has been decided in consultation with the central government, it added.

The vaccine will be administered using a needle-free applicator as opposed to traditional syringes. The applicator, called "PharmaJet".

The PharmaJet is a needle free applicator to ensure painless intradermal vaccine delivery which also leads to a significant reduction in any kind of major side effects.

"We are happy to support the government's vaccination programme with ZyCoV-D. The needle-free application of the vaccination, we hope, will motivate many more to vaccinate and safeguard themselves from COVID-19, especially children and young adults in the age group of 12 to 18 years," Zydus Cadila MD Sharvil Patel said.

ZyCoV-D is the first DNA plasmid vaccine in the world for human use, developed indigenously by the company against the COVID-19 virus, Zydus Cadila said.

The vaccine has shown good stability at temperatures of around 25 degrees for at least three months. The thermostability of the vaccine will help in easy transportation and storage of the vaccine without any problems of fluctuations in temperature, it added.

ZyCoV-D is the first vaccine cleared by India's drug regulator for inoculation of those aged 12 years and above.

The three doses of ZyCoV-D, are to be administered 28 days apart. The vaccine was given emergency use authorization (EUA) by the Indian drug regulator on August 20, this year.

The company has also sought approval for the two dose regimen of the vaccine.

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Barcelona (AP): Real Madrid slapped players Federico Valverde and Aurélien Tchouaméni with half-a-million-euro ($588,000) fines on Friday for their altercation during practice.

The massive fines came a day after the midfielders tussled when the team trained. Valverde said in a post on social media on Thursday that no punches were thrown. But Valverde knocked his head on a table and he suffered a small cut that required a brief hospital visit.

On social media, Valverde initially called it a “meaningless fight” with a teammate and said “everything has been blown out of proportion."

His employers, however, considered it a significant enough breach of team discipline to nail both Valverde and Tchouaméni with fines that bite even the bank account of a top soccer player. The half-a-million euro penalties reflect the reputational damage the club was enduring in a chaotic end to a disappointing season.

In a statement, the 15-time European champion said its disciplinary action was concluded after both players expressed to the club “their complete remorse for what happened and apologized to one another.”

Madrid added they also apologized to their teammates, the coaching staff and club supporters, as well as showing their willingness to accept whatever disciplinary action the club deemed “opportune.”

Tchouaméni was back training with Madrid on Friday, two days before they play at Barcelona in a clasico. Madrid has to win otherwise Barcelona will be crowned La Liga champion.

After being notified of the fine, he posted a public apology to the club and its fans on social media.

“What happened this week in training is unacceptable,” Tchouaméni wrote. "I say this while thinking about the example we are expected to set for young people, whether in football or at school.

“Above all, I am sorry for the image we projected of the club.”

Valverde was not at practice due to the head knock.

Both players are set to play in the World Cup next month, with Tchouaméni playing for France and Valverde for Uruguay. 

Chaotic end to a poor season

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The run-in between the players, who for seasons have played side by side in Madrid's midfield, came after they argued this week in previous training sessions. But tempers boiled over on Thursday. Spanish media was rife with reports that the players previously disagreed over the club's decision to let coach Xabi Alonso go after just months on the job.

It was not the only altercation involving Madrid players during training this week. Álvaro Carreras confirmed he was in a “minor” incident with a teammate. Spanish media said he and fellow defender Antonio Rüdiger got into a scuffle.

Álvaro Arbeloa, the coach who was promoted from Madrid's reserve team when Alonso was fired in January, will face tough questions on what went wrong inside the changing room when he gives a press conference on Saturday ahead of the clasico at Camp Nou.

Madrid is facing a second consecutive campaign without a major trophy amid rumors in the Spanish media that club president Florentino Pérez is considering bringing back Jose Mourinho to straighten out his underperforming team.