London (PTI): Exposure to traffic related air pollution is associated with an increased risk of multiple long-term physical and mental health conditions, according to a study.

This is the largest study worldwide -- conducted on over 364,000 (over 3.6 lakh) people in England -- to examine whether air pollution exposure is linked with the occurrence of multiple long-term health conditions, the researchers said.

The study, published in the journal Frontiers in Public Health, showed that high levels of traffic-related air pollution - fine particulate matter (PM2.5) and nitrogen dioxide (NO2) were associated with an increased risk of having at least two long term health conditions.

The strongest associations were observed for co-occurring neurological, respiratory, cardiovascular and common mental health conditions such as depression and anxiety, the researchers said.

"People with more than one long-term health condition have a lower quality of life and greater dependence on the healthcare system," said Amy Ronaldson, Research Associate at King's College London and first author on the study.

"Our research has indicated that those people that live in areas of higher traffic-related air pollution are at greater risk of having multiple health conditions," Ronaldson said.

However, the study does not prove that air pollution causes multimorbidity, but it does warrant further research in this area, the researchers said.

They analysed data from UK Biobank - a large-scale biomedical database and research resource containing anonymised genetic, lifestyle and health information from half a million UK participants aged between 40 and 69 years.

Participants were assessed for 36 physical and five mental health chronic conditions. Multimorbidity was defined as having two or more of these conditions.

Physical and mental health data from UK Biobank in 2010 were linked with the estimated concentration of air pollution at the residential address of the participants.

The study found that those participants exposed to higher concentrations above 10 microgramme per cubic metre ( g/m3) of fine particulate matter had a 21 per cent increased risk of two or more co-occurring conditions compared to those exposed to concentrations below 10 g/m3.

For participants exposed to above 30 g/m3 of NO2, the study showed a 20 per cent increased risk of having two or more co-occurring conditions compared to those participants that were exposed to concentrations of NO2 below 20 g/m3.

Amongst those with multiple conditions, increased exposure to both PM2.5 and NO2 was linked to a greater severity of the co-occurring conditions, the researchers said.

"How air pollution affects multiple organs and systems at the same time is not yet fully understood, but there is some evidence that mechanisms such as inflammation, oxidative stress and immune activation could be triggered by air particulates, which can cause damage to the brain, heart, blood, lungs and gut," said Ioannis Bakolis from King's College London.

"Our study suggests that it could be through shared mechanisms that air pollution negatively impacts several body systems and increases the likelihood of people developing multiple long term health conditions," said Bakolis, senior author on the study.

Researchers identified several patterns in the associations. The strongest links were primarily between conditions relating to the respiratory system such as asthma and chronic obstructive pulmonary disease as well as the cardiovascular system like atrial fibrillation, coronary heart disease, and heart failure.

The link was also seen with neurological and common mental conditions such as stroke, substance abuse, depression and anxiety, the researchers added.

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Bengaluru (PTI): Targeting Chief Minister Siddaramaiah and the Congress government in Karnataka on corruption, BJP leader R Ashoka on Friday said, being foolish was forgivable, but being "shameless" in public life was not.

The Leader of Opposition in the state Assembly claimed that in just 30 months of its tenure, the Congress administration has broken every previous record on corruption-related controversies.

He was responding to Siddaramaiah's post on 'X' on Thursday hitting back at the BJP, stating that Upa Lokayukta Justice Veerappa's claims of "63 per cent corruption" were based on his report in November 2019, when BJP's B S Yediyurappa was the CM.

"But Ashoka, without understanding the Upa Lokayukta's statement properly, has ended up tying the BJP's own bells of sins onto our heads and has effectively shot himself in the foot," the CM had said, as he accused Ashoka of foolishness for trying to twist Veerappa's statement to target the current government.

Responding, Ashoka said, "it is one thing to be called foolish in politics, that can be forgiven."

"But in public life, especially in the Chief Minister's chair, one must never become shameless," Ashoka posted on 'X' on Friday addressing Siddaramaiah.

Noting that the CM himself had admitted on the floor of the Assembly that a Rs 87 crore scam took place in the Valmiki Development Corporation, he said that when a CM acknowledges such a massive irregularity inside the floor of the House, the natural expectation is immediate action and accountability.

"But instead of taking responsibility, you continue in office as if nothing has happened. What should the people of Karnataka call this, if not sheer shamelessness," he asked.

Pointing out that the CM's Economic Advisor and senior Congress MLA Basavaraja Rayareddy had publicly stated that under Congress rule, Karnataka has become No.1 in corruption, Ashoka said, "Yet, you still cling to the Chief Minister's chair without a moment of introspection. What should the people of Karnataka call this, if not sheer shamelessness."

Senior Congress MLA C R Patil had exposed the "money for House" racket in the Housing Department and even warned that the government would collapse if the details he has were made public, Ashoka said.

"Despite such serious allegations from within your own party (Congress), you neither initiated an inquiry nor acted against the concerned minister. What should the people of Karnataka call this, if not sheer shamelessness," Ashoka asked the CM.

Highlighting the "40 percent commission" allegation Congress made against the previous BJP government, the opposition leader said, the commission that the Siddaramaiah government appointed concluded that the accusation was baseless.

"After your own panel demolished your own claim, what moral right do you have to continue repeating that allegation. What should the people of Karnataka call this, if not sheer shamelessness," he asked.

For the last two and a half years, Karnataka has been 'drowning' in corruption, scandals, irregularities and allegations across departments. Ashoka said, "If I begin listing every case that emerged under your government, even 24 hours would not be enough." 

"And the most tragic aspect of your administration is this: the unbearable pressure, corruption demands and administrative harassment under your government pushed several officers and contractors into extreme distress - including the suicide of Chandrasekharan which exposed the Valmiki Development Corporation scam - a sign of how deeply broken the system has become under your watch," he said.

Instead of fixing this hopeless environment, the government has tried to bury every complaint and silence every voice, he charged.

"Being foolish is forgivable, but being shameless in public life is definitely not."

"When your own ministers admit scams, when your own advisors certify Karnataka as No.1 in corruption, and when your own MLAs expose rackets inside your departments - clinging to power without accountability is not leadership. It is shamelessness in its purest form." PTI KSU

Earlier on Thursday Ashoka had demanded that the corruption case and allegations in the state against the Congress government be handed over to a CBI investigation, citing a reported statement by Upalokaykta Justice Veerappa alleging "63 per cent corruption", following which Siddaramaiah hit back at the BJP leader.