New York: Inflammation, driven by obesity, may reduce the number of taste buds on the tongue by 25 per cent, while affecting a person's sensitivity to the taste of food, researchers have found.
Obesity is known to be associated with a chronic state of low-grade inflammation in the adipose tissue that stores energy in the form of fat.
The adipose tissue further produces pro-inflammatory cytokines -- molecules that serve as signals between cells -- including one called TNF-alpha.
Researchers noted that a high-fat diet increases the level of TNF-alpha surrounding the taste buds, making them less sensitive to the taste of food.
"Our findings suggest that gross adiposity stemming from chronic exposure to a high-fat diet is associated with a low-grade inflammatory response causing a disruption in the balancing mechanisms of taste bud maintenance and renewal," said Robin Dando, Assistant Professor at the Cornell University in the US.
A taste bud comprises of approximately 50 to 100 cells of three major types, each with different roles in sensing the five primary tastes (salt, sweet, bitter, sour, and umami). Taste bud cells turn over quickly, with an average lifespan of just 10 days.
The turnover of taste bud cells normally arises from a balanced combination of programmed cell death (a process known as apoptosis) and generation of new cells from special progenitor cells.
The study, published in the journal PLOS Biology, observed that the rate of apoptosis increased in obese mice, whereas the number of taste bud progenitor cells in the tongue declined, likely explaining the net decline in the number of taste buds.
Let the Truth be known. If you read VB and like VB, please be a VB Supporter and Help us deliver the Truth to one and all.
Jakarta, Apr 17: Indonesian authorities issued a tsunami alert Wednesday after eruptions at Ruang mountain sent ash thousands of feet high. Officials ordered more than 11,000 people to leave the area.
The volcano on the northern side of Sulawesi island had at least five large eruptions in the past 24 hours, Indonesia's Centre for Volcanology and Geological Disaster Mitigation said. Authorities raised their volcano alert to its highest level.
At least 800 residents left the area earlier Wednesday.
Indonesia, an archipelago of 270 million people, has 120 active volcanoes. It is prone to volcanic activity because it sits along the “Ring of Fire,” a horseshoe-shaped series of seismic fault lines around the Pacific Ocean.
Authorities urged tourists and others to stay at least 6 km (3.7 miles) from the 725-metre (2,378 foot) Ruang volcano.
Officials worry that part of the volcano could collapse into the sea and cause a tsunami as in a 1871 eruption there.
Tagulandang island to the volcano's northeast is again at risk, and its residents are among those being told to evacuate.
Indonesia's National Disaster Mitigation Agency said residents will be relocated to Manado, the nearest city, on Sulawesi island, a journey of six hours by boat.
In 2018, the eruption of Indonesia's Anak Krakatau volcano caused a tsunami along the coasts of Sumatra and Java after parts of the mountain fell into the ocean, killing 430 people.