10 new cancer risk genes identified
London, July 12 : Using publicly available data, researchers have identified 10 new genes that are predisposed to ovarian and breast cancer among others, an advance that would contribute to improving cancer diagnoses and prevention in the future.
There are many genetic causes of cancer. While some mutations are inherited from parents, others are acquired all throughout life due to external factors or due to mistakes in copying DNA.
In the study, published in Nature Communications, a team of researchers developed a new statistical method named ALFRED and identified 13 candidate cancer predisposition genes, of which 10 are new from tumour sequencing data.
"We applied our method to the genome sequences of more than 10,000 cancer patients with 30 different tumour types and identified known and new possible cancer predisposition genes that have the potential to contribute substantially to cancer risk," said principal investigator Ben Lehner, ICREA -- Catalan Institution for Research and Advanced Studies in Spain.
"Our computational method uses an old idea that cancer genes often require 'two hits' before they cause cancer. We developed a method that allows us to systematically identify these genes from existing cancer genome datasets," said Solip Park, from the Centre for Genomic Regulation (CRG) -- a Barcelona-based research facility.
The method allows researchers to find risk variants without a control sample, meaning they do not need to compare cancer patients to groups of healthy people.
"Our results show that the new cancer predisposition genes may have an important role in many types of cancer. For example, they were associated with 14 per cent of ovarian tumours, seven per cent of breast tumours and to about one in 50 of all cancers," Park said.
Inherited variants in one of the newly-proposed risk genes -- NSD1 -- may also be implicated in at least three out of 1,000 cancer patients, the researchers explained.
For the study, the team combined data from many different projects and by applying a new computational method, were able to identify important cancer genes that were not identified by the original studies.
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Regulator DGCA eases flight duty norms for pilots amid IndiGo crisis
Mumbai (PTI): Aviation watchdog DGCA on Friday eased the flight duty norms by allowing substitution of leaves with a weekly rest period amid massive operational disruptions at IndiGo, according to sources.
As per the revised Flight Duty Time Limitations (FDTL) norms, "no leave shall be substituted for weekly rest", which means that weekly rest period and leaves are to be treated separately. The clause was part of efforts to address fatigue issues among the pilots.
Citing IndiGo flight disruptions, sources told PTI that the Directorate General of Civil Aviation (DGCA) has decided to withdraw the provision 'no leave shall be substituted for weekly rest' from the FDTL norms.
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"In view of the ongoing operational disruptions and representations received from various airlines regarding the need to ensure continuity and stability of operations, it has been considered necessary to review the said provision," DGCA said in a communication dated December 5.
The gaps in planning ahead of the implementation of the revised FDTL, the second phase of which came into force from November 1, have resulted in crew shortage at IndiGo and is one of the key reasons for the current disruptions.
#BREAKING: #DGCA relaxes a clause which debarred airlines to club leaves with weekly rest to mitigate #IndiGo crisis
— Economic Times (@EconomicTimes) December 5, 2025
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