New York, April 22: Researchers have found that activity in decision-making brain regions of people who use recreational stimulants can predict who will discontinue their use and who will develop a drug use disorder.
The findings of the study, led by Martin Paulus of Laureate Institute of Brain Research in Oklahoma, suggested that an inability to learn from previous risky decisions in some people may predispose them to continue drug use despite the negative consequences.
"Our sample of recreational users offers a unique approach to studying addiction," said first author Melanie Blair, a doctoral student in the laboratory of Jennifer Stewart of City University of New York.
"By finding differences between our groups prior to problematic use, our results suggest that certain brain patterns might be existing vulnerabilities that predispose an individual to addiction," Blair added.
For the study, published in the journal Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, researchers used brain imaging to measure the activity of several brain regions involved in decision making in 144 young adults.
The study measured brain activity in young adults using recreational stimulants, including cocaine and the prescription amphetamines Adderall and Ritalin, and followed up three years later to determine the participants' outcome.
During the brain scans, the participants performed a task requiring them to make risky or safe decisions. Although all participants in the study were experimenting with stimulants at the time, some showed a tendency for making riskier choices.
"Compared to individuals who stopped using, those who later developed problem use were more reactive to rewards and showed weaker activity in regions of the brain that are critical for decision making," Blair said.
These participants had lower activity in a brain circuit that provides feedback on risky decisions, suggesting they might not be as good at adapting their behaviour-based on previous experiences, the researcher added.
Weaker brain activity in regions associated with decision making also predicted greater marijuana use in the future, they noted.
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Karnataka govt tables Rs 14,767 cr supplementary estimates in assembly
Bengaluru (PTI): The Karnataka government on Monday tabled the supplementary estimates in the assembly, totalling Rs 14,767 crore of additional expenditure for the current fiscal.
Tabled by Revenue Minister Krishna Byre Gowda on behalf of Chief Minister Siddaramaiah, supplementary estimates are additional expenditures incurred by the government over and above the budget provisions.
In the fiscal ending March, additional expenditures include Rs 147 crore on the Sadhana Samavesha to mark two years of the Congress government and Rs 223 crore for railway barricading to prevent human-elephant conflict.
As per the supplementary estimates, the government spent Rs 1.25 crore to purchase a Volvo XC90 for former Prime Minister H D Deve Gowda.
It also includes -- Rs 1,025 crore to clear various irrigation works bills, Rs 15 crore for helicopter and air travels by Governor, CM, ministers and other VIPs, Rs 110 crore towards scholarship and tuition fee reimbursement for minority students, Rs 15 crore for development of various temples, maths and trusts.
The government also spent Rs 1.4 crore to print a book comprising 'selected' speeches of Governor Thaawarchand Gehlot, Rs 50 lakh to clear pending electricity and water bills of ministers' residences, Rs 10 crore towards rehabilitation of families affected by landslides at Meppadi in Wayanad, Kerala.
Rs 5 crore each for Brahmin Development Board and Arya-Vysya Development Corporation, Rs 60 lakh to Supreme Court senior advocate Kapil Sibal for two appearances representing the government, Rs 5.13 crore towards bills from the Belagavi winter session of the legislature, Rs 5.5 crore towards pending bills from the 2019 and 2021 Assembly bypolls and the upcoming Davangere South and Bagalkot bypolls, are among the expenditures incurred.
