Decoded: Which brain region helps us stay conscious?
New York, June 22: Scientists, including one of Indian-origin, have found that a brain region -- associated with cognitive behaviours, decision making, and moderating social behaviour -- determines our overall level of consciousness.
The study, conducted on rats, provided evidence that the prefrontal cortex has a switchboard-like relationship with other areas of the brain, helping to ignite awareness of visual information.
"The study suggests that the prefrontal cortex has the potential to play a role in coordinating the level of consciousness," said George Mashour from the University of Michigan.
The results could also be explored for applications in people with disorders of consciousness, such as coma or vegetative states.
"It's very difficult and dangerous to directly intervene at the level of arousal centres in the brainstem because of its location, small size, and nearby vital functions.
"Maybe the prefrontal cortex is an accessible gateway to some of those other arousal systems that could be leveraged in a clinical setting outside of anesthesia," he said.
In the study, published in the journal Current Biology, the team gave anesthetised rats with a common anesthetic used in humans and exposed their prefrontal and parietal lobe -- a brain region associated with processing sensory information and interpreting visual information -- to drugs that ramped up the effect of neurotransmitters and measured their brain activity and behaviour.
To see what had the causal power to take an unconscious brain receiving ongoing anesthesia and wake it up, the team targeted two neurotransmitters that are associated with wakefulness: acetylcholine and norepinephrine, said Dinesh Pal, from the varsity.
The findings showed that when exposed to an acetylcholine-receptor activator, the rats' brain waves -- normally slow during sleep and anesthesia -- sped up.
But rats were able to start behaving as though they were awake only with prefrontal cortex stimulation, all while continuing to receive the same level of anesthesia that is used clinically for surgery in humans.
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'Even Ajmal Kasab was given a fair trial': SC remarks in Yasin Malik case
New Delhi, Nov 21: Even Ajmal Kasab was given a fair trial in our country, the Supreme Court on Thursday remarked and indicated it may set up a courtroom inside Tihar Jail for the trial of J&K separatist leader Yasin Malik in a kidnapping case.
A bench of Justices Abhay S Oka and Augustine George Masih was hearing a CBI plea against the September 20, 2022 order of a Jammu trial court that directed Malik, serving life term in Tihar jail, to be produced before it physically to cross-examine the prosecution witnesses in the kidnapping case of Rubaiya Sayeed, daughter of politician Mufti Mohammad Sayeed.
The bench, however, remarked, "How will cross-examination be done online? There is hardly any connectivity in Jammu... In our country, a fair trial was given even to Ajmal Kasab and legal assistance was given to him in the high court."
Kasab, the lone Pakistani gunman caught alive after the Mumbai terror attack, was hanged till death at the Yerawada Central Prison .
The bench told Solicitor General Tushar Mehta, representing the CBI, to take instructions on the total number of witnesses in the case.
Mehta pointed out security concerns and said Malik couldn't be taken to Jammu for the trial.
The law officer accused Malik of "playing tricks" for having asked to appear personally and not engaging a lawyer. Mehta said Malik was not an ordinary criminal and showed a purported photograph of Malik sharing the dais with terrorist Hafiz Saeed.
The top court said it could order trial to take place inside the jail premises and ask the judge to come to the national capital for the proceedings.
The bench, however, noted all the accused persons in the matter had to be heard before it passes an order.
Mehta said Malik appearing in the Supreme Court physically raised security concerns previously.
The bench said Malik could be allowed to appear virtually in the apex court proceedings and posted the matter on November 28.
The CBI in the meantime was directed to amend its petition and implead all accused persons as respondents.
In 2023, Mehta wrote to then Union Home Secretary Ajay Kumar Bhalla flagging a "serious security lapse" after Malik was brought to the Supreme Court to appear in a case.
Malik, serving life sentence in a terror-funding case, was brought to the high-security apex court premises in a prison van escorted by armed security personnel without the court's permission.
Expressing surprise at his presence, Mehta informed the apex court there was a procedure for high-risk convicts to be allowed into the courtroom to argue their case personally.
The CBI said Malik, the top leader of the Jammu and Kashmir Liberation Front (JKLF), was a threat to national security and cannot be allowed to be taken outside the Tihar jail premises.
The apex court on April 24, 2023, issued notices on the CBI's appeal following which the incarcerated JKLF chief wrote a letter to the registrar of the Supreme Court on May 26, 2023 seeking permission to appear in person to plead his case.
An assistant registrar took up his request on July 18, 2023 and said the apex court would pass necessary orders -- a decision the Tihar Jail authorities reportedly misconstrued to allow Malik to appear and argue his case.
Mehta referred to the CBI's contention in its appeal against the trial court order to bring Malik to Jammu for the in-person examination of the witnesses in the kidnapping case, and said under Section 268 of the CrPC a state government may direct certain people to not be shifted from the confines of a prison.
On September 20, 2022, a special TADA court in Jammu directed Malik to be physically produced before it on the next hearing for him to cross-examine prosecution witnesses in the kidnapping case.
The CBI challenged the trial court order before the Supreme Court as appeals in TADA cases are only heard by the top court.
Rubaiya was abducted near Lal Ded Hospital in Srinagar on December 8, 1989 and freed five days later after the then BJP-backed V P Singh government at the Centre released five terrorists in exchange.
Mufti, who now lives in Tamil Nadu, is a prosecution witness of the CBI, which took over the case in early 1990s.
Malik is lodged in Tihar jail after he was sentenced by a special NIA court in May, 2023 in a terror-funding case.
